78
Participants
Start Date
June 17, 2019
Primary Completion Date
August 24, 2021
Study Completion Date
August 24, 2021
R21 Matrix-M vaccination
Three dose vaccination of 2μg, 10μg or 50μg of R21 and 50ug Matrix-M delivered intramuscularly
R21 Matrix-M vaccination and CHMI
Three dose vaccination of 2μg, 10μg or 50μg of R21 and 50ug Matrix-M delivered intramuscularly. Volunteers then have the option to be challenged with malaria by mosquito bite
R21 Matrix-M vaccination booster
Optional R21 Matrix-M vaccination booster following a three dose vaccination schedule
Guy's and St Thomas' NHS Foundation Trust, London
Imperial College Healthcare NHS Trust, London
CCVTM, University of Oxford, Churchill Hospital, Oxford
University Hospital Southampton NHS Foundation Trust, Southampton
University of Oxford
OTHER