122
Participants
Start Date
May 2, 2019
Primary Completion Date
April 17, 2024
Study Completion Date
February 26, 2025
Eltrombopag
"Starting dose for eltrombopag will be based on manufacturer recommendations, and drug will be titrated to effect per guidelines.~* Children 1 to 5 years: Initial: 25 mg once daily~* Children ≥6 years and Adolescents: Initial: 50 mg once daily (25 mg once daily for patients of East-Asian ethnicity \[e.g., Chinese, Japanese, Korean, Taiwanese\])~Dose should be titrated based on platelet response. Maximum dose: 75 mg once daily."
Steroids
Prednisone/Prednisolone 4mg/kg/day (Max 120 mg/day) x 4 day
IVIG
IVIG 1 g/kg x1 (no steroids for pre-medication or adjunctive therapy)
Rho(D) Immune Globulin
Anti-D globulin 75 mcg/kg x1 (no steroids for pre-medication or adjunctive therapy)
Columbia University Irving Medical Center, New York
Weill Cornell Medical College, New York
The Children's Hospital of Philadelphia, Philadelphia
Children's National Medical Center, Washington D.C.
Duke University Medical Center, Durham
Levine Cancer Institute, Charlotte
Alfac Cancer and Blood Disorder Center: Scottish Rite, Atlanta
University of Florida College of Medicine, Gainesville
Children's of Alabama, Birmingham
St. Jude Children's Hospital, Memphis
Nationwide Children's Hospital, Columbus
Riley Hospital for Children-Indiana University, Indianapolis
University of Wisconsin, Madison
Children's Hospital and Clinics of Minnesota, Minneapolis
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
University of Nebraska Medical Center, Omaha
Arkansas Children's Hospital, Little Rock
Texas Children's Hospital, Houston
Children's Hospital Colorado, Aurora
Phoenix CHildren's Hospital, Phoenix
Children's Hospital of Orange County, Orange
UCSF Benioff Children's Hospital, San Francisco
Randall Children's Hospital, Portland
Oregon Health and Science University, Portland
Boston Children's Hospital, Boston
Hackensack University Medical Center, Hackensack
Hasbro Children's Hospital, Providence
Boston Children's Hospital
OTHER
University of California, San Francisco
OTHER
Baylor College of Medicine
OTHER