Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors and Risk of Cardiovascular Events

CompletedOBSERVATIONAL
Enrollment

419,734

Participants

Timeline

Start Date

October 1, 2018

Primary Completion Date

October 1, 2019

Study Completion Date

October 1, 2019

Conditions
Type2 DiabetesMyocardial InfarctionIschemic StrokeCardiovascular DeathHeart FailureAll-Cause Mortality
Interventions
DRUG

Sodium-glucose cotransporter 2 (SGLT2) inhibitors

Exposure to SGLT2 will be defined as a prescription for a SGLT2 inhibitor alone (canagliflozin, dapagliflozin, empagliflozin) or in combination with non-DPP4 inhibitor drugs at cohort entry date.

DRUG

Dipeptidyl peptidase-4 (DPP-4) inhibitors

Exposure to DPP-4 will be defined as a prescription for a DPP-4 inhibitor (alogliptin, linagliptin, saxagliptin, sitagliptin, vildagliptin) alone or in combination with non-SGLT2 inhibitor drugs at cohort entry date.

Trial Locations (1)

H3T1E2

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal

All Listed Sponsors
collaborator

Drug Safety and Effectiveness Network, Canada

OTHER

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

Canadian Network for Observational Drug Effect Studies, CNODES

OTHER

NCT03939624 - Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors and Risk of Cardiovascular Events | Biotech Hunter | Biotech Hunter