Zephyrus I: Evaluation of Efficacy and Safety of Pamrevlumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)

PHASE3TerminatedINTERVENTIONAL
Enrollment

393

Participants

Timeline

Start Date

June 18, 2019

Primary Completion Date

March 20, 2023

Study Completion Date

August 28, 2023

Conditions
Idiopathic Pulmonary Fibrosis
Interventions
DRUG

Pamrevlumab

Pamrevlumab will be administered per dose and schedule specified in the arm description.

DRUG

Placebo

Placebo matching to pamrevlumab will be administered per schedule specified in the arm description.

Trial Locations (125)

1426

Fundacion Respirar - Centro Médico Dra. De Salvo, Ciudad Autonoma de Buenos Aires (caba)

1900

Centro Platense en Investigaciones Respiratorias, La Plata

2050

Royal Prince Alfred Hospital, Sydney

2145

Westmead Hospital, Westmead

2841

Korea University Anam Hospital, Seoul

3004

The Alfred Hospital, Melbourne

3080

Seoul National University Hospital, Seoul

3128

Box Hill Hospital, Box Hill

4101

Mater Health Services Adult Hospital, South Brisbane

5000

Royal Adelaide Hospital, Adelaide

5505

Asan Medical Center, Seoul

6351

Samsung Medical Centerx, Seoul

10010

Affiliated Hospital of Inner Mongolia Medical University, Hohhot

10020

People's Hospital of Inner Mongolia Autonomous Region, Hohhot

12208

Albany Medical College, Albany

13088

Pulmonary Health Physicians, PC, Liverpool

13620

Seoul National University Bundang Hospital, Seongnam-si

14579

Soonchunhyang University Bucheon Hospital, Bucheon-si

14647

The Catholic University of Korea, Bucheon St. Mary's Hospital, Bucheon-si

16499

Ajou University Hospital, Suwon

17033

Penn State Milton S. Hershey Medical Center, Hershey

19140

Temple University, Philadelphia

20007

Medstar Georgetown University Hospital, Washington D.C.

21201

University of Maryland, Baltimore, Baltimore

21565

Gachon University Gil Medical Center, Incheon

23561

Taipei Medical University - Shuang-Ho Hospital, Ministry of Health and Welfare, Taipei

27403

Pulmonix, LLC, Greensboro

29406

Lowcountry Lung and Critical Care, PA, Charleston

29425

Medical University of South Carolina, Charleston

30106

Piedmont Healthcare, Inc., Austell

30322

Emory University, Atlanta

32209

University of Florida Health, Jacksonville, Jacksonville

32224

Mayo Clinic, Jacksonville

32610

University of Florida Pulmonary, Critical Care & Sleep Medicine Division, Gainesville

33606

University of South Florida, Tampa

33765

St. Francis Medical Center, Clearwater

34741

Pulmonary Disease Specialist, PA d/b/a, PDS Research, Kissimmee

35294

University of Alabama at Birmingham Hospital, Birmingham

37075

Tennessee Comprehensive Lung and Sleep Center, Hendersonville

37204

Vanderbilt University Medical Center, Nashville

40705

Taichung Veterans General Hospital, Taichung

43221

Ohio State University, Columbus

45267

University of Cincinnati, Cincinnati

46202

Indiana University School of Medicine, Indianapolis

47392

Inje University Busan Paik Hospital, Busan

48109

University of Michigan, Ann Arbor

48202

Henry Ford Hospital, Detroit

49546

Spectrum Health, Grand Rapids

53226

Medical College of Wisconsin, Milwaukee

55455

University of Minnesota, Minneapolis

60153

Loyola University of Chicago, Maywood

60612

Northwestern University, Chicago

63017

The Lung Research Center, LLC, Chesterfield

66160

The University of Kansas Medical Center, Kansas City

72032

J&L Research, Conway

73112

INTEGRIS Baptist Medical Center, Oklahoma City

75246

Baylor Scott and White Research Institute, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

