50
Participants
Start Date
October 1, 2017
Primary Completion Date
December 31, 2018
Study Completion Date
March 1, 2019
Ledipasvir 90 MG / Sofosbuvir 400 MG [Harvoni]
The fifty (50) thalassemic children infected with HCV received the new direct-acting antiviral therapy in the form of Ledipasvir (90 mg)/Sofosbuvir (400 mg); (Harvoni) as a single oral tablet /day for 12 weeks Follow up of these patients was performed for 24 weeks. Re-evaluation of these children after 24 weeks from initiation of Ledipasvir/Sofosbuvir treatment was performed by repeating clinical assessment, Fibroscan of liver , laboratory investigations including quantitative HCV RNA by PCR and serum hyaluronic acid measurement.
Pediatric Hematology Unit, Faculty of Medicine, Tanta University, Tanta
Tanta University
OTHER