58
Participants
Start Date
February 20, 2020
Primary Completion Date
September 30, 2027
Study Completion Date
September 30, 2027
Biospecimen Collection
Undergo collection of blood
Dabrafenib Mesylate
Given PO
Lumbar Puncture
Undergo lumbar puncture
Magnetic Resonance Imaging
Undergo MRI
Radiation Therapy
Undergo RT
Trametinib Dimethyl Sulfoxide
Given PO
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Lehigh Valley Hospital-Cedar Crest, Allentown
Children's Hospital of Philadelphia, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
East Carolina University, Greenville
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
Medical University of South Carolina, Charleston
BI-LO Charities Children's Cancer Center, Greenville
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Sacred Heart Hospital, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Saint Mary's Medical Center, West Palm Beach
Tampa General Hospital, Tampa
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
Corewell Health Children's, Royal Oak
C S Mott Children's Hospital, Ann Arbor
Children's Hospital of Michigan, Detroit
Bronson Methodist Hospital, Kalamazoo
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Lurie Children's Hospital-Chicago, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Cardinal Glennon Children's Medical Center, St Louis
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Scott and White Memorial Hospital, Temple
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Dell Children's Medical Center of Central Texas, Austin
Children's Hospital Colorado, Aurora
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Banner Children's at Desert, Mesa
University of New Mexico Cancer Center, Albuquerque
Children's Hospital Los Angeles, Los Angeles
Cedars Sinai Medical Center, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
Miller Children's and Women's Hospital Long Beach, Long Beach
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
Kaiser Permanente-Oakland, Oakland
University of California Davis Comprehensive Cancer Center, Sacramento
Kapiolani Medical Center for Women and Children, Honolulu
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Mary Bridge Children's Hospital and Health Center, Tacoma
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Yale University, New Haven
Eastern Maine Medical Center, Bangor
Walter Reed National Military Medical Center, Bethesda
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Saint Joseph's Regional Medical Center, Paterson
Rhode Island Hospital, Providence
HIMA San Pablo Oncologic Hospital, Caguas
National Cancer Institute (NCI)
NIH