A Study of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection

PHASE2CompletedINTERVENTIONAL
Enrollment

471

Participants

Timeline

Start Date

August 1, 2019

Primary Completion Date

March 29, 2021

Study Completion Date

April 26, 2022

Conditions
Hepatitis B, Chronic
Interventions
DRUG

JNJ-73763989

JNJ-73763989 will be administered as medium dose (Arms 1 and 3), high dose (Arm 2), and low dose (Arm 4) as subcutaneous injection.

DRUG

Placebo for JNJ-73763989

Placebo for JNJ-73763989 will be administered as subcutaneous injection.

DRUG

JNJ-56136379

JNJ-56136379 tablets will be administered orally.

DRUG

Placebo for JNJ-56136379

Placebo for JNJ-56136379 tablets will be administered orally.

DRUG

Nucleos(t)ide Analog (NA)

NA treatment that is either of ETV, TDF or TAF tablets will be administered orally.

Trial Locations (108)

1200

Cliniques Universitaires Saint Luc, Brussels

2650

UZ Antwerpen, Edegem

UZA-SGS, Edegem

3000

UZ Leuven, Leuven

6800

Ankara Bilkent Sehir Hastanesi, Ankara

8035

Hosp Univ Vall D Hebron, Barcelona

9000

Universitair Ziekenhuis Gent, Ghent

10016

NYU Hepatology Associates, New York

10500

King Chulalongkorn Memorial Hospital, Bangkok

10700

Siriraj Hospital, Bangkok

10787

EPIMED GmbH, Berlin

13008

Hopital Saint Joseph, Marseille

16150

Hospital University Sains Malaysia, Kota Bharu

20016

Johns Hopkins Office of Capital Region Research - Sibley Memorial Hospital, Washington D.C.

20122

Irccs Ospedale Maggiore Di Milano, Milan

20146

ICH Study Center GmbH & Co. KG, Hamburg

21287

Johns Hopkins University, Baltimore

28041

Hosp. Univ. 12 de Octubre, Madrid

28222

Hospital Puerta De Hierro, Madrid

30625

Medizinische Hochschule Hannover, Hanover

32600

RESEARCH SITE s.r.o., Pilsen

34098

Istanbul University Cerrahpasa Medical Faculty, Istanbul

35033

Chu Rennes Hopital Pontchaillou, Rennes

35100

Ege University Medical of Faculty, Department of Gastroenterology, Izmir

38043

CHU de Grenoble Hopital Albert Michallon, Grenoble

39008

Hosp. Univ. Marques de Valdecilla, Santander

41126

Azienda Ospedaliero-Universitaria di Modena, Ospedale di Baggiovara, Modena

44093

CHU de Nantes hotel Dieu, Nantes

45147

Universitatsklinikum Essen, Essen

46014

Hosp. Gral. Univ. Valencia, Valencia

50200

Chiang Mai University Hospital, Chiang Mai

55131

Universitatsmedizin der Johannes Gutenberg Universitat Mainz, Mainz

56124

Azienda Ospedaliero Universitaria Pisana, Pisa

59100

University Malaya Medical Centre, Kuala Lumpur

60590

Universitätsklinikum Johann Wolfgang Goethe- Universität Frankfurt Medizinische Klinik 1, Frankfurt

61080

Karadeniz Teknik University Medical Faculty, Trabzon

63110

Washington University School Of Medicine, St Louis

68100

Hospital Selayang, Batu Caves

69004

Hopital de La Croix Rousse, Lyon

75012

Hopital Saint-Antoine, Paris

90036

Ruane Clinical Research Group Inc, Los Angeles

90110

Prince Of Songkla University, Songkhla

92110

Hopital Beaujon, Clichy

92673

Southern California GI and Liver Center, San Clemente

93301

The Office of Franco Felizarta, MD, Bakersfield

94800

Hopital Paul Brousse, Villejuif

98124

Azienda Ospedaliera Universitaria Policlinico G. Martino, Messina

121170

Clinic of the Modern Medicine, Moscow

190103

St. Petersburg City Center for AIDS and Infectious Diseases Treatment and Prophylaxis, Saint Petersburg

