A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion DMDs for RMS (MASTER-2)

CompletedOBSERVATIONAL
Enrollment

291

Participants

Timeline

Start Date

July 22, 2019

Primary Completion Date

November 11, 2024

Study Completion Date

November 11, 2024

Conditions
Multiple Sclerosis
Interventions
DRUG

Cladribine Tablets

No intervention will be administered as a part of this study. Participants will receive cladribine tablets as per investigator discretion and as per United States approved label: 3.5 milligram/kilogram (mg/kg) body weight over 2 years, administered as 1 treatment course of 1.75 mg/kg per year.

Trial Locations (66)

10032

The Trustee of Columbia University in the City of New York, New York

11220

NYU Langone Brooklyn - Brooklyn, Brooklyn

14226

DENT Neurologic Institute, Amherst

19107

Wills Eye Institute - Ocular Oncology Service - Wills Eye Institute, Philadelphia

22182

Multiple Sclerosis Center of Greater Washington, Vienna

22310

Integrated Neurology Services - Dr. Simon Fishman's Office, Alexandria

23226

Neurological Associates, Richmond

23298

Massey Cancer Center - VCU Medical Center, Richmond

23456

Sentara Ambulatory Care Center, Virginia Beach

23502

Meridian Clinical Research (Neurology), Norfolk

24073

Blacksburg Neurology, PC, Christiansburg

27405

Guilford Neurologic Associates, Greensboro

28203

The Charlotte-Mecklenburg Hospital Authority - Carolinas Healthcare System, Charlotte

29650

Premier Neurology Research, P.C., Greer

32751

Neurology Associates, P. A., Maitland

32806

Orlando Health Multiple Sclerosis Comprehensive Care Center - Downtown Orlando, Orlando

33136

University of Miami, Miami

33609

Axiom Clinical Research of Florida, Tampa

33612

University of South Florida, Tampa

33713

Suncoast Neuroscience and Associates, Inc., St. Petersburg

35058

North Central Neurology Associates, P.C., Cullman

36693

University of South Alabama, Mobile

37232

Vanderbilt University Medical Center, Nashville

37922

Neurology, PC, Knoxville

40503

Baptist Health Lexington, Lexington

43235

The Boster Center for Multiple Scelosis, Columbus

44811

Insight Neuroscience LLC, Bellevue

45212

Riverhills Neuroscience, Cincinnati

45459

Dayton Center for Neurological Disorders, Dayton

46804

Fort Wayne Neurological Center, Fort Wayne

48201

Wayne State University (WSU) - Multiple Sclerosis Treatment and Clinical Research Center (MS Center) - Department of Neurology, Detroit

48334

Detroit Clinical Research Center, PC, Farmington Hills

48867

Memorial Healthcare, Owosso

53215

Ascension St. Francis Center for Neurological Disorders, S.C., Milwaukee

53226

The Medical College of Wisconsin - Endocrinology, Milwaukee

54956

Neuroscience Group of Northeast Wisconsin - DUPLICATE, Neenah

55422

Minneapolis Clinic of Neurology - Neurology, Golden Valley

60008

Northwest Neurology Ltd, Rolling Meadows

62702

Prairie Education & Research, Springfield

66212

College Park Family Care Center, Overland Park

72205

University of Arkansas for Medical Sciences, Little Rock

77030

Baylor College of Medicine IRB, Houston

77429

Northwest Houston Neurology, Cypress

78258

Neurology Center of San Antonio, San Antonio

78503

DHR Health Neurology Institute Neuroimmunology and Multiple Sclerosis, McAllen

78681

Central Texas Neurology Consultants, Round Rock

80113

HCA Research Institute, Englewood

80528

Advanced Neurosciences Research, LLC, Fort Collins

80907

Colorado Springs Neurological Associates, PC - Neurology, Colorado Springs

89128

Neurology Center of Las Vegas, Las Vegas

90048

Regina Berkovich MD PhD INC, West Hollywood

92835

Fullerton Neurology and Headache Center, Fullerton

97225

Providence Neurological Specialties, Portland

98034

MS Center of Evergreen, Kirkland

98405

MultiCare Health System Institute for Research and Innovation - MultiCare Health System Institute for Research, Tacoma

99202

MultiCare Health System Institute for Research and Innovation - MultiCare Health System Institute for Research and, Spokane

06824

Associated Neurologists of Southern Connecticut, PC, Fairfield

Yale University, Fairfield

04401

Northern Light Comprehensive Multiple Sclerosis Care Center, Bangor

02114

Neurological Clinical Research Institute, Boston

02035

Neuro Institute of New England P.C., Foxborough

02481

The Elliot Lewis Center for Multiple Sclerosis Care, Wellesley

01655

UMASS - Neurology, Worcester

27607-6010

Raleigh Neurology Associates, Raleigh

43614-2598

University of Toledo - PARENT, Toledo

23298-0211

VCU Medical Center - Pediatric Neurology, Richmond

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

EMD Serono Research & Development Institute, Inc.

INDUSTRY

NCT03933202 - A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion DMDs for RMS (MASTER-2) | Biotech Hunter | Biotech Hunter