T-cells Expressing an Anti-SLAMF7 CAR for Treating Multiple Myeloma

PHASE1CompletedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

June 13, 2019

Primary Completion Date

October 13, 2020

Study Completion Date

January 19, 2021

Conditions
Myeloma-MultipleMyeloma, Plasma-Cell
Interventions
DRUG

Cyclophosphamide

300 mg/m\^2 intravenous (IV) over 30 minutes on days -5, -4, and -3

DRUG

Fludarabine

30 mg/m\^2 intravenous (IV) over 30 minutes immediately following the cyclophosphamide on day -5, -4, and -3

DRUG

Rimiducid

0.4 mg/kg of Rimiducid intravenous (IV) over 2 hours. (A maximum of 2 doses separated by at least 48 hours) Note: Rimiducid may be administered as needed based on the patient condition at the discretion of the Principal Investigator.

BIOLOGICAL

Anti-Signaling lymphocytic activation molecule F7 (SLAMF7) chimeric antigen receptor (CAR) T cells

0.3x10\^6- 12.0x10\^6 CAR+ T cells per kg of recipient bodyweight one-time dose on day 0

Trial Locations (1)

20892

National Institutes of Health Clinical Center, Bethesda

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT03958656 - T-cells Expressing an Anti-SLAMF7 CAR for Treating Multiple Myeloma | Biotech Hunter | Biotech Hunter