Stereotactic Body Radiation Therapy (SBRT) vs Trans-Arterial Chemoembolization (TACE) as Bridge to Transplant

PHASE3TerminatedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

March 1, 2020

Primary Completion Date

February 28, 2024

Study Completion Date

February 28, 2024

Conditions
Hepatocellular CarcinomaHCC
Interventions
RADIATION

Stereotactic Body Radiation Therapy (SBRT)

SBRT will be delivered in five total fractions, with at a minimum of one day between any two treatments. The entire treatment must be delivered within 15 total days.

PROCEDURE

Trans-Arterial Chemoembolization (TACE)

First day will be administered and a second TACE will be administered after 4 weeks and subsequently if imaging is showing disease progression. Following each TACE procedure all patients will remain in hospital for observation

DRUG

Doxorubin

This procedure will be completed with 2 vials of drug eluting beads each loaded with 50 mg of Doxorubin.

Trial Locations (5)

43202

The Ohio State University Comprehensive Cancer Center, Columbus

55905

Mayo Clinic, Rochester

68198

University of Nebraska Medical Center, Omaha

01805

Lahey Hospital & Medical Center, Burlington

M5G 1X6

Princess Margaret Hospital, UHN, Toronto

All Listed Sponsors
collaborator

Varian Medical Systems

INDUSTRY

collaborator

Merit Medical Systems, Inc.

INDUSTRY

lead

Lahey Clinic

OTHER