NCT03961841View on ClinicalTrials.gov

Perioperative Combination Chemotherapy Versus Chemoradiation for Locally Advanced EGJ Adenocarcinoma

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

900

Participants

Timeline

Start Date

June 30, 2020

Primary Completion Date

August 31, 2024

Study Completion Date

August 31, 2029

Conditions
Esophagogastric Junction DisorderNeoplasms
Interventions
RADIATION

chemoradiation with weekly 5Fu and oxaliplatin

5Fu 225 mg/m2 IV daily continuous infusion；oxaliplatin 40 mg/m2/week

DRUG

Perioperative mFLOT

Perioperative docetaxel 50mg/m2；oxaliplatin 85 mg/m2; 5Fu 2.4g/m2 civ 48 hours; repeated every 2 weeks; total of 8 cycles

DRUG

Perioperative FOLFOX

Perioperative oxaliplatin 85 mg/m2; 5Fu 2.8g/m2 civ 48 hours; repeated every 2 weeks; total of 12 cycles

All Listed Sponsors
lead

Sixth Affiliated Hospital, Sun Yat-sen University

OTHER