266
Participants
Start Date
September 10, 2019
Primary Completion Date
March 13, 2023
Study Completion Date
March 13, 2023
End-ischemic Hypothermic Oxygenated Machine Perfusion (HOPE)
"In the experimental group, ECD liver grafts will first undergo a classical static cold (4°C) storage with Institute George Lopez (IGL-1)® solution from graft harvesting until transport to the transplantation center. They will then undergo a hypothermic oxygenated perfusion (HOPE) via the portal vein for a period of 1 to 4 hours (minimum 1 hour) after the back-table phase (graft preparation), in parallel with the recipient hepatectomy, using the CE-certified Liver Assist® perfusion pump/device (Organ Assist®, the Netherlands) with Machine Perfusion Solution (Belzer-MPS, CE-certified)."
classic static cold storage
The control group will consist of a classic static cold (4°C) storage with Institute George Lopez (IGL-1)® solution from graft harvesting until liver transplantation, which is the gold standard procedure in liver transplantation
Department of HPB surgery and liver transplantation Pontchaillou University Hospital, Rennes
CHU Grenoble Alpes - Department of HPB surgery and liver transplantation, Grenoble
Department of HPB surgery and liver transplantation Claude Huriez University Hospital, Lille
Hôpital Hautepierre - Department of HPB surgery and liver transplantation, Strasbourg
Hospices Civils de Lyon, Lyon
APHP - Pitié Salpétrière, Paris
Department of HPB surgery and liver transplantation Beaujon University Hospital, Clichy
Department of HPB surgery and liver transplantation Paul Brousse University Hospital, Villejuif
Hospices Civils de Lyon
OTHER