37
Participants
Start Date
October 11, 2019
Primary Completion Date
February 13, 2023
Study Completion Date
June 9, 2023
Nivolumab
"Subjects will receive Nivolumab 360 mg every 3 weeks (Q3W) first day of each cycle plus Carboplatin area under the curve (AUC5) Q3W first day of each cycle plus Etoposide 100 day 1-3 of each cycle up to 6 cycles of combined therapy (Induction Phase).~At the time of completion of 6 cycles of chemotherapy and nivolumab, participants who have not experienced disease progression will continue to receive nivolumab at a dose of 480 mg as 30 minute infusion every 4 weeks for up to 2 years (24 months) (maintenance phase).~Cycles are defined by 4 weeks or 28 days."
Carboplatin
"Subjects will receive Nivolumab 360 mg every 3 weeks (Q3W) first day of each cycle plus Carboplatin AUC5 Q3W first day of each cycle plus Etoposide 100 day 1-3 of each cycle up to 6 cycles of combined therapy (Induction Phase).~At the time of completion of 6 cycles of chemotherapy and nivolumab, participants who have not experienced disease progression will continue to receive nivolumab at a dose of 480 mg as 30 minute infusion every 4 weeks for up to 2 years (24 months) (maintenance phase).~Cycles are defined by 4 weeks or 28 days."
Etoposide
"Subjects will receive Nivolumab 360 mg every 3 weeks (Q3W) first day of each cycle plus Carboplatin AUC5 Q3W first day of each cycle plus Etoposide 100 day 1-3 of each cycle up to 6 cycles of combined therapy (Induction Phase).~At the time of completion of 6 cycles of chemotherapy and nivolumab, participants who have not experienced disease progression will continue to receive nivolumab at a dose of 480 mg as 30 minute infusion every 4 weeks for up to 2 years (24 months) (maintenance phase).~Cycles are defined by 4 weeks or 28 days."
Institut Català d'Oncologia Badalona, Badalona
Institut Català d'Oncologia l'Hospitalet, L'Hospitalet de Llobregat
Vall d'Hebron University Hospital, Barcelona
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Hospital Universitario Ramón y Cajal, Madrid
MD Anderson Cancer Madrid, Madrid
Hospital Clínico Universitario Virgen de la Victoria, Málaga
Hospital Universitario Central de Asturias, Oviedo
Hospital Universitario Marqués de Valdecilla, Santander
Hospital Universitario Virgen del Rocío, Seville
Hospital Universitario Miguel Servet, Zaragoza
Grupo Espanol de Tumores Neuroendocrinos
OTHER