A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

September 19, 2019

Primary Completion Date

May 11, 2023

Study Completion Date

October 31, 2025

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Tepotinib

Participants were administered with Tepotinib orally once daily at a dose of 500 mg.

DRUG

Osimertinib

Participants received Osimertinib at a dose of 80 mg orally once daily.

Trial Locations (179)

10016

NYU Langone Clinical Cancer Center - NYU Langone Medical Center, New York

NYU Langone Clinical Cancer Center - NYU Langone Medical Cente, New York

10021

Weill Cornell Medical College - Gastroenterology, New York

17325

Gettysburg Cancer Center, Gettysburg

20817

The Center for Cancer & Blood Disorders - Maryland, Bethesda

21237

Medstar Franklin Square Clinical Research Center, Baltimore

21702

Frederick Health- James M Stockman Cancer Institute, Frederick

22408

Hematology Oncology Associates of Fredericksburg, Fredericksburg

27534

Southeastern Medical Oncology Center, Goldsboro

30607

University Cancer and Blood Center, Athens

32256

Cancer Specialists of North Florida, Jacksonville

33021

Memorial Healthcare System, Hollywood

33308

Holy Cross, Fort Lauderdale

34474

Ocala Oncology, Ocala

37201

Tennessee Oncology, Nashville

38120

Baptist Cancer Center, Memphis

40202

Norton Cancer Institute, Louisville

43214

OhioHealth, Columbus

44106

University Hospitals Seidman, Cleveland

46250

Community Health Network, Indianapolis

46601

Beacon Health, South Bend

46845

Fort Wayne Medical Oncology and Hematology, Fort Wayne

48912

Sparrow Hospital Herbert - Herman Cancer Center, Lansing

57104

Sanford Health, Sioux Falls

57108

Avera Cancer Institute, Sioux Falls

60637

University of Chicago Medical Center, Chicago

63044

St. Louis Cancer Care, LLP, Bridgeton

64507

Mosaic Life Care, Saint Joseph

65613

Central Care Cancer Center (CCCC), Bolivar

70433

Pontchartrain, Hammond

74146

Oklahoma Cancer Specialists and Research Institute, Tulsa

75230

Mary Crowley Cancer Research, Dallas

77030

University of Texas MD Anderson Cancer Center - Unit 432 Thoracic Head and Neck Medical Oncology, Houston

84106

Utah Cancer Specialists, Salt Lake City

84405

Community Cancer Trials of Utah, Ogden

85364

Yuma Regional Medical Center, Yuma

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90806

Memorial Care, Long Beach

92708

Compassionate Care Research Group Inc - Edinger Medical Group, Inc., Fountain Valley

