Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

855

Participants

Timeline

Start Date

June 25, 2019

Primary Completion Date

January 31, 2022

Study Completion Date

January 31, 2027

Conditions
Renal Cell Carcinoma
Interventions
DRUG

Cabozantinib

Specified dose on specified days.

BIOLOGICAL

Nivolumab

Specified dose on specified days.

BIOLOGICAL

Ipilimumab

Specified dose on specified days.

DRUG

Cabozantinib-matched placebo

Specified dose on specified days.

Trial Locations (159)

333

Exelixis Clinical Site #173, Taoyuan District

404

Exelixis Clinical Site #142, Taichung

1000

Exelixis Clinical Site #112, Brussels

1090

Exelixis Clinical Site #126, Vienna

1122

Exelixis Clinical Site #39, Budapest

2065

Exelixis Clinical Site #33, Sydney

2109

Exelixis Clinical Site #27, North Ryde

2217

Exelixis Clinical Site #35, Kogarah

2640

Exelixis Clinical Site #32, Albury

2700

Exelixis Clinical Site #98, Wiener Neustadt

3128

Exelixis Clinical Site #23, Box Hill

3204

Exelixis Clinical Site #122, Hamilton

3350

Exelixis Clinical Site #9, Ballarat

3500

Exelixis Clinical Site #146, Hasselt

4020

Exelixis Clinical Site #76, Linz

4101

Exelixis Clinical Site #17, South Brisbane

4102

Exelixis Clinical Site #14, Woolloongabba

5000

Exelixis Clinical Site #18, Adelaide

5006

Exelixis Clinical Site #11, North Adelaide

5020

Exelixis Clinical Site #75, Salzburg

6008

Exelixis Clinical Site #26, Subiaco

6021

Exelixis Clinical Site #148, Newtown

7624

Exelixis Clinical Site #51, Pécs

10002

Exelixis Clinical Site #138, Taipei

10032

Exelixis Clinical Site #159, New York

10065

Exelixis Clinical Site #8, New York

13210

Exelixis Clinical Site #19, Syracuse

13620

Exelixis Clinical Site #147, Seongnam-si

14004

Exelixis Clinical Site #49, Córdoba

15232

Exelixis Clinical Site #12, Pittsburgh

15706

Exelixis Clinical Site #53, Santiago de Compostela

20116

Exelixis Clinical Site #123, Aguascalientes

20520

Exelixis Clinical Site #52, Turku

21287

Exelixis Clinical Site #58A, Baltimore

22031

Exelixis Clinical Site #64, Fairfax

27100

Exelixis Clinical Site #59, Pavia

28009

Exelixis Clinical Site #34, Madrid

28040

Exelixis Clinical Site #94, Madrid

28041

Exelixis Clinical Site #20, Madrid

28050

Exelixis Clinical Site #55, Madrid

28204

Exelixis Clinical Site #101, Charlotte

29425

Exelixis Clinical Site #102, Charleston

29572

Exelixis Clinical Site #5, Myrtle Beach

30318

Exelixis Clinical Site #3, Atlanta

31008

Exelixis Clinical Site #45, Pamplona

31059

Exelixis Clinical Site #42, Toulouse

33011

Exelixis Clinical Site #96, Oviedo

33075

Exelixis Clinical Site #86, Bordeaux

33176

Exelixis Clinical Site #44, Miami

33486

Exelixis Clinical Site #29, Boca Raton

33520

Exelixis Clinical Site #56, Tampere

34295

Exelixis Clinical Site #80, Montpellier

35042

Exelixis Clinical Site #125, Rennes

35128

Exelixis Clinical Site #61, Padua

37000

Exelixis Clinical Site #167, León

37203

Exelixis Clinical Site #10, Nashville

37232

Exelixis Clinical Site #38, Nashville

41124

Exelixis Clinical Site #60, Modena

45070

Exelixis Clinical Site #169, Zapopan

46009

Exelixis Clinical Site #74, Valencia

47014

Exelixis Clinical Site #41, Meldola

48018

Exelixis Clinical Site #70, Faenza

48149

Exelixis Clinical Site #139, Münster

48201

Exelixis Clinical Site #15, Detroit

49100

Exelixis Clinical Site #97, Petah Tikva

50005

Exelixis Clinical Site #89, Králová

51726

Exelixis Clinical Site #65, Reims

52100

Exelixis Clinical Site #47, Arezzo

53792

Exelixis Clinical Site #13, Madison

54519

Exelixis Clinical Site #67, Vandœuvre-lès-Nancy

55131

Exelixis Clinical Site #164, Mainz

60596

Exelixis Clinical Site #117, Frankfurt am Main

60612

Exelixis Clinical Site #95, Chicago

63110

Exelixis Clinical Site #4, St Louis

64132

Exelixis Clinical Site #24, Kansas City

64710

Exelixis Clinical Site #134, Monterrey

