Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,003

Participants

Timeline

Start Date

June 28, 2019

Primary Completion Date

February 7, 2024

Study Completion Date

January 30, 2026

Conditions
Carcinoma, Nonsquamous Non-small-cell Lung
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Pemetrexed

IV infusion

DRUG

Carboplatin

IV infusion

DRUG

Cisplatin

IV infusion

DRUG

Olaparib

Oral Tablet

Trial Locations (178)

100

National Taiwan University Hospital ( Site 0900), Taipei

104

Mackay Memorial Hospital ( Site 0902), Taipei

333

Chang Gung Medical Foundation.Linkou Branch ( Site 0903), Taoyuan District

833

Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0907), Kaohsiung City

1145

Social Medical Center - Otto Wagner Hospital ( Site 1301), Vienna

1210

Krankenhaus Nord - Klinik Floridsdorf ( Site 1300), Vienna

2170

Liverpool Hospital ( Site 1201), Liverpool

2500

Southern Medical Day Care Centre ( Site 1200), Wollongong

3168

Monash Cancer Centre ( Site 1205), Clayton

4020

Ordensklinikum Linz GmbH Elisabethinen ( Site 1307), Linz

4414

MidCentral DHB Palmerston North Hospital ( Site 1102), Palmerston North

4600

Klinikum Wels-Grieskirchen ( Site 1304), Wels

4814

Townsville General Hospital ( Site 1202), Townsville

6020

Innsbruck LKH ( Site 1302), Innsbruck

6021

Capital & Coast District Health Board - Wellington Hospital ( Site 1101), Wellington

10408

National Cancer Center ( Site 1006), Goyang-si

14033

CHU Caen ( Site 1406), Caen

16247

The Catholic University of Korea St. Vincent s Hospital ( Site 1003), Suwon

16499

Ajou University Hospital ( Site 1004), Suwon

18009

Cherkasy Regional Oncology Dispensary ( Site 2211), Cherkasy

21239

Medstar Good Samaritan Hospital ( Site 0040), Baltimore

22087

Katholisches Marienkrankenhaus gGmbH ( Site 1522), Hamburg

25006

PP PPC Acinus Medical and Diagnostic Centre ( Site 2209), Kropyvnitskiy

27518

Waverly Hematology Oncology ( Site 0081), Cary

28223

Hospital Universitario Quiron Madrid ( Site 1701), Pozuelo de Alarcón

28644

Chungbuk National University Hospital ( Site 1002), Cheongju-si

31904

Columbus Regional Research Institute ( Site 0098), Columbus

32763

Mid-Florida Cancer Centers ( Site 0022), Orange City

33486

Boca Raton Regional Hospital ( Site 0018), Boca Raton

33612

Moffitt Cancer Center ( Site 0024), Tampa

34093

Bezmialem Vakif Univ. Tıp Fakultesi Hastanesi Tibbi Onkoloji Bolumu ( Site 2107), Istanbul

34376

Pneumologische Lehrklinik Universitaet Goettingen ( Site 1501), Immenhausen

34722

Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2103), Istanbul

35040

Ege Universitesi Tip Fakultesi ( Site 2109), Izmir

35205

Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham

35661

Northwest Alabama Cancer Center, PC ( Site 0002), Muscle Shoals

37075

Universitaetsmedizin Goettingen ( Site 1507), Göttingen

37916

Thompson Cancer Survival Center ( Site 2812), Knoxville

37920

University of Tennessee Medical Center Knoxville ( Site 0060), Knoxville

38039

Erciyes Universitesi Tip Fakultesi ( Site 2108), Kayseri

39401

Hattiesburg Clinic ( Site 0045), Hattiesburg

40447

China Medical University Hospital ( Site 0904), Taichung

41014

Hospital Universitario Nuestra Senora de Valme ( Site 1703), Seville

45136

Kliniken Essen Mitte ( Site 1517), Essen

46010

Hospital Clinico Universitario de Valencia ( Site 1706), Valencia

46410

Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0036), Merrillville

48201

Barbara Ann Karmanos Cancer Institute ( Site 0041), Detroit

49100

CHU Angers ( Site 1405), Angers

49102

Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council ( Site 2201), Dnipro