195067

Clinical Infectious Diseases Hospital n. a. S.P. Botkin, Saint Petersburg

196645

Republican Clinical Infectious Hospital, Saint Petersburg

214018

Smolensk Regional Clinical Hospital, Smolensk

355017

Stavropol State Medical University, Stavropol

443063

Medical Company Hepatolog Ltd, Samara

454092

Ural State Medical University, Chelyabinsk

510515

Nanfang Hospital, Guangzhou

620102

Sverdlovsk Regional Clinical Hospital #1, Yekaterinburg

630005

Medical Center SibNovoMed LLC, Novosibirsk

660049

Krasnoyarsk Regional Center For AIDS And Infectious Diseases Treatment And Prophylaxis, Krasnoyarsk

08844

I.D. Care, Inc., Hillsborough

69040-000

Fundacao de Medicina Tropical Doutor Heitor Vieira Dourado - FMT, Manaus

40110-060

Universidade Federal da Bahia - Hospital Professor Edgard Santos, Salvador

05403-000

Hospital Das Clinicas Da Faculdade De Medicina Da USP, São Paulo

T2N 4Z6

University of Calgary, Calgary

T6G 2G3

University of Alberta - Faculty of Medicine & Dentistry, Edmonton

V6Z 2K5

GI Research Institute (G.I.R.I.), Vancouver

V6Z2C7

Vancouver ID Research and Care Centre Society, Vancouver

ON M5G 2C4

Toronto General Hospital, Toronto

500 05

FN Hradec Kralove, Hradec Králové

120 00

KLIN MED s.r.o, Prague

140 21

IKEM, Prague

D-20246

University Medical Center, Hamburg

04103

Universitaetsklinikum Leipzig, Leipzig

Unknown

The University of Hong Kong, Hong Kong

The Chinese University of Hong Kong, Shatin

00161

Universita degli Studi di Roma 'La Sapienza' - Umberto I Policlinico di Roma, Rome

113 8519

Tokyo Medical and Dental University Hospital, Bunkyō City

260 8677

Chiba University Hospital, Chiba

918-8503

Fukui-ken Saiseikai Hospital, Fukui

721-8511

Fukuyama City Hospital, Fukuyama

734 8551

Hiroshima University Hospital, Hiroshima

760-8557

Kagawa Prefectural Central Hospital, Kagawa

634-8522

Nara Medical University Hospital, Kashihara

180-8610

Musashino Red Cross Hospital, Musashino

856-8562

National Hospital Organization Nagasaki Medical Center, Nagasaki

467 8602

Nagoya City University Hospital, Nagoya

663-8501

The Hospital of Hyogo College of Medicine, Nishinomiya

060-8648

Hokkaido University Hospital, Sapporo

565-0871

Osaka University Hospital, Suita-shi

105-8470

Toranomon Hospital, Tokyo

470-1192

Fujita Health University Hospital, Toyoake

05460

Hospital Sultanah Bahiyah, Alor Star

85-030

Wojewodzki Szpital Obserwacyjno-Zakazny im. Tadeusza Browicza w Bydgoszczy, Bydgoszcz

80-462

Neutrum Lekarze M.Hlebowicz i Partnerzy spolka partnerska, Gdansk

41-400

ID Clinic, Mysłowice

01-201

Wojewodzki Szpital Zakazny w Warszawie, Warsaw

50-136

SP ZOZ Wroclawskie Centrum Zdrowia, Wroclaw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08028

Hosp Clinic de Barcelona, Barcelona

06230

Hacettepe University Hospital, Ankara

06620

Ankara University Medical Faculty, Ankara

G12 0YN

NHS Greater Glasgow and Clyde - Gartnavel General Hospital, Glasgow

E1 1BB

Grahame Hayton Unit, London

SE5 9RF

Kings College Hospital, London

SW17 0RE

St Georges University of London and St George's University Hospitals NHS Foundation Trust, London

All Listed Sponsors
lead

Janssen Sciences Ireland UC

INDUSTRY

NCT03982186 - A Study of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection | Biotech Hunter | Biotech Hunter