67000

Exelixis Clinical Site #128, Strasbourg

67200

Exelixis Clinical Site #90, Strasbourg

68000

Exelixis Clinical Site #132, Oaxaca City

68130

Exelixis Clinical Site #2, Omaha

69120

Exelixis Clinical Site #127, Heidelberg

69373

Exelixis Clinical Site #78, Lyon

72000

Exelixis Clinical Site #71, Le Mans

72076

Exelixis Clinical Site #115, Tübingen

75015

Exelixis Clinical Site #150, Paris

76000

Exelixis Clinical Site #131, Querétaro

76090

Exelixis Clinical Site #161, Querétaro

84101

Exelixis Clinical Site #88, Beersheba

90419

Exelixis Clinical Site #171, Münster

92093

Exelixis Clinical Site #116, La Jolla

94800

Exelixis Clinical Site #37, Villejuif

97239

Exelixis Clinical Site #107, Portland

98109

Exelixis Clinical Site #57, Seattle

99208

Exelixis Clinical Site #1, Spokane

119074

Exelixis Clinical Site #77, Singapore

169610

Exelixis Clinical Site #40, Singapore

3109601

Exelixis Clinical Site #81, Haifa

4428164

Exelixis Clinical Site #121, Kfar Saba

4810561

Exelixis Clinical Site #85, Temuco

5265601

Exelixis Clincal Site #129, Ramat Gan

7500921

Exelixis Clinical Site #91, Santiago

8420383

Exelixis Clinical Site #100, Santiago

9112001

Exelixis Clinical Site #84, Jerusalem

92868-3201

Exelixis Clinical Site #166, Orange

04074

Exelixis Clinical Site #69, Scarborough

02114

Exelixis Clinical Site #7B, Boston

02215

Exelixis Clinical Site #7A, Boston

Exelixis Clinical Site #7C, Boston

01805

Exelixis Clinical Site #6, Burlington

B1629ODT

Exelixis Clinical Site #153, Pilar

S2000KZE

Exelixis Clinical Site #109, Rosario

T4000

Exelixis Clinical Site #73, San Miguel de Tucumán

C1125ABD

Exelixis Clinical Site #54, Buenos Aires

C1120AAT

Exelixis Clinical Site #63, CABA

C1426ANZ

Exelixis Clinical Site #110, Ciudad Autonoma de Buenos Aire

X5004

Exelixis Clinical Site #120, Córdoba

30130-090

Exelixis Clinical Site #154, Belo Horizonte

80530-010

Exelixis Clinical Site #155, Curitiba

90050-170

Exelixis Clinical Site #158, Porto Alegre

90110-270

Exelixis Clinical Site #140, Porto Alegre

90610-000

Exelixis Clinical Site #163, Porto Alegre

14784-400

Exelixis Clinical Site #168, Barretos

15090-000

Exelixis Clinical Site #162, São José do Rio Preto

01323-001

Exelixis Clinical Site #119, São Paulo

01327-001

Exelixis Clinical Site #141, São Paulo

T2N 4N2

Exelixis Clinical Site #22, Calgary

R3E 0V9

Exelixis Clinical Site #105, Winnipeg

K1H 8L6

Exelixis Clinical Site #46, Ottawa

M4N 3M5

Exelixis Clinical Site #25, Toronto

H3T 1E2

Exelixis Clinical Site #113, Montreal

140 59

Exelixis Clinical Site #114, Prague

150 06

Exelixis Clinical Site #118, Prague

00029

Exelixis Clinical Site #50, Helsinki

06189

Exelixis Clinical Site #66, Nice

077477

Exelixis Clinical Site #137, Jena

01307

Exelixis Clinical Site #124, Dresden

Unknown

Exelixis Clinical Site #28, Hong Kong

Exelixis Clinical Site #136, Shatin

Exelixis Clinical Site #111, Tuenmen

06132

Exelixis Clinical Site #104, Perugia

05100

Exelixis Clinical Site #68, Terni

03100

Exelixis Clinical Site #160, Mexico City

1105 AZ

Exelixis Clinical Site #144, Amsterdam

3015 GD

Exelixis Clinical Site #149, Rotterdam

21-500

Exelixis Clinical Site #31, Biała Podlaska

85-796

Exelixis Clinical Site #62, Bydgoszcz

80-219

Exelixis Clinical Site #135, Gdansk

05-400

Exelixis Clinical Site #99, Otwock

60-693

Exelixis Clinical Site #83, Poznan

03722

Exelixis Clinical Site #143, Seoul

05505

Exelixis Clinical Site #151, Seoul

06351

Exelixis Clinical Site #152, Seoul

08035

Exelixis Clinical Site #43, Barcelona

08036

Exelixis Clinical Site #36, Barcelona

CB2 0QQ

Exelixis Clinical Site #72, Cambridge

G12 0YN

Exelixis Clinical Site #93, Glasgow

EC1A 7BE

Exelixis Clinical Site #30, London

W6 8RF

Exelixis Clinical Site #172, London

M20 4BX

Exelixis Clinical Site #92, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Exelixis

INDUSTRY