50009

Hospital Clinico Lozano Blesa ( Site 1700), Zaragoza

52727

Gyeongsang National University Hospital ( Site 1005), Jinju

53127

Universitaetsklinikum Bonn ( Site 1524), Bonn

54519

Institut De Cancerologie De Lorraine ( Site 1409), Vandœuvre-lès-Nancy

55139

Ondokuz Mayıs Universitesi-Oncology department ( Site 2106), Samsun

56068

InVo-Institut fuer Versorgungsforschung in der Onkologie ( Site 1514), Koblenz

57070

Hopital Robert Schuman ( Site 1402), Vantoux

59100

Namik Kemal Universitesi Tip Fakultesi ( Site 2100), Tekirdağ

59102

Frontier Oncology ( Site 0080), Billings

59715

Bozeman Health Deaconness Cancer Center ( Site 0046), Bozeman

60008

Oncology of Northshore ( Site 0033), Rolling Meadows

60590

Universitaetsklinikum Frankfurt ( Site 1513), Frankfurt am Main

60608

Mount Sinai Hospital Medical Center ( Site 0032), Chicago

61024

Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2212), Kharkiv

61070

"CNPE Regional Center of Oncology-Thoracic organs ( Site 2205)", Kharkiv

63011

Centre Jean Perrin ( Site 1407), Clermont-Ferrand

63739

Studienzentrum Aschaffenburg ( Site 1525), Aschaffenburg

64000

Centre Hospitalier de Pau ( Site 1412), Pau

65055

MI Odessa Regional Oncological Centre ( Site 2208), Odesa

70457

National Cheng Kung University Hospital ( Site 0905), Tainan City

76000

CHU de Rouen ( Site 1403), Rouen

76018

MI Precarpathian Clinical Oncology Center ( Site 2204), Ivano-Frankivsk

77380

Renovatio Clinical ( Site 0062), The Woodlands

80336

Klinikum der LMU ( Site 1500), Munich

81925

Klinikum Bogenhausen Staedt. Klinikum Muenchen GmbH ( Site 1523), Munich

88000

Central City Clinical Hospital ( Site 2207), Uzhhorod

91505

Disney Family Cancer Center ( Site 0005), Burbank

93053

Universitaetsklinikum Regensburg ( Site 1512), Regensburg

94163

Hopital d'Instruction des Armees Begin ( Site 1413), Saint-Mandé

97074

Klinikum Wuerzburg Mitte gGmbH ( Site 1509), Würzburg

99089

Helios Klinikum Erfurt GmbH ( Site 1502), Erfurt

99216

Cancer Care Northwest ( Site 0071), Spokane Valley

110221

Administradora Country S.A. ( Site 0603), Bogotá

111321

Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0601), Bogotá

115478

Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 2000), Moscow

119991

First Moscow State Medical University n.a. I.M.Sechenov ( Site 2024), Moscow

125284

Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2009), Moscow

125367

FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 2006), Moscow

143900

Moscow Regional Oncological Dispensary ( Site 2028), Balashikha

194291

SBHI Leningrad Regional Clinical Hospital ( Site 2002), Saint Petersburg

195271

SPb Central Clinical Railway Hospital ( Site 2003), Saint Petersburg

197758

National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 2004), Saint Petersburg

198255

SPb SBHI City Clinical Oncological Dispensary ( Site 2001), Saint Petersburg

200542

S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2508), Craiova

300239

Policlinica Oncomed SRL ( Site 2505), Timișoara

400015

Cardiomed SRL Cluj-Napoca ( Site 2504), Cluj-Napoca

407280

S.C. Radiotherapy Center Cluj S.R.L ( Site 2507), Cluj-Napoca

420029

Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 2021), Kazan'

443031

SBHI Samara Regional Clinical Oncology Dispensary ( Site 2016), Samara

500152

Spitalul PDR Medlife ( Site 2509), Brasov

603081

Nizhniy Novgorod Region Oncology Dispensary ( Site 2026), Nizhny Novgorod

644013

Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site 2010), Omsk

905900

Ovidius Clinical Hospital OCH ( Site 2501), Ovidiu

2778577

National Cancer Center Hospital East ( Site 0801), Kashiwa

8108563

National Hospital Organization Kyushu Medical Center ( Site 0805), Fukuoka

B8001HXM

Hospital Italiano Regional del Sur ( Site 0509), Bahía Blanca

C1199ABB

Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0511), Ciudad Autonoma de Buenos Aires

