32
Participants
Start Date
October 29, 2018
Primary Completion Date
October 8, 2019
Study Completion Date
October 8, 2019
Factor XII dosage
Factor XII (FXII, Hageman factor) will be measured in plasma. It is converted to FXIIa by an activator. The FXIIa protease cleaves a chromogenic substrate and releases p-nitroaniline (pNA), which can be measured photometrically.
p.Thr328Lys mutation detection
Sequencing of exon 9 of franking introns of FXII, for identification of the p.Thr328Lys mutation.
Videocapillaroscopy
It is an optical method to visualize the most superficial part of the cutaneous microcirculatory network. It provides morphological information.
CHU Brugmann, Brussels
Brugmann University Hospital
OTHER