Flublok or Fluzone With Advax-CpG55.2 or AF03

PHASE1CompletedINTERVENTIONAL
Enrollment

241

Participants

Timeline

Start Date

June 10, 2019

Primary Completion Date

September 18, 2020

Study Completion Date

September 18, 2020

Conditions
InfluenzaInfluenza Immunisation
Interventions
DRUG

AF03

A squalene-in-PBS emulsion stabilized by nonionic surfactants, sorbitan oleate and macrogol cetostearyl ether

BIOLOGICAL

Delta Inulin-CpG55.2

A combination adjuvant supplied as two separate components, Delta Inulin (Sypharma Pty Ltd.) and CpG55.2 (Nikko Denka Avecia and Sypharma Pty Ltd)

BIOLOGICAL

Influenza Virus Quadrivalent Inactivated Vaccine

2018/2019 Fluzone QIV and 2019/2020 Fluzone QIV vaccines will be given with 90 days interval

BIOLOGICAL

Quadrivalent Recombinant Seasonal Influenza Vaccine

2018/2019 Flublok QIV and 2019/2020 Flublok QIV vaccines will be given with 90 days interval

Trial Locations (8)

27704

Duke Vaccine and Trials Unit, Durham

30322-1014

Emory University School of Medicine, Atlanta

52242-2600

University of Iowa - Vaccine Research and Education Unit, Iowa City

21201-1509

University of Maryland Baltimore - School of Medicine - Medicine, Baltimore

63104-1015

Saint Louis University Center for Vaccine Development, St Louis

45229-3039

Cincinnati Children's Hospital Medical Center Vaccine Research Center, Cincinnati

37232-2573

Vanderbilt University - Pediatric - Vanderbilt Vaccine Research Center, Nashville

77030-3411

Baylor College of Medicine, Houston

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT03945825 - Flublok or Fluzone With Advax-CpG55.2 or AF03 | Biotech Hunter | Biotech Hunter