C1280AEB

Hospital Britanico de Buenos Aires ( Site 0500), Ciudad Autónoma de Buenos Aires

X5800AEV

Instituto Medico Rio Cuarto ( Site 0501), Río Cuarto

S2000KZE

Centro Oncológico de Rosario ( Site 0507), Rosario

T4000IAK

Centro Medico San Roque ( Site 0506), San Miguel de Tucumán

X5004SHP

Clínica Universitaria Reina Fabiola ( Site 0505), Córdoba

S3000AOL

Sanatorio Privado San Geronimo S.R.L ( Site 0510), Santa Fe

60351-030

Instituto do Cancer do Ceara ( Site 0201), Fortaleza

41253-190

Hospital Sao Rafael ( Site 0212), Salvador

66053-000

Oncologica do Brasil ( Site 0210), Belém

95700-000

Hospital Tacchini ( Site 0208), Bento Gonçalves

90050-170

Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0209), Porto Alegre

96810-110

Saint Gallen Instituto de Oncologia ( Site 0206), Santa Cruz do Sul

88020-210

YNOVA Pesquisa Clinica ( Site 0215), Florianópolis

88301-220

Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0202), Itajaí

89201-260

Centro de Hematologia e Oncologia ( Site 0205), Joinville

15080-000

Hospital de Base de Sao Jose de Rio Preto ( Site 0204), Sao Jose Rio Preto

20231-050

Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0203), Rio de Janeiro

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0200), São Paulo

01321-001

BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0214), São Paulo

Hospital Paulistano - Amil Clinical Research ( Site 0207), São Paulo

V7L 2L7

Lions Gate Hospital ( Site 0106), North Vancouver

V8R 6V5

BC Cancer - Victoria ( Site 0109), Victoria

B3H 2Y9

Queen Elizabeth II Health Sciences Centre ( Site 0107), Halifax

P3E 5J1

Health Sciences North Research Institute ( Site 0115), Greater Sudbury

N2G 1G3

Waterloo Regional Health Network (WRHN) ( Site 0117), Kitchener

L3Y 2P9

Stronach Regional Cancer Centre ( Site 0101), Newmarket

J4V 2H1

CISSS de la Monteregie-Centre ( Site 0114), Greenfield Park

H2X 3E4

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0105), Montreal

H3T 1M5

CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0110), Montreal

G5L 5T1

Centre de Sante et des Services Sociaux de Rimouski-Neigette ( Site 0104), Rimouski

J1H 5N4

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0103), Sherbrooke

050030

Fundacion Colombiana de Cancerologia Clinica Vida ( Site 0604), Medellín

080020

Clinica de la Costa S.A.S. ( Site 0608), Barranquilla

02300

Centre Hospitalier De Chauny ( Site 1411), Chauny

460-0001

National Hospital Organization Nagoya Medical Center ( Site 0806), Nagoya

464-8681

Aichi Cancer Center ( Site 0803), Nagoya

920-8641

Kanazawa University Hospital ( Site 0811), Kanazawa

241-8515

Kanagawa Cancer Center ( Site 0807), Yokohama

981-0914

Sendai Kousei Hospital ( Site 0812), Sendai

573-1191

Kansai Medical University Hospital ( Site 0804), Hirakata

591-8555

National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0813), Sakai

411-8777

Shizuoka Cancer Center ( Site 0802), Suntogun

951-8566

Niigata Cancer Center Hospital ( Site 0808), Niigata

700-8558

Okayama University Hospital ( Site 0810), Okayama

541-8567

Osaka International Cancer Institute ( Site 0809), Osaka

135-8550

Cancer Institute Hospital of JFCR ( Site 0800), Tokyo

62-500

Przychodnia Lekarska Komed ( Site 2416), Konin

61-693

MED-POLONIA Sp. z o.o. ( Site 2419), Poznan

31-202

Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 2420), Krakow

59-900

Wielospecjalistyczny Szpital SPZOZ w Zgorzelcu ( Site 2404), Zgorzelec

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2418), Warsaw

47-400

Szpital Rejonowy im. dr Jozefa Rostka ( Site 2402), Racibórz

10-357

Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 2417), Olsztyn

013823

MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2502), Bucharest

05505

Asan Medical Center ( Site 1007), Songpa-gu

03080

Seoul National University Hospital ( Site 1000), Seoul

08308

Korea University Guro Hospital ( Site 1008), Seoul

08003

Hospital del Mar ( Site 1702), Barcelona

01120

Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 2101), Adana

06500

Gazi Universitesi Tip Fakultesi ( Site 2104), Ankara

06800

Ankara Bilkent Sehir Hastanesi ( Site 2105), Ankara

08173

Medical Center Asklepion LLC ( Site 2234), Khodosovka

03039

Medical Center Verum ( Site 2230), Kyiv

03126

Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2213), Kyiv

03115

Kyiv City Clinical Oncology Centre ( Site 2210), Kyiv

EC1M 6BQ

Barts Health NHS Trust - St Bartholomew s Hospital ( Site 1923), London

SW10 9NH

Chelsea and Westminster Hospital ( Site 1901), London

IP33 2QZ

West Suffolk Hospitals NHS Trust ( Site 1919), Bury St Edmunds

EH4 2XU

Western General Hospital, Edinburgh ( Site 1924), Edinburgh

SA2 8QA

Singleton Hospital ( Site 1909), Swansea

CO4 5JL

Colchester General Hospital ( Site 1911), Colchester

B9 5SS

Birmingham Heartlands Hospital ( Site 1910), Birmingham

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

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