77030

Baylor College of Medicine, Houston

University of Texas - Houston, Houston

77380

Renovatio Clinical, The Woodlands

77429

Houston Pulmonary Sleep, Allergy and Asthma Associates, Cypress

78229

UT Health San Antonio, San Antonio

80045

University of Colorado Denver, Aurora

80207

National Jewish Health, Denver

84108

University of Utah Health, Salt Lake City

85006

Banner University Medical Center - Phoenix, Phoenix

85013

Norton Thoracic Institute, Phoenix

85032

Pulmonary Associates, PA - Research, Phoenix

85724

University of Arizona, Tucson

90095

David Geffen School of Medicine at UCLA, Los Angeles

92103

University of California San Diego, San Diego

92354

Loma Linda University Health, Loma Linda

94305

Stanford University Medical Center, Stanford

95817

UC Davis Medical Center, Sacramento

97210

Legacy Research Institute, Portland

97220

The Oregon Clinic, Portland

98195

University of Washington, Seattle

100020

BeiJing Chao-Yang Hospital,Capital medical university, Beijing

100029

China-Japan friendship hospital, Beijing

100730

Peking Union Medical College Hospital, Beijing

110001

The First Hospital of China Medical University, Shenyang

115419

Euromedservice, Clinical and Diagnostic Center, Moscow

116001

The second hospital of Dalian medical university, Dalian

129110

MONIKI, Moscow

191180

Vvedenskaya hospital, Saint Petersburg

194354

"Medical Center Reavita Med SPb", Saint Petersburg

197022

FSBEI HE First Pavlov Medical University, Saint Petersburg

200025

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

230000

Second Affiliated Hospital of Anhui Medical University, Hefei

300052

General Hospital of Tianjin Medical University, Tianjin

310006

Hangzhou First People's Hospital, Hangzhou

410011

The Second Xiangya Hospital of Central South University, Changsha

420029

Kazan State Medical University based on Republican Clinical Hospital, Kazan'

430022

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan

Union Hospital,Tongji Medical College of Huazhong University of Science and Technology, Wuhan

450000

Henan Provincial People's Hospital, Zhengzhou

450003

Henan Provincial chest hospital, Zhengzhou

454106

Regional Clinical Hospital #3, Chelyabinsk

510000

Nanfang Hospital of Southern Medical University, Guangzhou

510120

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

518020

Shenzhen people's hospital, Shenzhen

620109

"Medical Association NEW HOSPITAL", Yekaterinburg

644112

City Clinical Hospital #1 n.a. A.N. Kabanov, Omsk

650000

Clinical Hospital #3, Kemerovo

710004

The Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an

750004

General Hospital of Ningxia Medical University, Yinchuan

3465586

Centro Investigacion del Maule CIM, Talca

6100141

Huaxi Hospital of Sichuan University., Chengdu

7500691

Instituto Nacional del Torax, Santiago

7500692

CIMER, Santiago

7750495

M y F estudios clinicos, Santiago

06510

Yale University School of Medicine, New Haven

03756

Dartmouth-Hitchcock Medical Center, Lebanon

02903

Rhode Island Hospital, Providence

05405

The University of Vermont, Burlington

C1027AAP

Centro de Investigacion Metabolica 'CINME', Ciudad Autonoma de Buenos Aires

C1425FVH

Consultorios Medicos. Organización del Buen Ayre. SRL, Ciudad Autonoma de Buenos Aires

B1602DQD

Centro Medico de Enfermedades Respiratorias, Florida

B7602DCK

Instituto ave Pulmo Fundacion enfisema, Mar del Plata

M5501GCA

Respira Salud Clinica Integral, Godoy Cruz

M5500CCG

INSARES, Mendoza

T4000IAR

Investigaciones en Patologias Respiratorias, San Miguel de Tucumán

Unknown

Queen Mary Hospital, Central

Tuen Mun Hospital, Hong Kong

Sponsors

Lead Sponsor

All Listed Sponsors
lead

FibroGen

INDUSTRY