Gene Therapy Clinical Study in Adult PKU

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

June 10, 2019

Primary Completion Date

January 10, 2023

Study Completion Date

August 1, 2023

Conditions
PhenylketonuriasPAH Deficiency
Interventions
GENETIC

HMI-102

HMI-102 is an AAVHSC15 vector containing a functional copy of the human PAH gene

GENETIC

HMI-102

"Control subjects will generally have the same assessments as treated subjects.~Control subjects will undergo pre-baseline procedures to confirm that they are eligible to receive treatment with HMI-102. Once eligible control subjects are dosed with HMI-102, they will initiate the same post-dose procedures as subjects who received HMI-102."

Trial Locations (13)

10029

Icahn School of Medicine at Mount Sinai, New York

15224

UPMC Children's Hospital of Pittsburgh, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

27599

The University of North Carolina At Chapel Hill, Chapel Hill

30322

Emory University Hospital, Atlanta

33606

University of South Florida, Tampa

43205

Nationwide Children's Hospital, Columbus

60611

Lurie Children's Hospital of Chicago, Chicago

75235

University of Texas Southwestern Medical Center, Dallas

84108

University of Utah, Salt Lake City

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

92868

Children's Hospital of Orange County, Orange

02115

Boston Children's Hospital, Boston

Sponsors
All Listed Sponsors
lead

Homology Medicines, Inc

INDUSTRY