341
Participants
Start Date
July 25, 2019
Primary Completion Date
January 19, 2022
Study Completion Date
July 14, 2022
Elsubrutinib
Capsule; Oral
Placebo for elsubrutinib
Capsule; Oral
Upadacitinib
Film-coated tablet; Oral
Placebo for upadacitinib
Film-coated tablet; Oral
National Taiwan University Hospital /ID# 211752, Taipei
Linkou Chang Gung Memorial Hospital /ID# 211751, Taoyuan
Orszagos Reumatologiai es Fizioterapias Intezet /ID# 211827, Budapest
Aprillus Asistencia e Investigacion /ID# 211630, Ciudad Autonoma de Buenos Aire
Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich /ID# 221685, Ciudad Autonoma Buenos Aires
UMHAT Sveti Ivan Rilski /ID# 223139, Sofia
UMHAT Sveti Ivan Rilski /ID# 223140, Sofia
CER Instituto Medico /ID# 222757, Quilmes
Hospital Interzonal General de Agudos General Jose de San Martin /ID# 211679, La Plata
Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 211634, Rosario
Instituto CAICI S.R.L /ID# 211633, Rosario
Emeritus Research Sydney /ID# 222983, Botany
Middlemore Clinical Trials /ID# 213504, Papatoetoe
Royal North Shore Hospital /ID# 222982, St Leonards
St Vincent's Hospital Melbourne /ID# 212311, Fitzroy Melbourne
Emeritus Research /ID# 211903, Camberwell
Monash Medical Centre /ID# 212313, Clayton
Waikato Hospital /ID# 213505, Hamilton
Centro de Investigaciones Medicas Tucuman /ID# 212714, San Miguel de Tucumán
Investigaciones Clinicas Tucuman /ID# 211942, San Miguel de Tucumán
UMHAT Kaspela EOOD /ID# 223141, Plovdiv
Royal Brisbane and Women's Hospital /ID# 212667, Herston
Debreceni Egyetem Klinikai Kozpont /ID# 212042, Debrecen
Griffith University /ID# 223543, Southport
Rheumatology Research Unit Sunshine Coast /ID# 211902, Maroochydore
Hospital Cordoba /ID# 212200, Córdoba
The Queen Elizabeth Hospital /ID# 211901, Woodville South
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz /ID# 216971, Gyula
Vital Medical Center Orvosi es Fogaszati Kozpont /ID# 212796, Veszprém
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 211988, Berlin
Taipei Medical University Hospital /ID# 221600, Taipei
NYU Langone Ambulatory Care Brooklyn Heights /ID# 211548, Brooklyn
Taipei Veterans General Hosp /ID# 212216, Taipei
CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 211875, Mexico City
Hospital Universitario A Coruna - CHUAC /ID# 211719, A Coruña
Allegheny Health Network Research Institute /ID# 211607, Pittsburgh
Ajou University Hospital /ID# 211692, Suwon
Medstar Health Research Institute /ID# 213335, Washington D.C.
ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 215063, Milan
The Center for Rheumatology and Bone Research /ID# 211610, Wheaton
Inha University Hospital /ID# 211691, Incheon
Carilion Clinic /ID# 213500, Roanoke
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 212674, Kiel
Rheumatology and Pulmonary Clinic /ID# 211398, Beckley
Hospital Universitario 12 de Octubre /ID# 211757, Madrid
Millennium Research /ID# 219099, Ormond Beach
CHU Bordeaux - Hopital Pellegrin /ID# 211832, Bordeaux
Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 211858, Udine
LeJenue Research Associates /ID# 212327, Miami
Ctr Arthritis & Rheumatic Dise /ID# 212326, Miami
Arthritis & Rheumatic Disease Specialties /ID# 214052, Aventura
West Broward Rheumatology Associates /ID# 211881, Tamarac
IRIS Research and Development, LLC /ID# 213053, Plantation
Morales Vargas Centro de Investigacion S.C. /ID# 212946, León
Univ TN Health Sciences Ctr /ID# 212177, Memphis
Dr. Ramesh Gupta /ID# 213381, Memphis
Universitaetsklinikum Duesseldorf /ID# 212408, Düsseldorf
China Medical University Hospital /ID# 212179, Taichung
Taichung Veterans General Hospital /ID# 211957, Taichung
Hospital Universitario Virgen de Valme /ID# 212721, Seville
Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant Anna /ID# 211861, Cona
Centro Integral en Reumatologia S.A de C.V /ID# 211876, Guadalajara
Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 212532, Guadalajara
Hospital Universitario y Politecnico La Fe /ID# 211720, Valencia
Hospital Universitario Basurto /ID# 212722, Bilbao
Henry Ford Health System /ID# 211676, Detroit
June DO, PC /ID# 211674, Lansing
Hospital Universitario de Galdakao /ID# 212803, Galdakao
University of Iowa Hospitals and Clinics /ID# 215246, Iowa City
CHRU Lille - Hopital Claude Huriez /ID# 211829, Lille
Deerbrook Medical Associates /ID# 212251, Vernon Hills
Chonnam National University Hospital /ID# 211695, Gwangju
CHU Strasbourg - Hopital Civil /ID# 211981, Strasbourg
Trinity Universal Research Associates - Carrollton /ID# 211527, Carrollton
Hopital Pitie Salpetriere /ID# 211831, Paris
SW Rheumatology Res. LLC /ID# 211520, Mesquite
Accurate Clinical Management /ID# 213571, Houston
