A Study of Pembrolizumab (MK-3475) With or Without Maintenance Olaparib in First-line Metastatic Squamous Non-small Cell Lung Cancer (NSCLC, MK-7339-008/KEYLYNK-008)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

851

Participants

Timeline

Start Date

June 28, 2019

Primary Completion Date

September 21, 2023

Study Completion Date

January 30, 2026

Conditions
Carcinoma, Squamous Cell, Non-small-cell Lung
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Carboplatin

IV infusion

DRUG

Paclitaxel

IV infusion

DRUG

Nab-paclitaxel

IV infusion

DRUG

Olaparib

Tablets

DRUG

Placebo

Placebo to olaparib, tablets

Trial Locations (178)

104

Mackay Memorial Hospital ( Site 0902), Taipei

333

Chang Gung Medical Foundation.Linkou Branch ( Site 0903), Taoyuan District

704

National Cheng Kung University Hospital ( Site 0905), Tainan City

1145

Social Medical Center - Otto Wagner Hospital ( Site 1301), Vienna

1210

Krankenhaus Nord - Klinik Floridsdorf ( Site 1300), Vienna

2170

Liverpool Hospital ( Site 1201), Liverpool

2500

Southern Medical Day Care Centre ( Site 1200), Wollongong

3168

Monash Cancer Centre ( Site 1205), Clayton

4020

Ordensklinikum Linz GmbH Elisabethinen ( Site 1307), Linz

4414

MidCentral DHB Palmerston North Hospital ( Site 1102), Palmerston North

4600

Klinikum Wels-Grieskirchen ( Site 1304), Wels

4814

Townsville General Hospital ( Site 1202), Townsville

6020

Innsbruck LKH ( Site 1302), Innsbruck

6021

Capital & Coast District Health Board - Wellington Hospital ( Site 1101), Wellington

10048

National Taiwan University Hospital ( Site 0900), Taipei

10408

National Cancer Center ( Site 1006), Goyang-si

14033

CHU Caen ( Site 1406), Caen

16247

The Catholic University of Korea St. Vincent s Hospital ( Site 1003), Gyeonggi-do

16499

Ajou University Hospital ( Site 1004), Suwon

18009

Cherkasy Regional Oncology Dispensary ( Site 2225), Cherkasy

21237

MedStar Franklin Square Medical Center ( Site 0044), Baltimore

22087

Katholisches Marienkrankenhaus gGmbH ( Site 1572), Hamburg

23007

Complejo Hospitalario de Jaen ( Site 1713), Jaén

23040

Investigacion Onco Farmaceutica S de RL de CV ( Site 0300), La Paz

25006

PP PPC Acinus Medical and Diagnostic Centre ( Site 2223), Kropyvnytskyi

27518

Waverly Hematology Oncology ( Site 0054), Cary

28041

Hospital Universitario 12 de Octubre ( Site 1716), Madrid

28644

Chungbuk National University Hospital ( Site 1002), Cheongju-si

29010

Complejo Hospitalario de Malaga ( Site 1714), Málaga

31904

Columbus Regional Research Institute ( Site 0099), Columbus

32763

Mid-Florida Cancer Centers ( Site 0022), Orange City

33486

Boca Raton Regional Hospital ( Site 0018), Boca Raton

33612

H. Lee Moffitt Cancer Center and Research Institute ( Site 0024), Tampa

34093

Bezmialem Vakif Univ. Tıp Fakultesi Hastanesi Tibbi Onkoloji Bolumu ( Site 2107), Istanbul

