IPACK Study in Total Knee Arthroplasty Patients

PHASE4CompletedINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

October 24, 2019

Primary Completion Date

December 2, 2020

Study Completion Date

March 31, 2021

Conditions
Knee Replacement Arthroplasty
Interventions
DRUG

Standard of Care (ACB, SA, peri-op pain management)

"INTERVENTION BEFORE SURGERY~Adductor Canal Block will be done using Adductor canal catheter (tube in the thigh) + injection of freezing medication~INTERVENTION DURING SURGERY~IV propofol for sedation~INTERVENTION AFTER SURGERY~Injection of salty water through the tube in the thigh x 2"

DRUG

IPACK and multi-modal analgesic regimen

"INTERVENTION BEFORE SURGERY~1. Adductor Canal Block will be done using Adductor canal catheter (tube in the thigh) + injection of freezing medication~2. iPACK block ( infiltration between Popliteal Artery and posterior Capsule of the Knee) - injection of freezing medication in the back of the knee~INTERVENTION DURING SURGERY~1. IV dexmedetomidine~2. IV ketamine Both for sedation~INTERVENTION AFTER SURGERY~1. injection of freezing medication through the tube in the thigh x 2~2. IV dexamethasone 8 mg 1 day after surgery"

PROCEDURE

Periarticular Local Anesthetic Infiltration

INTERVENTION DURING SURGERY

DRUG

IV Dexamethasone 8mg at the end of surgery as standard of care

INTERVENTION DURING SURGERY

Trial Locations (1)

M5T2S8

Toronto Western Hopspital, Toronto

All Listed Sponsors
lead

University Health Network, Toronto

OTHER

NCT03954379 - IPACK Study in Total Knee Arthroplasty Patients | Biotech Hunter | Biotech Hunter