Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery

PHASE4RecruitingINTERVENTIONAL
Enrollment

2,270

Participants

Timeline

Start Date

June 14, 2019

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2028

Conditions
StrokeAtrial Fibrillation
Interventions
DRUG

Non-vitamin K oral anticoagulant (NOAC)

Participants randomized to the intervention arm will be prescribed one of the following NOACs for the duration of follow-up: edoxaban 60 mg daily (dose reduction to 30 mg, if applicable), apixaban 5 mg twice daily (dose reduction to 2.5 mg, if applicable), dabigatran 110 mg twice daily, or rivaroxaban 20 mg daily (dose reduction to 15 mg, if applicable). The choice of NOAC will be left up to the participant's prescribing physician.

Trial Locations (105)

1186

RECRUITING

Ziekenhuis Amstelland, Amstelveen

1815

RECRUITING

Noordwest Ziekenhuisgroep, Alkmaar

2000

RECRUITING

Instituto de Investigaciones Clinicas Rosario, Rosario

2050

RECRUITING

Royal Prince Alfred Hospital, Camperdown

2139

RECRUITING

Concord Repatriation General Hospital, Concord

2145

RECRUITING

Westmead Hospital, Westmead

2170

NOT_YET_RECRUITING

Liverpool Hospital, Liverpool

2200

RECRUITING

Bankstown Hospital, Bankstown

2305

RECRUITING

John Hunter Hospital, Newcastle

2605

RECRUITING

Canberra Hospital, Garran

3045

RECRUITING

Franciscus Gasthuis, Rotterdam

3083

RECRUITING

Ikazia Hospital, Rotterdam

3128

RECRUITING

Box Hill Hospital, Box Hill

3677

RECRUITING

Northeast Health Wangaratta, Wangaratta

4000

RECRUITING

Centro Integral de Arritmias de Tucuman (CIAT), San Miguel de Tucumán

4020

RECRUITING

Redcliffe Hospital, Redcliffe

4029

NOT_YET_RECRUITING

Royal Brisbane and Women's Hospital, Herston

4031

RECRUITING

University Hospital Basel, Basel

4575

RECRUITING

Sunshine Coast Hospital and Health Service, Birtinya

5000

NOT_YET_RECRUITING

Royal Adelaide Hospital, Adelaide

RECRUITING

Odense University Hospital, Odense

5022

RECRUITING

ETZ Tilburg, Tilburg

5223

RECRUITING

Jeroen Bosch Hospital, 's-Hertogenbosch

6000

RECRUITING

Royal Perth Hospital, Perth

6700

RECRUITING

Hospital South West Jutland - University Hospital of Southern Denmark, Esbjerg

6716

RECRUITING

Hospital Gelderse Vallei, Ede

6815

RECRUITING

Rijnstate Hospital, Arnhem

7416

RECRUITING

Deventer Ziekenhuis, Deventer

7540

RECRUITING

Clinica Coronel Suarez, Coronel Suárez

7609

RECRUITING

ZiekenhuisGroepTwente (ZGT), Almelo

8200

RECRUITING

Aarhus University Hospital, Aarhus

8400

RECRUITING

Kantonsspital Winterthur, Winterthur

9000

RECRUITING

Kantonsspital St. Gallen, Sankt Gallen

9728

RECRUITING

Martini Hospital, Groningen

13620

RECRUITING

Seoul National University Bundang Hospital, Seoul

15121

RECRUITING

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria

18257

RECRUITING

Karolinska Institutet Danderyd Hospital, Danderyd

20122

RECRUITING

Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan

20162

RECRUITING

ASST Grande Ospedale Metropolitano Niguarda, Milan

20520

RECRUITING

Southwest Finland Wellbeing County (VARHA), Turku

25000

RECRUITING

Rehman Medical Institute, Peshawar

28034

RECRUITING

University Hospital Ramon y Cajal, Madrid

29121

RECRUITING

Piacenza Ospedale, Piacenza

31008

RECRUITING

Hospital Universitario de Navarra, Pamplona

44700

RECRUITING

B and B Hospital, Lalitpur

56700

RECRUITING

Nobel Medical College Teaching Hospital, Biratnagar

RECRUITING

B.P. Koirala Institute of Health Sciences, Koshi

74000

RECRUITING

Aga Khan University, Karachi

77030

RECRUITING

Mcgovern Medical School at University of Texas, Houston

90048

RECRUITING