34376

Pneumologische Lehrklinik Universitaet Goettingen ( Site 1551), Immenhausen

34722

Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2103), Istanbul

35040

Ege Universitesi Tip Fakultesi ( Site 2109), Izmir

35205

Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham

37075

Universitaetsmedizin Goettingen ( Site 1557), Göttingen

37804

Thompson Cancer Survival Center ( Site 2812), Knoxville

38039

Erciyes Universitesi Tip Fakultesi ( Site 2108), Kayseri

39401

Hattiesburg Clinic ( Site 0051), Hattiesburg

40447

China Medical University Hospital ( Site 0904), Taichung

41009

Hospital Universitario Virgen Macarena ( Site 1712), Seville

44280

Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0334), Guadalajara

45136

Kliniken Essen Mitte ( Site 1567), Essen

46410

Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0039), Merrillville

48201

Barbara Ann Karmanos Cancer Institute ( Site 0046), Detroit

49100

CHU Angers ( Site 1405), Angers

49102

City Clinical Hosp.4 of DCC ( Site 2215), Dnipro

52727

Gyeongsang National University Hospital ( Site 1005), Jinju

53105

Universitaetsklinikum Bonn ( Site 1574), Bonn

54519

Institut De Cancerologie De Lorraine ( Site 1409), Vandœuvre-lès-Nancy

55270

Ondokuz Mays Üniversitesi Tp Fakültesi Hastanesi-Oncology ( Site 2106), Samsun

56068

InVo-Institut fuer Versorgungsforschung in der Onkologie ( Site 1564), Koblenz

57070

Hopital Robert Schuman ( Site 1402), Vantoux

59100

Namik Kemal Universitesi Tip Fakultesi ( Site 2100), Tekirdağ

59102

Frontier Oncology ( Site 0052), Billings

59715

Bozeman Health Deaconness Cancer Center ( Site 0053), Bozeman

60008

Oncology of Northshore ( Site 0036), Rolling Meadows

60590

Universitaetsklinikum Frankfurt ( Site 1563), Frankfurt am Main

60608

Mount Sinai Hospital Medical Center ( Site 0035), Chicago

61024

Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2226), Kharkiv

61070

Regional Centre of Oncology-Thoracic organs ( Site 2219), Kharkiv

63011

Centre Jean Perrin ( Site 1407), Clermont-Ferrand

63739

Studienzentrum Aschaffenburg ( Site 1575), Aschaffenburg

64000

Centre Hospitalier de Pau ( Site 1412), Pau

64060

Axis Heilsa S. de R.L. de C.V. ( Site 0301), Monterrey

65055

MI Odessa Regional Oncological Centre ( Site 2222), Odesa

76000

CHU de Rouen ( Site 1403), Rouen

76018

MI Precarpathian Clinical Oncology Center ( Site 2218), Ivano-Frankivsk

77380

Renovatio Clinical ( Site 0074), The Woodlands

80336

Klinikum der LMU ( Site 1550), Munich

81925

Klinikum Bogenhausen Staedt. Klinikum Muenchen GmbH ( Site 1573), Munich

83301

Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0907), Kaohsiung City

88000

Central City Clinical Hospital ( Site 2221), Uzhhorod

91505

Disney Family Cancer Center ( Site 0005), Burbank

91900

FAICIC Clinical Research ( Site 0303), Veracruz

93042

Universitaetsklinikum Regensburg ( Site 1562), Regensburg

94163

Hopital d'Instruction des Armees Begin ( Site 1413), Saint-Mandé

94300

CLIMERS Clinical Medical Research ( Site 0306), Orizaba

97074

Klinikum Wuerzburg Mitte gGmbH ( Site 1559), Würzburg

99089

Helios Klinikum Erfurt GmbH ( Site 1552), Erfurt

99216

Cancer Care Northwest ( Site 0083), Spokane Valley

115478

Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 2000), Moscow

119991

First Moscow State Medical University n.a. I.M.Sechenov ( Site 2024), Moscow

125284

Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2009), Moscow

125367

FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 2006), Moscow

143900

Moscow Regional Oncological Dispensary ( Site 2028), Balashikha

194291

SBHI Leningrad Regional Clinical Hospital ( Site 2002), Saint Petersburg

195271

SPb Central Clinical Railway Hospital ( Site 2003), Saint Petersburg

197758

National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 2004), Saint Petersburg

198255

SPb SBHI City Clinical Oncological Dispensary ( Site 2001), Saint Petersburg

200347

S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2508), Craiova

300239

Policlinica Oncomed SRL ( Site 2505), Timișoara

400015

Cardiomed SRL Cluj-Napoca ( Site 2504), Cluj-Napoca

407280

S.C. Radiotherapy Center Cluj S.R.L ( Site 2507), Cluj-Napoca

420029

Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2021), Kazan'

