Effect of Tumor Treating Fields (TTFields, 200 kHz) Concomitant With Weekly Paclitaxel for the Treatment of Recurrent Ovarian Cancer (ENGOT-ov50 / GOG-3029 / INNOVATE-3)

PHASE3CompletedINTERVENTIONAL
Enrollment

540

Participants

Timeline

Start Date

March 22, 2019

Primary Completion Date

May 18, 2023

Study Completion Date

May 18, 2023

Conditions
Ovarian Cancer
Interventions
DEVICE

NovoTTF-100L(O)

Patients receive continuous TTFields treatment using the NovoTTF-100L(O) device. TTFields treatment will consist of wearing four electrically insulated electrode arrays on the abdomen/pelvis. The treatment enables the patient to maintain regular daily routine.

DRUG

Paclitaxel

Paclitaxel 80 mg/m\^2 intravenous infusion will be administered weekly for 8 weeks and then on Days 1, 8 and 15 of each subsequent 28-day cycle.

Trial Locations (119)

1085

Semmelweis University, Budapest

1105

Amsterdam Universitair Medische centra, Amsterdam

1122

Nőgyógyászati Osztály, Országos Onkológiai Intézet, Budapest

1200

Cliniques Universitaires Saint Luc, Institut Roi Albert II, Brussels

Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Gynäkologie, Berlin

2820

Imelda Ziekenhuis Bonheiden, Bonheiden

3508

University Medical Center Utrech, Utrecht

4031

Gynecological Tumor Center, University Hospital Basel, Basel

4032

Szuleszeti és Nogyogyaszati Klinika, Debrecen

5000

CHU UCL Namur - Site Ste Elisabeth, Namur

5020

Landesfrauenklinik Salzburg, Salzburg

6000

Grand Hôpital de Charleroi, Oncologie-Hématologie, Charleroi

6500

IOSI Bellinzona, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona

7000

CHU Ambroise Paré, Mons

8020

KH der Barmherzigen Brüder Graz, Graz

8036

Univ.-Klinik für Gynäkologie und Geburtshilfe, Graz

8091

UniversitätsSpital Zürich - Klinik für Gynäkologie, Zurich

8501

Kantonsspital Frauenfeld - Frauenklinik, Frauenfeld

9000

AZ Maria Middelares, Clinical Trial Unit Medical Oncology - Integrated Cancer Center Ghent, Ghent

UZ Gent, Ghent

10126

University Saint Anna, Torino

15212

West Penn OB/GYN, Pittsburgh

15232

UPMC Cancer Center, Pittsburgh

17007

lnstitut Catala d'Oncologia, Hospital Universitario Dr. Josep Trueta, Servicio de Oncologia,, Girona

20141

Dipartimento Medicina e Chirurgia, Università Milano-Bicocca, Direttore Programma Ginecologia Oncologica, Istituto Europeo Oncologia, Milan

20902

Maryland Oncology Hematology, P.A., Silver Spring

22100

Oncology Institute, Galilee Medical Center, Nahariya

23502

Virginia Oncology Associates, Norfolk

23900

ASST Lecco - Ospedale Manzoni, Dipartimento Oncologico, Lecco

27157

Wake Forest Baptist Medical Center, Winston-Salem

28027

Clinica Universidad de Navarra en Madrid, Madrid

28033

Hospital MD Anderson Cancer Center, Madrid

28034

Hospital Universitario Ramon y Cajal, Servicio de Oncologia Médica, Madrid

28041

Hospital 12 de Octubre. Servicio Oncología Médica, Madrid

30501

Northeast Georgia Medical Center, Gainesville

32804

AdventHealth Cancer Institute, Orlando

33316

Broward Health Medical Center, Fort Lauderdale

38100

Hillel Yaffe Medical Center, Hadera

40138

Policlinico S. Orsola-Malpighi, SSD Oncologia Medica Addarii, Bologna

50309

Des Moines Oncology Research Association, Des Moines

55102

Minnesota Oncology Hematology, PA, Saint Paul

57104

Sanford Gynecologic Oncology Clinic, Sioux Falls

65199

Horst-Schmidt-Kliniken, Gynecology and Gynecologic, Oncology Department, Wiesbaden