Cedars-Sinai Medical Center, Los Angeles

90146

RECRUITING

La Maddalena, Palermo

380060

NOT_YET_RECRUITING

Marengo CIMS Hospital, Ahmedabad

411057

NOT_YET_RECRUITING

Ruby Hall Clinic, Pune

560010

RECRUITING

NU Hospitals, Bangalore

560034

RECRUITING

St. John's Medical College Hospital, Bangalore

605006

RECRUITING

JIPMER, Puducherry

680555

RECRUITING

Amala Institute of Medical Sciences, Thrissur

NOT_YET_RECRUITING

Amala Institute, Thrissur

688005

NOT_YET_RECRUITING

Govt. T.D. Medical College, Alappuzha

695011

RECRUITING

Trivandrum Medical, Thiruvananthapuram

781031

NOT_YET_RECRUITING

GNRC Medical, North Guwāhāti

S2000

RECRUITING

Instituto Cardiovascular de Rosario, Rosario

B6620

RECRUITING

Hospital Municipal Chivilcoy, Chivilcoy

T4000

RECRUITING

Sanatorio Cisma, San Miguel de Tucumán

S2000GAP

NOT_YET_RECRUITING

Hospital Privado de Rosario, Santa Fe

05403-900

RECRUITING

Instituto do Coração do Hospital das Clínicas da FMUSP, Cerqueira César

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre, Porto Alegre

T2N 2T9

RECRUITING

Foothills Hospital, Calgary

T6G 2B7

RECRUITING

University of Alberta Hospital, Edmonton

T1A 4H6

RECRUITING

Medicine Hat Regional Hospital, Medicine Hat

V1C 3H9

NOT_YET_RECRUITING

East Kootenay Regional Hospital, Cranbrook

V3V 1Z2

RECRUITING

Fraser Health Authority, Surrey

V5Z 1N1

RECRUITING

Vancouver General Hospital, Vancouver

R3A 1R9

RECRUITING

Health Sciences Centre Winnipeg, Winnipeg

E1C 2Z3

NOT_YET_RECRUITING

Dr.-Georges-L.-Dumont University Hospital Centre, Moncton

B3H 3A6

RECRUITING

Halifax Infirmary, Halifax

B1M 1A2

RECRUITING

Cape Breton University, Sydney

N1R 6V6

NOT_YET_RECRUITING

Cambridge Cardiac Care Centre, Cambridge

L8L 2X2

RECRUITING

Hamilton General Hospital, Hamilton

L8N 4A6

RECRUITING

St. Joseph's Healthcare Hamilton, Hamilton

L8V 1C3

RECRUITING

Juravinski Hospital, Hamilton

K7L 2V7

RECRUITING

Kingston General Hospital, Kingston

N6A 5A5

RECRUITING

London Health Sciences Centre - University Hospital, London

K1H 8L6

RECRUITING

The Ottawa Hospital General Campus, Ottawa

L2S 0A9

RECRUITING

Niagara Health System - St. Catharine's Site, St. Catharines

L6A 4Z3

RECRUITING

Cortelluci Vaughan Hospital, Vaughan

H2X 3E4

RECRUITING

Centre Hospitalier de l'Université de Montréal, Montreal

G1R 2J6

NOT_YET_RECRUITING

CHU de Quebec Universite Laval, Québec

J1H 5H3

RECRUITING

Hôpital Fleurimont du Centre hospitalier universitaire de Sherbrooke, Sherbrooke

S4P 0W5

RECRUITING

Regina General Hospital, Regina

S7N 0W8

RECRUITING

Royal University Hospital, Saskatoon

04103

RECRUITING

Universitatsklinikum Leipzig, Leipzig

4818 CK

RECRUITING

Amphia Ziekenhuis Breda, Breda

04412

RECRUITING

Maroof International Hospital, Islamabad

Unknown

RECRUITING

Shifa International Hospital, Islamabad

RECRUITING

Dow Medical University, Karachi

02841

RECRUITING

Korea Univesrity Anam Hospital, Seoul

03080

RECRUITING

Seoul National University Hospital, Seoul

08003

NOT_YET_RECRUITING

Hospital de Mar, Barcelona

08014

NOT_YET_RECRUITING

Vall d'Hebron Hospital, Barcelona

08025

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

08221

RECRUITING

Hospital Mutua de Terrassa, Barcelona

751 85

RECRUITING

Uppsala University, Uppsala

L14 3PE

RECRUITING

Liverpool Heart and Chest Hospital, Liverpool

SS0 0RY

RECRUITING

Southend Hospital, Westcliff-on-Sea

All Listed Sponsors
collaborator

Hamilton Health Sciences Corporation

OTHER

lead

Population Health Research Institute

OTHER

NCT03968393 - Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery | Biotech Hunter | Biotech Hunter