92801

Innovative Clinical Research Institute, Whittier

93030

Ventura County Hematology Oncology Specialists, Oxnard

96813

Hawaii Cancer Care, Honolulu

97301

Oregon Oncology Specialists, Salem

98405

Northwest Medical Specialties, Tacoma

06360

Eastern Connecticut Hematology & Oncology Associates, Norwich

02118

Boston Medical Center - Dept. Hematology/Oncology, Boston

02719

Southcoast Center for Cancer Care, Fairhaven

07109

New Jersey Cancer Care and Blood Disorders, Belleville

07932

Summit Medical Group, Florham Park

Unknown

UZ Antwerpen - Department of Oncology, Edegem

UZ Leuven, Gasthuisberg

AZ Delta, Roeselare

Beijing Hospital, Beijing

Peking Union Medical College Hospital, Beijing

Peking University Cancer Hospital, Beijing

Jilin Cancer Hospital - Oncology, Changchun

The First Hospital of Jilin University, Changchun

Hunan Cancer Hospital, Changsha

West China Hospital, Sichuan University, Chengdu

Fujian Cancer Hospital, Fuzhou

Guangdong General Hospital, Guangzhou

The First Affiliated Hospital, Zhejiang University, Hangzhou

Zhejiang Cancer Hospital, Hangzhou

Affiliated Tumor Hospital of Harbin Medical University, Harbin

Anhui Chest Hospital, Hefei

Linyi Tumor Hospital, Linyi

Jiangsu Province Hospital, Nanjing

Shanghai Cancer Hospital, Fudan University, Shanghai

Shanghai Chest Hospital, Shanghai

Liaoning Cancer Hospital & Institute, Shenyang

The Affiliated Cancer Hospital of Xinjiang Medical university, Ürümqi

Hubei Cancer Hospital, Wuhan

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

Centre Francois Baclesse - Service d'Oncologie Medicale, Caen

Centre Hospitalier Intercommunal de Créteil - Service de Pneumologie, Créteil

CHU Limoges - Hôpital Dupuytren - Unite d'Oncologie Thoracique et Cutanée, Limoges

Centre Léon Bérard, Lyon

Hopital Albert Calmette - CHU Lille - service de pneumologie et immuno allergologie, Nord

Hopital Tenon - service pneumologie, Paris

Hospital Cochin Service, Service de Pneumologie et Mucoviscidose, Paris

Groupe Hospitalier Sud - Hôpital Haut-Lévêque - Maison du Ha, Pessac

CHU de Toulouse - Hôpital Larrey - Service de Pneumologie et Oncologie Pneumologique, Toulouse

Universitaetsklinikum Koeln - Innere Medizin I, Onkologie, Haematologie, Cologne

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

Asklepios Fachkliniken Muenchen-Gauting - Abteilung internistische Onkologie, Gauting

Universitaetsklinikum Giessen und Marburg GmbH Standort Giessen, Giessen

Universitaetsmedizin Goettingen, Göttingen

Evangelisches Krankenhaus Hamm gGmbH, Hamm

Evangelisches Krankenhaus Hamm GmbH, Hamm

Thoraxklinik-Heidelberg gGmbH, Heidelberg

Staedtisches Krankenhaus Kiel, Kiel

POIS Leipzig GbR, Leipzig

Universitaetsklinikum Schleswig-Holstein - Campus Luebeck, Lübeck

Pius-Hospital Oldenburg - Klinik f. Haematologie und Onkologie, Oldenburg

Missionsärztliche Klinik, Würzburg

Queen Elizabeth Hospital - Department of Medicine, Hong Kong

The University of Hong Kong, Hong Kong

The Chinese University of Hong Kong - Emergency Medicine, Shatin

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oncologia Medica, Lazio

IEO Istituto Europeo di Oncologia, Milan

Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo) - U.O Oncologia Medica, Monza

Ospedale Monaldi, Napoli

IOV - Istituto Oncologico Veneto IRCCS - Oncologia Medica 2, Padua

AO Ospedali Riuniti Cervello - Presidio Villa Sofia - U.O.S. di Neuroimmunologia, Palermo

Azienda Ospedaliero Universitaria Pisana - U.O. Pneumologia II, Pisa

Istituto Nazionale Tumori Regina Elena IRCCS - S.C. Oncologia Medica B, Roma

Istituto Clinico Humanitas, Rozzano

Azienda Socio Sanitaria Territoriale Sette Laghi (Presidio Ospedale di Circolo e Fondazione Macchi) - Oncologia Medica, Varese

Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma) - U.O.C. Oncologia, Verona

Hamamatsu University School of Medicine, University Hospital - Dept of Respiratory Medicine, Hamamatsu

Saitama Cancer Center, Kitaadachi-gun

Kurume University Hospital, Kurume-shi

Nagoya University Hospital - Dept of Respiratory Medicine, Nagoya

Niigata Cancer Center Hospital - Dept of Internal Medicine, Niigata

Hyogo College of Medicine Hospital - Dept of Respiratory Medicine, Nishinomiya-shi

Okayama University Hospital - Dept of Respiratory Medicine/Allergy, Okayama

Osaka City General Hospital, Osaka

Kindai University Hospital, Osakasayama-shi

NHO Yamaguchi - Ube Medical Center, Ube-shi

Kanagawa Cancer Center - Dept of Respiratory Medicine, Yokohama

Pantai Hospital Kuala Lumpur, Kuala Lumpur

University Malaya Medical Centre, Kuala Lumpur

Beacon International Specialist Centre Sdn Bhd, Kuala Selangor

Hospital Tengku Ampuan Afzan, Kuantan

Hospital Umum Sarawak, Kuching

Sunway Medical Centre, Petaling Jaya, Selangor

Hospital Pulau Pinang - Clinic Respiratory, Pulau Pinang

The Netherlands Cancer Institute, Amsterdam

Universitair Medisch Centrum Groningen - Department of Internal Medicine, Groningen

Maastricht University Medical Center - Dept of Medical Oncology, Maastricht

"SBHI Krasnoyarsk Regional Oncology Dispensary n.a. A.I. Kryzhanovsky", Krasnoyarsk

"VitaMed LLC", Moscow

"LLC Tonus", Nizniy Novgorod

"BHI of Omsk region Clinical Oncology Dispensary", Omsk

"LLC ClinicaUZI4D", Pyatigorsk

"FBI Scientific Research Institute of Oncology n. a. N. N. Petrov", Saint Petersburg

Pavlov First Saint Petersburg State Medical University - Research Institute of Pulmunology, Saint Petersburg

Icon Cancer Centre, Connexion

National Cancer Centre - Medical Oncology Pharmacy, Singapore

Tan Tock Seng Hospital - CTRU/OCS, Research, Singapore

National Cancer Center, Goyang-si

Chonnam National University Hwasun Hospital, Hwasun-gun

Seoul National University Bundang Hospital, Seongnam-si

Asan Medical Center, Seoul

Korea University Anam Hospital, Seoul

Samsung Medical Center, Seoul

Seoul National University Hospital, Seoul

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

Ulsan University Hospital, Ulsan

ICO Badalona - Hospital Germans Trias i Pujol - Servicio de Oncologia Medica, Badalona

Hospital del Mar - Servicio de Oncologia, Barcelona

Hospital Universitari Dexeus - Servicio de Oncologia Medica, Barcelona

Hospital Universitari Quiron Dexeus - Servicio de Oncologia Medica, Barcelona

Hospital Universitari Vall d'Hebron - Dept of Oncology, Barcelona

ICO l´Hospitalet - Hospital Duran i Reynals - Servicio de Oncologia, L'Hospitalet de Llobregat

Hospital Universitario Materno-Infantil de Canarias - Servicio de Oncologia, Las Palmas de Gran Canaria

Hospital Universitario HM Madrid Sanchinarro - Servicio de Oncologia, Madrid

Hospital Regional Universitario de Malaga, Málaga

Hospital Universitari Son Espases - Servicio de Oncologia Medica, Palma

Hospital Universitario Quiron Madrid - Unidad Integral de Oncologia, Pozuelo de Alarcón

Hospital Universitario Virgen Macarena - Servicio de Oncologia, Seville

Hospital Universitari i Politecnic La Fe - Servicio de Oncologia Medica, Valencia

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

China Medical University Hospital, Taichung

Taichung Veterans General Hospital, Taichung

Chi Mei Medical Center, Liou Ying, Tainan City

National Taiwan University Hospital, Taipei

Taipei Veterans General Hospital, Taipei

Tri-Service General Hospital, Taipei

Siriraj Hospital, Bangkoknoi

Songklanagarind Hospital, Hat Yai

Maharaj Nakorn Chiang Mai Hospital, Muang

King Chulalongkorn Memorial Hospital, Pathumwan

Bach Mai Hospital, Hanoi

K Hospital, Hanoi

National Lungs Hospital, Hanoi

Cho Ray Hospital, Ho Chi Minh City

HCMC Oncology Hospital, Ho Chi Minh City

Pham Ngoc Thach Hospital, Ho Chi Minh City

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

EMD Serono Research & Development Institute, Inc.

INDUSTRY

NCT03940703 - A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2) | Biotech Hunter | Biotech Hunter