72100

Presidio Ospedaliero Antonio Perrino - ASL Brindisi, Brindisi

75216

University of Texas Southwestern Medical Center, Dallas

75246

Texas Oncology, Dallas

75702

Texas Oncology-Tyler, Tyler

77380

Texas Oncology, The Woodlands

77598

Texas Oncology-Deke Slayton Cancer Center, Webster

78240

Texas Oncology San Antonio Medical Center, San Antonio

78503

Texas Oncology-McAllen, McAllen

78731

Texas Oncology Austin-Balcones, Austin

78745

Texas Oncology Austin-Midtown, Austin

78758

Texas Oncology Austin-North Austin, Austin

80012

Rocky Mountain Cancer Centers, Aurora

80124

Rocky Mountain Cancer Centers, Lone Tree

80130

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli

80138

Rocky Mountain Cancer Centers, Parker

80218

Rocky Mountain Cancer Centers, Denver

80220

Rocky Mountain Cancer Centers, Denver

80228

Rocky Mountain Cancer Centers, Lakewood

80260

Rocky Mountain Cancer Centers, Thornton

80303

Rocky Mountain Cancer Centers, Boulder

80501

Rocky Mountain Cancer Centers, Longmont

80907

Rocky Mountain Cancer Centers, Colorado Springs

81008

Rocky Mountain Cancer Centers, Pueblo

85016

Arizona Oncology- Biltmore Cancer Center, Phoenix

85711

Arizona Oncology, Tucson

89169

Women's Cancer Center of Nevada, Las Vegas

89502

Center of Hope at Renown Medical Center, Reno

91342

Olive View - UCLA Medical Center, Sylmar

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

94109

California Pacific Medical Center- Pacific Campus, San Francisco

97227

Northwest Cancer Specialists, PC, Portland

98405

Multicare Institute for Research and Innovation, Tacoma

5265601

Gyneco-Oncology Chaim Sheba Medical Center, Ramat Gan

9103102

Saare Zedek Medical Center - Gyneco-Oncology, Jerusalem

92093-1503

University of California, La Jolla

80045-2517

University of Colorado Denver, Aurora

80120-4413

Rocky Mountain Cancer Centers, Littleton

60612-3833

Rush University Cancer Center - Chicago and Innovation, Chicago

40202-2025

Norton Cancer Institute, Louisville

01805

Lahey Hospital & Medical Center, Burlington

63110-1010

Washington University School of Medicine in St. Louis, St Louis

68114-4108

Methodist Estabrook Cancer Center, Omaha

08103

MD Anderson Cancer Center at Cooper, Camden

07652

The Valley Hospital, Paramus

45459-447

Miami Valley Hospital South, Centerville

43210-1240

The Ohio State University Wexner Medical Center, Columbus

19001-3720

Abington Hospital- Asplundh Cancer Pavilion, Willow Grove

02905-2401

Women & Infants Hospital of Rhode Island, Providence

76104-2150

Texas Oncology-Fort Worth, Fort Worth

77030-1501

The University of Texas Medical School at Houston, Houston

77479-4308

Texas Oncology - Sugar Land, Sugar Land

24016-4962

Carilion Clinic-Gynecologic Oncology, Roanoke

Unknown

Univ.-Klinik für Gynäkologie und Geburtshilfe, Innsbruck, Innsbruck

University Hospitals Leuven, Leuven Cancer Institute, Leuven

R3E)V9

CancerCare Manitoba, Winnipeg

H2X 0A9

Centre Hospitalie, Montreal

H2L 4M1

Tom Baker Cancer Center, Calgary

H4A 3J1

McGill University Health Centre, Montreal

QC H3T 1E2

Jewish General Hospital, Montreal

370 01

Gynekologicko-porodnické oddělení - Nemocnice České Budějovice a.s., České Budějovice

779 00

Onkologická Klinika Fakultní nemocnice Olomouc, Olomouc

708 52

University Hospital Ostrava, Ostrava-Poruba

100 34

Gynekologicko-porodnická klinika, Fakultní nemocnice Královské Vinohrady, Prague

128 01

Gynekologicko-porodnická klinika 1. LF UK a VFN, Prague

01307

Universitätsklinikum Carl Gustav Carus, Dresden

60 20132

IRCCS Ospedale San Raffaele, U.O. Ginecologia-Ematologia e TMO, Milan

00168

Fondazione Policlinico Universitario Gemelli, Roma

81-519

Szpitale Pomorskie Sp. z o.o., Gdynia

30-693

Oddział Kliniczny Chirurgii Ogólnej i Onkologicznej, Szpital Św. Rafała, Krakow

20-081

Uniwersytet Medyczny w Lublinie, I Klinika Ginekologii Onkologicznej i Ginekologii, Lublin

10-228

Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA z Warmińsko-Mazurskim Centrum Onkologii w Olsztynie, Oddział Kliniczny Onkologii i Immunoonkologii z Ośrodkiem Dziennym Terapii Onkologicznej, Olsztyn

60-569

Oddział Ginekologii Onkologicznej Katedry i Kliniki Onkologii Uniwersytetu Medycznego w Poznaniu, Poznan

70-111

Samodzielny Publiczny Szpital Kliniczny Nr 2 PUM w Szczecinie, Klinika Ginekologii Operacyjnej i Onkologii Ginekologicznej Dorosłych i Dziewcząt, Szczecin

00-315

Szpital Kliniczny im. ks. Anny Mazowieckiej, Warsaw

08028

Servicio de Oncología Médica, Hospital Universitario Quirón Dexeus, Barcelona

07120

Fundació Institut d'Investigació Sanitària Illes Balears - IdISBa, Hospital Universitari Son Espases, Palma de Mallorca

All Listed Sponsors
lead

NovoCure Ltd.

INDUSTRY

NCT03940196 - Effect of Tumor Treating Fields (TTFields, 200 kHz) Concomitant With Weekly Paclitaxel for the Treatment of Recurrent Ovarian Cancer (ENGOT-ov50 / GOG-3029 / INNOVATE-3) | Biotech Hunter | Biotech Hunter