An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis

PHASE2TerminatedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

April 30, 2019

Primary Completion Date

January 27, 2022

Study Completion Date

January 27, 2022

Conditions
Brain Metastases
Interventions
DRUG

encorafenib

taken orally

DRUG

binimetinib

taken orally

Trial Locations (25)

2060

Melanoma Institute Australia, North Sydney

2065

Crows Nest Eye Surgery, Crows Nest

Royal north shore center hospital dermatology clinics, St Leonards

Mater Imaging, Wollstonecraft

2650

UZ Antwerpen, Edegem

77030

MD Anderson Cancer Center, Houston

80045

Rocky Mountain Lions Eye Institute (RMLEI), Aurora

University of Colorado Denver CTO/CTRC - Outpatient., Aurora

University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora

University of Colorado Hospital - Anschutz Outpatient Pavilion, Aurora

University of Colorado Hospital, Aurora

80131

Azienda Universitaria Policlinico Federico II, Napoli

S.C. Cardiologia, Napoli

S.C. Farmacia, Napoli

S.C. Medicina Nucleare e Terapia Metabolica, Napoli

SC Melanoma, Immunoterapia Oncologica e Terapie Innovative, Napoli

U.O. Radiodiagnostica 1, Napoli

90025

The Angeles Clinic And Research Institute, A Cedars-Sinai Affiliate, Los Angeles

90404

The Retina Partners, Santa Monica

94143

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

97239

OHSU Center for Health and Healing, Portland

97239-3011

Oregon Health & Science University Center for Health & Healing 2, Portland

CP1426ANZ

Instituto Médico Especializado Alexander Fleming, Buenos Aires

S2000KZE

Instituto de Oncologia de Rosario, Rosario

C1121ABE

Fundacion CIDEA, CABA

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT03911869 - An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis | Biotech Hunter | Biotech Hunter