443031

SBHI Samara Regional Clinical Oncology Dispensary ( Site 2016), Samara

603081

Nizhniy Novgorod Region Oncology Dispensary ( Site 2026), Nizhny Novgorod

644013

Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site, Omsk

900591

Spitalul Clinic Judetean de Urgenta Sf Apostol Andrei ( Site 2501), Constanța

B8001HXM

Hospital Italiano Regional del Sur ( Site 0509), Bahía Blanca

B7600FZO

Instituto de Investigaciones Clinicas Mar del Plata ( Site 0516), Mar del Plata

C1280AEB

Hospital Britanico de Buenos Aires ( Site 0500), Buenos Aires

X5800AEV

Instituto Medico Rio Cuarto ( Site 0501), Río Cuarto

S2000DSV

Sanatorio Parque ( Site 0515), Rosario

S2000KZE

Centro Oncológico de Rosario ( Site 0507), Rosario

T4000IAK

Centro Medico San Roque ( Site 0506), San Miguel de Tucumán

C1199ABB

Hospital Italiano de Buenos Aires ( Site 0511), Buenos Aires

X5004FHP

Clínica Universitaria Reina Fabiola ( Site 0505), Córdoba

S3000AOL

Sanatorio Privado San Geronimo S.R.L ( Site 0510), Santa Fe

60430-230

Instituto do Cancer do Ceara ( Site 0251), Fortaleza

41253-190

Hospital Sao Rafael ( Site 0258), Salvador - BA

66053-000

Oncologica do Brasil ( Site 0256), Belém

95700-000

Hospital Tacchini ( Site 0265), Bento Gonçalves

90050-170

Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0255), Porto Alegre

88301-220

Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0252), Itajaí

15090-000

Hospital de Base de Sao Jose de Rio Preto ( Site 0254), Sao Jose Rio Preto

20230-130

Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0253), Rio de Janeiro

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0250), São Paulo

01321-001

Hospital Paulistano - Amil Clinical Research ( Site 0263), São Paulo

Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0260), São Paulo

B3H 1V7

Nova Scotia Health Authority ( Site 0103), Halifax

L8V5C2

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0107), Hamilton

K7L 2V7

Kingston Health Sciences Centre ( Site 0102), Kingston

L3Y 2P9

Stronach Regional Cancer Centre ( Site 0100), Newmarket

J4V 2H1

CISSS de la Monteregie-Centre ( Site 0101), Greenfield Park

H7M 3L9

Hopital Cite de la Sante de Laval ( Site 0105), Laval

H3T 1M5

CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0110), Montreal

G8Z 3R9

CIUSSS de la Mauricie et du Centre du Quebec ( Site 0106), Trois-Rivières

02300

Centre Hospitalier De Chauny ( Site 1411), Chauny

460-0001

National Hospital Organization Nagoya Medical Center ( Site 0806), Nagoya

464-8681

Aichi Cancer Center Hospital ( Site 0803), Nagoya

277-8577

National Cancer Center Hospital East ( Site 0801), Kashiwa

830-0011

Kurume University Hospital ( Site 0814), Kurume

920-8641

Kanazawa University Hospital ( Site 0811), Kanazawa

241-8515

Kanagawa Cancer Center ( Site 0807), Yokohama

980-0873

Sendai Kousei Hospital ( Site 0812), Sendai

573-1191

Kansai Medical University Hospital ( Site 0804), Hirakata

591-8555

National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0813), Sakai

411-8777

Shizuoka Cancer Center Hospital and Research Institute ( Site 0802), Sunto-gun

810-8563

National Hospital Organization Kyushu Medical Center ( Site 0805), Fukuoka

951-8566

Niigata Cancer Center Hospital ( Site 0808), Niigata

700-8558

Okayama University Hospital ( Site 0810), Okayama

541-8567

Osaka International Cancer Institute ( Site 0809), Osaka

135-8550

The Cancer Institute Hospital of JFCR ( Site 0800), Tokyo

06700

Arke Estudios Clinicos ( Site 0333), Mexico City

62-500

Przychodnia Lekarska Komed ( Site 2416), Konin

60-693

MED-POLONIA Sp. z o.o. ( Site 2419), Poznan

31-202

Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 2420), Krakow

10-357

Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc ( Site 2417), Olsztyn

59-900

Wielospecjalistyczny Szpital SPZOZ w Zgorzelcu ( Site 2404), Zgorzelec

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warsaw

47-400

Szpital Rejonowy im. dr Jozefa Rostka ( Site 2402), Racibórz

022548

S.C.Focus Lab Plus S.R.L ( Site 2502), Bucharest

05505

Asan Medical Center ( Site 1007), Songpa-gu

03080

Seoul National University Hospital ( Site 1000), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 1001), Seoul

08308

Korea University Guro Hospital ( Site 1008), Seoul

08908

Hospital Duran i Reynals ( Site 1710), L'Hospitalet de Llobregat

08041

Hospital Sant Creu i Sant Pau ( Site 1711), Barcelona

01120

Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 2101), Adana

06500

Gazi Universitesi Tip Fakultesi ( Site 2104), Ankara

06800

Ankara Sehir Hastanesi ( Site 2105), Ankara

08173

Medical Center Asklepion LLC ( Site 2243), Khodosovka

03115

Kyiv City Clinical Oncology Centre ( Site 2224), Kyiv

03126

Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2227), Kyiv

03039

Medical Center Verum ( Site 2228), Kyiv

SS0 0RY

Southend University Hospital NHS Foundation Trust ( Site 1913), Westcliff-on-Sea

EC1M 6BQ

Barts Health NHS Trust - St Bartholomew s Hospital ( Site 1923), London

SW10 9NH

Chelsea and Westminster Hospital ( Site 1901), London

NE7 7DN

Newcastle Freeman Hospital ( Site 1902), Newcastle upon Tyne

IP33 2QZ

West Suffolk Hospitals NHS Trust ( Site 1919), Bury St Edmunds

EH4 2XU

Western General Hospital, Edinburgh ( Site 1924), Edinburgh

SA2 8QA

Singleton Hospital ( Site 1909), Swansea

CO4 5JL

Colchester General Hospital ( Site 1911), Colchester

B9 5SS

Birmingham Heartlands Hospital ( Site 1910), Birmingham

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY