Clinical Trial Evaluating FOLFIRI + Durvalumab vs FOLFIRI + Durvalumab and Tremelimumab in Second-line Treatment of Patients With Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

107

Participants

Timeline

Start Date

July 17, 2019

Primary Completion Date

March 15, 2022

Study Completion Date

November 27, 2024

Conditions
Gastric AdenocarcinomaGastric Cancer
Interventions
DRUG

Durvalumab

1500 mg by 1-hour IV infusion - Every 4 weeks

DRUG

Tremelimumab

75 mg by 1-hour IV infusion - Every 4 weeks

DRUG

FOLFIRI Protocol

"* Irinotecan: 180 mg/m² by 2-hour IV infusion,~* Folinic acid: 400 mg/m² (or 200 mg/m² if Elvorine) by 2-hours IV infusion,~* 5-FU bolus: 400 mg/m² by 10-minutes IV bolus,~* Continuous 5-FU: 2400 mg/m² by 46-hour IV infusion"

Trial Locations (35)

51092

Chu - Hôpital Robert Debré, Reims

75475

Chu - Aphp - Hôpital Saint Louis, Paris

Unknown

Ch - Centre Hospitalier, Abbeville

Ch - Hôpital Claude Bernard, Albi

Chu - Hôpital Sud, Amiens

Privé - Clinique de L'Europe, Amiens

Chu - Hôpital Hôtel Dieu, Angers

Privé - Hôpital Privé D'Antony, Antony

Ch - Hôpital Victor Dupouy, Argenteuil

Ch - Hôpital Henri Duffaut, Avignon

Privé - Clinique Sainte Catherine, Avignon

Ch - Hôpital Côte Basque, Bayonne

Privé - Clinique Capio Belharra, Bayonne

Chu - Hôpital Jean Minjoz, Besançon

Ch - Hôpital Germon Et Gauthier, Béthune

Ch - Centre Hospitalier de Bézier, Béziers

Privé - Clinique Tivoli, Bordeaux

Privé - Polyclinique Bordeaux Nord, Bordeaux

Ch - Hôpital Duchenne, Boulogne-sur-Mer

Chu - Hôpital Morvan, Brest

Chu - Hôpital Côte de Nacre, Caen

Privé - Clinique Maurice Tubiana, Caen

Privé - Infirmerie Protestante, Caluire-et-Cuire

Ch - Centre Hospitalier de Carcassonne, Carcassonne

Privé - Pôle Santé Léonard de Vinci, Chambray-lès-Tours

Privé - Hôpital Privé Paul D'Egine, Champigny-sur-Marne

Ch - Chp Du Cotentin, Cherbourg

Ch - Centre Hospitalier de Cholet, Cholet

Chu - Hôpital Estaing, Clermont-Ferrand

Ch - Hopitaux Civils de Colmar, Colmar

Privé - Clinique Saint Côme, Compiègne

Privé - Clinique Des Cèdres, Cornebarrieu

Prive - Clinique Jean Mermoz, Lyon

Prive - Institut Montsouris, Paris

Chu - Hôpital La Miletrie, Poitiers

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Federation Francophone de Cancerologie Digestive

OTHER