A Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache

PHASE4CompletedINTERVENTIONAL
Enrollment

620

Participants

Timeline

Start Date

October 7, 2019

Primary Completion Date

December 1, 2022

Study Completion Date

June 13, 2023

Conditions
Migraine Headache
Interventions
DRUG

Erenumab 70 mg

Erenumab once every 4 weeks. Subcutaneous injection.

DRUG

Erenumab 140 mg

Erenumab once every 4 weeks. Subcutaneous injection.

DRUG

Placebo

Placebo once every 4 weeks. Subcutaneous injection.

Trial Locations (94)

1036

Obudai Egeszsegugyi Centrum Kft, Budapest

1090

Universitaetsklinikum Allgemeines Krankenhaus Wien, Vienna

1123

Swiss Premium Egeszsegkozpont, Budapest

1145

Orszagos Mentalis, Ideggyogyaszati es Idegsebeszeti Intezet, Budapest

1204

Jahn Ferenc Del-pesti Korhaz es Rendelointezet, Budapest

2010

Holdsworth House Medical Practice, Sydney

3004

The Alfred Hospital, Melbourne

3526

Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz, Miskolc

4021

Konventhospital der Barmherzigen Brueder Linz, Linz

4026

Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz, Debrecen

6020

Medizinische Universitaet Innsbruck, Innsbruck

6725

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar, Szeged

9020

Klinikum Klagenfurt am Woerthersee, Klagenfurt

13385

Hopital La Timone, Marseille

14226

Dent Neurosciences Research Center, Amherst

15224

Allegheny Health Network Cancer Institute at Mellon Pavilion, Pittsburgh

15236

Preferred Primary Care Physicians, Inc, Pittsburgh

20037

The George Washington Medical Faculty Associates, Washington D.C.

20100

Terveystalo Pulssi, Turku

20133

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan

25701

Marshall University, Huntington

27100

Fondazione Istituto Neurologico Nazionale C Mondino IRCCS, Pavia

28277

Onsite Clinical Solutions LLC, Charlotte

32504

Emerald Coast Center for Neurological Disorders, Pensacola

32801

Clinical Neuroscience Solutions, Orlando

33016

Floridian Clinical Research LLC, Miami Lakes

33100

Suomen Terveystalo, Tampere

33136

University of Miami Miller School of Medicine, Miami

33612

University of South Florida, Tampa

37203

Nashville Neuroscience Group, Nashville

40139

IRCCS Istituto delle Scienze Neurologiche di Bologna Ospedale Bellaria, Bologna

40536

University of Kentucky, Lexington

41013

Hospital Universitario Virgen del Rocio, Seville

42055

Centre Hospitalier Universitaire Saint-Etienne - Hopital Nord, Saint-Etienne

44195

Cleveland Clinic, Cleveland

45212

Clinical Trial Investigator Clinical Research Center, Cincinnati

46010

Hospital Clinico Universitario de Valencia, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

46804

Fort Wayne Neurological Center, Fort Wayne

47010

Hospital Clinico Universitario de Valladolid, Valladolid

48104

Michigan Head Pain and Neurological Institute, Ann Arbor

50009

Hospital Clinico Universitario Lozano Blesa, Zaragoza

50134

Azienda Ospedaliera Universitaria Careggi, Florence

54311

Aurora BayCare Medical Center, Green Bay

55402

Clinical Research Institute Inc, Minneapolis

59037

Centre Hospitalier Regional Universitaire de Lille - Hopital Roger Salengro, Lille

63141

Mercy Research, St Louis

65613

Citizens Memorial Healthcare, Bolivar

66208

Collective Medical Research, Prairie Village

66212

College Park Family Care Center, Overland Park

69677

Hospices Civils de Lyon - Hopital neurologique Pierre Wertheimer, Bron

70124

DelRicht Research, New Orleans

74374

Centre Hospitalier Annecy Genevois, Pringy

75010

Hopital Lariboisiere, Paris

75014

Groupe hospitalier Paris Saint Joseph, Paris

75214

Texas Neurology, PA, Dallas

83642

Saint Lukes Clinic, Meridian

84107

Wasatch Clinical Research LLC, Salt Lake City

86021

Centre Hospitalier Universitaire de Poitiers, Poitiers

88100

Azienda Ospedaliero Universitaria Mater Domini, Catanzaro

90048

Clinical Research Institute, Los Angeles

90127

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo

90590

Northern Cinical Trial Coordinators, Oulu

90703

Core Healthcare Group, Cerritos

92324

Axiom Research, Colton

02035

Neurology Center of New England PC, Foxborough

03756

Dartmouth Hitchcock Medical Center, Lebanon

616 00

Neurologie Brno sro, Brno

656 91

Fakultni nemocnice u svate Anny v Brne, Brno

120 00

Dado Medical sro, Prague

140 59

Thomayerova nemocnice, Prague

186 00

INEP, Prague

750 02

Mudr Stanislav Bartek sro, Přerov

516 01

Vestra Clinics sro, Rychnov nad Kněžnou

00930

Helsingin Paansarkykeskus Aava, Helsinki

06003

Centre Hospitalier Universitaire de Nice - Hopital de Cimiez, Nice

00163

IRCCS San Raffaele Pisana, Roma

95-054

Centrum Opieki Zdrowotnej Orkan-Med Stec-Michalska Spolka Jawna, Ksawerów

05-120

Jerzy Petz Mediq Niepubliczny Zaklad Opieki Zdrowotnej, Legionowo

90-338

Gabinet Lekarski Jacek Rozniecki, Lodz

60-848

Clinical Research Center Spzoo Medic-R Spolka Komandytowa, Poznan

96-500

RCMed Oddzial Sochaczew, Sochaczew

2720-276

Hospital Professor Doutor Fernando Fonseca, EPE, Amadora

1500-650

Hospital da Luz, SA, Lisbon

1649-035

Centro Hospitalar de Lisboa Norte, EPE - Hospital de Santa Maria, Lisbon

2560-280

Campus Neurologico Senior, Torres Vedras

08035

Hospital Universitari Vall d Hebron, Barcelona

08907

Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat

G51 4TF

Queen Elizabeth University Hospital, Glasgow

HU3 2JZ

Hull Royal Infirmary, Hull

L9 7LJ

The Walton Centre NHS Foundation Trust, Liverpool

SE5 9RS

Kings College London, London

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

OX3 9DU

John Radcliffe Hospital, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY