NCT03939520View on ClinicalTrials.gov

Management of Progressive Disease in Idiopathic Pulmonary Fibrosis

PHASE4RecruitingINTERVENTIONAL
Enrollment

378

Participants

Timeline

Start Date

June 11, 2020

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2026

Conditions
Progressive Idiopathic Pulmonary Fibrosis
Interventions
DRUG

pirfenidone and nintedanib

The experimental group will receive pirfenidone 2403 mg per day (at least 1602 mg) in combination with nintedanib 300 mg per day (at least 200 mg) during 24 weeks.

DRUG

pirfenidone or nintedanib

The second intervention group will switch from one monotherapy during 24 weeks: with pirfenidone 2403 mg per day (at least 1602 mg) or nintedanib 300 mg per day (at least 200 mg) to the other monotherapy (nintedanib in patients who received pirfenidone as first line therapy before inclusion and conversely).

DRUG

pirfenidone or nintedanib

The control group will keep on the same monotherapy during 24 weeks: with pirfenidone 2403 mg per day (at least 1602 mg) or nintedanib 300 mg per day (at least 200 mg) to the other monotherapy (nintedanib in patients who received pirfenidone as first line therapy before inclusion and conversely).

Trial Locations (21)

Unknown

RECRUITING

CHU d'Angers, Angers

NOT_YET_RECRUITING

Centre Hospitalier de la côte Basque, Bayonne

NOT_YET_RECRUITING

CHRU de Besançon - Hôpital Jean Minjoz, Besançon

RECRUITING

AP - HP - Hôpital Avicenne, Bobigny

RECRUITING

CHRU Hôpital Cavale Blanche, Brest

RECRUITING

Hôpital Pneumologique et Cardiovasculaire Louis Pradel, Bron

RECRUITING

CHU de Caen - Hôpital de la Côte de Nacre, Caen

RECRUITING

CHU Dijon Bourgogne - Hôpital François Mitterrand, Dijon

RECRUITING

CHRU de Lille - Hôpital Albert Calmette, Lille

RECRUITING

CHU de Marseille - Hôpital Nord, Marseille

RECRUITING

CHRU de Montpellier - Hôpital Arnaud de Villeneuve, Montpellier

RECRUITING

CHU - Hôpital G.R. Laennec, Nantes

RECRUITING

CHU de Nice, Hôpital Pasteur, Nice

RECRUITING

APHP - Hôpital Xavier Bichat-Claude Bernard, Paris

RECRUITING

Groupe Hospitalier Paris Saint Joseph, Paris

NOT_YET_RECRUITING

Ch de Cornouaille, Quimper

RECRUITING

CHU Rennes - Hôpital Pontchaillou, Rennes

RECRUITING

CHU de Toulouse - Hôpital Larrey, Toulouse

RECRUITING

CHRU, Tours - Hôpital Bretonneau, Tours

RECRUITING

CHU Nancy - Hôpital Brabois, Vandœuvre-lès-Nancy

RECRUITING

Hôpital Robert Schuman, Vantoux

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER