40
Participants
Start Date
February 3, 2017
Primary Completion Date
December 5, 2018
Study Completion Date
December 1, 2020
Group I (Standard DL-PDT)
Daylight photodynamic therapy with photosensitizer (MAL - Metvix, Galderma ®)
Group II (DL-PDT with microneedles)
Daylight photodynamic therapy with photosensitizer (MAL - Metvix, Galderma ®) and Microneedles - motorized pen with a tip of 17 grouped needles with 0,5mm (Dermapen Beauty®- Korea) as a techniques of transepidermal drug delivery (TED)
Group III (DL-PDT with CO2 laser)
Daylight photodynamic therapy with photosensitizer (MAL - Metvix, Galderma ®) and Ablative Fractional Laser (AFXL), CO2 laser, roller-type ferrule, composed of one row with seven fractionating pins (7x1), 60 W, 15 mJ/pixel, 125μm/pixel, 2 mm spacing between ablation zones, density \<1% (Pixel Alma Lasers ®) was applied, single-pass
Group IV (DL-PDT with microdermabrasion)
Daylight photodynamic therapy with photosensitizer (MAL - Metvix, Galderma ®) and Microdermabrasion - aluminum oxide crystal (Pan Eletronic®) as a techniques of transepidermal drug delivery (TED)
Hospital Universitário Antonio Pedro - Universidade Federal Fluminense, Niterói
Universidade Federal Fluminense
OTHER