Centro de Alta Especialidad en Reumatología e Investigación del Potosí, SC /ID# 212737, San Luis Potosí City
Tekton Research, Inc. /ID# 211521, Austin
Tekton Research, Inc. /ID# 214182, Austin
West Texas Clinical Research /ID# 211529, Lubbock
Centro Integral de Reumatologia del Caribe Circaribe SAS /ID# 211894, Barranquilla
University of Colorado Hospital /ID# 211314, Aurora
Wallace Rheumatic Studies Center, LLC /ID# 211600, Beverly Hills
The Lundquist Institute at Harbor-UCLA Medical Center /ID# 213402, Torrance
Inland Rheum Clin Trials Inc. /ID# 213617, Upland
AP-HP - Hôpital Bicêtre /ID# 211968, Le Kremlin-Bicêtre
East Bay Rheumatology Medical /ID# 211638, San Leandro
Medical Care & Research SA de CV /ID# 212682, Mérida
Virginia Mason Medical Center /ID# 211457, Seattle
Peking Union Medical College Hospital /ID# 211614, Beijing
Centro de Investigacion en Reumatologia y Especialidades Medicas- CIREEM SAS /ID# 211895, Bogota
Huashan Hospital, Fudan University /ID# 213976, Shanghai
Shanghai Changhai Hospital /ID# 211819, Shanghai
Jiangsu Province Hospital /ID# 211818, Nanjing
Anhui Provincial Hospital /ID# 211812, Hefei
Preventive Care Sas /Id# 211896, Chía
Healthy Medical Center SAS /ID# 211899, Zipaquirá
Xiangya Hospital Central South University /ID# 212919, Changsha
Guangdong Provincial People's Hospital /ID# 211811, Guangzhou
People's Hospital of Xinjiang /ID# 211821, Ürümqi
Tohoku University Hospital /ID# 213693, Sendai
Arizona Arthritis & Rheumatology Research, PLLC /ID# 214522, Mesa
AZ Arthritis and Rheumotology Research, PLLC /ID# 211329, Phoenix
AZ Arthritis and Rheumotology Research, PLLC /ID# 214267, Phoenix
Arthritis and Rheumatism Associates /ID# 211411, Jonesboro
Arthritis & Osteo Medical Ctr /ID# 228235, La Palma
Valerius Medical Group & Research Center /ID# 211599, Los Alamitos
Medvin Clinical Research /ID# 211996, Tujunga
Yale University /ID# 212824, New Haven
BayCare Medical Group, Inc. /ID# 218818, Tampa
Affinity Clinical Research /ID# 211496, Oak Brook
Qualmedica Research, LLC /ID# 214765, Evansville
Beth Israel Deaconess Medical Center /ID# 212321, Boston
West County Rheumatology /ID# 225051, St Louis
NYU Langone Orthopedic Center /ID# 213620, New York
Ohio State University - Wexner Medical Center /ID# 211636, Columbus
STAT Research, Inc. /ID# 211404, Vandalia
Premier Rheumatology of Oklahoma /ID# 213850, Tulsa
Hamilton Health Sciences - McMaster University Medical Centre /ID# 212662, Hamilton
St. Josephs Health Care Centre /ID# 212331, London
Toronto Western Hospital /ID# 213336, Toronto
Diex Recherche Sherbrooke Inc. /ID# 217734, Sherbrooke
Clinica Universitaria Bolivari /ID# 211897, Medellín
Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 212770, Dresden
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 212195, Rome
Chukyo Hospital /ID# 222625, Nagoya
NHO Nagoya Medical Center /ID# 213974, Nagoya
Hamanomachi Hospital /ID# 213696, Fukuoka
Hospital of the University of Occupational and Environmental Health, Japan /ID# 217548, Kitakyushu-shi
Fukushima Medical University Hospital /ID# 213913, Fukushima
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 213694, Hiroshima
National Hospital Organization Asahikawa Medical Center /ID# 213846, Asahikawa-shi
Tomakomai City Hospital /ID# 214234, Tomakomai-shi
Kita-harima Medical Center /ID# 215474, Ono-shi
EIRAKU Internal Medicine Clinic /ID# 215419, Kagoshima
Yokohama Rosai Hospital /ID# 213690, Yokohama
Kumamoto Shinto General Hospital /ID# 215347, Kumamoto
Shinshu University Hospital /ID# 213853, Matsumoto-shi
Nagano Red Cross Hospital /ID# 214572, Nagano
Saitama Medical Center /ID# 213687, Kawagoe-shi
Keio University Hospital /ID# 216347, Shinjuku-ku
RM Pharma Specialists S.A de C.V. /ID# 211879, Mexico City
Vrije Universiteit Medisch Centrum /ID# 214424, Amsterdam
Leids Universitair Medisch Centrum /ID# 214413, Leiden
Universitair Medisch Centrum Utrecht /ID# 214415, Utrecht
North Shore Hospital /ID# 213506, Takapuna
Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi /ID# 212483, Poznan
Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 212146, Krakow
WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 212482, Wroclaw
Centrum Medyczne Pratia Warszawa /ID# 218176, Warsaw
GCM Medical Group PSC /ID# 211251, San Juan
Mindful Medical Research /ID# 213384, San Juan
KonKuk University Medical Center /ID# 213410, Seoul
Seoul National University Hospital /ID# 211740, Seoul
HUA - Txagorritxu /ID# 212520, Vitoria-Gasteiz
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 212145, Sabadell
Guys and St Thomas NHS Foundation Trust /ID# 211931, London
Cambridge University Hospitals NHS Foundation Trust /ID# 213189, Cambridge
Manchester University NHS Foundation Trust /ID# 211838, Manchester
Lead Sponsor
AbbVie
INDUSTRY