An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

98

Participants

Timeline

Start Date

June 4, 2019

Primary Completion Date

September 22, 2022

Study Completion Date

October 30, 2025

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

encorafenib

self-administered orally

DRUG

binimetinib

self-administered orally

Trial Locations (159)

10021

Memorial Sloan Kettering Cancer Center David H Koch Center for Cancer Care, New York

Weill Cornell Eye Associates, New York

Weill Cornell Medical College - New York Presbyterian Hospital, New York

10043

S.S.D. Oncologia Polmonare, Orbassano

SCDO Cardiologia, Orbassano

SCDU Anatomia Patologica, Orbassano

SCDU Oftalmologia, Orbassano

SCDU Radiodiagnostica e S.S. Medicina Nucleare, Orbassano

10065

Memorial Sloan Kettering Cancer Center, New York

Weill Cornell Medical College - New York Presbyterian Hospital, New York

10126

Dermatologia Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino

14004

Grupo Cardiologico Corpal (Hospital de la Cruz Roja), Córdoba

Hospital Universitario Reina Sofia, Córdoba

15146

UPMC Hillman Cancer Center Monroeville, Monroeville

15232

UPMC Hillman Cancer Center, Pittsburgh

15237

UPMC Hillman Cancer Center - Passavant (HOA), Pittsburgh

UPMC Hillman Cancer Center - Passavant (OHA), Pittsburgh

15243

UPMC Hillman Cancer Center - Upper St. Clair, Pittsburgh

15601

UPMC Hillman Cancer Center - Arnold Palmer - Mt View, Greensburg

16505

UPMC Hillman Cancer Center Erie, Erie

17402

Weaver Eye Associates, York

17403

WellSpan Oncology Research, York

20132

Departimento Oncologia Medica, Milan

Unita Operativa di Oculistica: UO Oncologia Oculare e Immunopatologia oculare, Milan

Unita Operativa Radiologia, Milan

UO Anatomia e lstologia Patologica, Milan

UO Dermatologia e Cosmetologia, Milan

UO Medicina Nucleare, Milan

IRCCS Ospedale San Raffaele, Milan

21224

Johns Hopkins Bayview Medical Center, Baltimore

21231

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore

21287

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore

The Johns Hopkins Wilmer Eye Institute, Baltimore

27710

Duke Cancer Center, Durham

28034

Hospital Universitario Ramon y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28222

Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda

29010

Hospital Regional Universitario de Malaga - Hospital General, Málaga

Centro Hospitalario Integral Privado (CHIP), Málaga

30097

Winship Cancer Institute @ Emory Johns Creek Hospital, Johns Creek

30308

Winship Cancer Institute @ Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital, Atlanta

