Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM

For both experimental arms: 1.2g linezolid 28 days, followed by 600mg linezolid for 28 days

For both experimental arms: additional 25mg/kg (making a total of 35mg/kg) rifampicin, for the first 56 days of treatment

For only one of the experimental arms: 1000mg of aspirin daily for 56 days.

10mg/kg oral rifampicin, 5mg/kg oral isoniazid, 15mg/kg oral ethambutol, 25mg/kg oral pyrazinamide daily for 56 days.

Dexamethasone according to doses of Thwaites criteria for the first 8 weeks of anti-tuberculous treatment. Doses differ according to participants Medical Research Council (MRC) grade. Given orally if participant can swallow and intravenously if they cannot.