Winship Cancer Institute, Emory University, Atlanta

30342

Winship Cancer Institute @ Emory Saint Joseph's Hospital, Atlanta

32003

Florida Cancer Specialists, Fleming Island

32159

Florida Cancer Specialist, The Villages

32308

Florida Cancer Specialists PAN - SCRI - PPDS, Tallahassee

32605

Florida Cancer Specialist, Gainesville

32701

Florida Cancer Specialist, Altamonte Springs

32763

Florida Cancer Specialist, Orange City

32778

Florida Cancer Specialist, Tavares

32792

Florida Cancer Specialists, Winter Park

32806

Florida Cancer Specialist, Orlando

33511

Florida Cancer Specialist, Brandon

33607

Florida Cancer Specialist, Tampa

33705

Florida Cancer Specialist, St. Petersburg

33761

Florida Cancer Specialist, Clearwater

33770

Florida Cancer Specialists, Largo

33905

Florida Cancer Specialists, Fort Myers

33908

Florida Cancer Specialists, Fort Myers

33909

Florida Cancer Specialists, Cape Coral

33980

Florida Cancer Specialists, Port Charlotte

34102

Florida Cancer Specialists, Naples

34135

Florida Cancer Specialists, Bonita Springs

34232

Florida Cancer Specialists, Sarasota

34236

Florida Cancer Specialists, Sarasota

34285

Florida Cancer Specialists, Venice

34292

Florida Cancer Specialists, Venice

34461

Florida Cancer Specialist, Lecanto

34474

Florida Cancer Specialist, Ocala

34608

Florida Cancer Specialists, Spring Hill

34655

Florida Cancer Specialist, Trinity

37055

Tennessee Oncology, PLLC, Dickson

37066

Tennessee Oncology, PLLC, Gallatin

37067

Tennessee Oncology, PLLC, Franklin

37075

Tennessee Oncology, PLLC, Hendersonville

37076

Tennessee Oncology, PLLC, Hermitage

37090

Tennessee Oncology, PLLC, Lebanon

37129

Tennessee Oncology, PLLC, Murfreesboro

37160

Tennessee Oncology, PLLC, Shelbyville

37167

Tennessee Oncology, PLLC, Smyrna

37203

Tennessee Oncology, PLLC, Nashville

37205

Tennessee Oncology, PLLC, Nashville

37207

Tennessee Oncology, PLLC, Nashville

37211

Tennessee Oncology, PLLC, Nashville

37311

Tennessee Oncology, PLLC, Cleveland

37404

Tennessee Oncology, PLLC, Chattanooga

40138

UO Dermatologia Centro Tumori Cutanei (CTC)- Azienda Ospedaliero, Bologna

UO di Oftalmologia- Azienda Ospedaliero Universitaria Di Bologna, Bologna

UO Medicina Borghi- Azienda Ospedaliero Universitaria Di Bologna, Bologna

UO Radiologia Golfieri- Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi, Bologna

UOC di Anatomia Patologica- Azienda Ospedaliero Universitaria Di Bo logna, Bologna

41009

CERCO, Seville

Hospital Universitario Virgen Macarena, Seville

41013

Hospital Universitario Virgen Del Rocio, Seville

43035

Ohio State Outpatient Care Lewis Center, Lewis Center

43081

The Ohio State University East Hospital Ohio State Outpatient Care New Albany, Westerville

43203

Ohio State CarePoint East, Columbus

The Ohio State University East Hospital, Columbus

43210

The Ohio State University Hospital, Columbus

The Ohio State University James Cancer Hospital, Columbus

The Ohio State University Medical Center - Thoracic Oncology Clinic, Columbus

43212

Ohio State Eye and Ear Institute, Columbus

Stefanie Spielman Comprehensive Breast Cancer, Columbus

43221

Martha Morehouse Medical Plaza, Columbus

43230

Ohio State CarePoint Gahanna, Gahanna

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center - South County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center - St Peters, City of Saint Peters

64057

MidAmerica Division, Inc. c/o Centerpoint Medical Center, Independence

64132

MidAmerica Division, Inc., c/o Research Medical Center, Kansas City

66209

MidAmerica Division, Inc. c/o Menorah Medical Center, Overland Park

77008

Houston Eye Associates - Gramercy Location, Houston

80131

Clinica Oculistica II, 2° Policlinico Federico II, Napli

Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale, Napoli

S. C. Farmacia, Napoli

85364

Yuma Regional Medical Center Cancer Center, Yuma

Yuma Regional Medical Center Ophthalmology, Yuma

Yuma Regional Medical Center, Yuma

90403

UCLA Stein Eye Center Santa Monica (OPH), Santa Monica

90404

UCLA Hematology/Oncology, Santa Monica

97015

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Cancer Institute Newberg Clinic, Newberg

97213

Providence Cancer Institute, Franz Clinic, Portland

97225

Providence Oncology and Hematology Care Clinic - Westside, Portland

98104

Eye associates Northwest, Seattle

98109

Seattle Cancer Care Alliance, Seattle

02114

Massachusetts General Hospital, Boston

Ophthalmic Consultants of Boston (OCB), Boston

Ophthalmic Consultants of Boston Inc, Boston

02115

Beth Israel Deaconess Medical Center, Boston

Brigham and Women's Hospital, Boston

Dana Farber Cancer Institute, Boston

02215-5400

Beth Israel Deaconess Medical Center - 330 Brookline Ave, Boston

02215

Beth Israel Deaconess Medical Center/East, Boston

02459

Dana-Farber Cancer Institute - Chestnut Hill, Newton

07920

Memorial Sloan Kettering Cancer Center Basking Ridge, Basking Ridge

07601

Hackensack University Medical Center, Hackensack

07652

Metropolitan Eye Care, Paramus

15213-2548

UPMC Eye Center, Eye and Ear Institute, Pittsburgh

77030-4009

The University of Texas MD Anderson Cancer Center, Houston

77090-3063

Millennium Research & Clinical Development, Houston

1066 CX

Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam

Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam

1091 AC

OLVG, locatie Oost; Ophthalmology department, Amsterdam

9713 GZ

Ophthalmology department, Groningen

University Medical Center Groningen, Groningen

06351

Samsung Medical Center - PPDS, Seoul

Samsung Medical Center, Seoul

08036

Hospital Clinic de Barcelona, Badalona

08003

Hospital del Mar, Barcelona

08022

CETIR Centro Medico Teknon, Barcelona

08023

Hospital Quiron Salud Barcelona, Barcelona

08035

Hospital Universitario Vall d'Hebron, Barcelona

Universitario Vall d'Hebron, Barcelona

08950

Cetir, Esplugues de Llobregat

08907

lnstitut Catala d'Oncologia_L'Hospitalet, L'Hospitalet de Llobregat

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY