Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking

RecruitingOBSERVATIONAL
Enrollment

200

Participants

Timeline

Start Date

June 1, 2022

Primary Completion Date

December 1, 2030

Study Completion Date

December 1, 2030

Conditions
Cannabis UseCannabis SmokingMarijuana SmokingMarijuana Usage
Interventions
DIAGNOSTIC_TEST

Hyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

DIAGNOSTIC_TEST

Computed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

DIAGNOSTIC_TEST

Pulmonary Function Tests (PFTs)

Participants will have their lung function evaluated using PFTs

DIAGNOSTIC_TEST

Six Minute Walk Test (6MWT)

Participants \>35 years of age will perform the six minute walk test as a measure of exercise capacity

DIAGNOSTIC_TEST

Cardiopulmonary exercise testing (CPET)

Participants \<35 will perform cardiopulmonary exercise testing as a measure of exercise capacity

DIAGNOSTIC_TEST

Sputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

DIAGNOSTIC_TEST

Blood analysis

Participants will have their blood drawn and analysed for eosinophil count.

Trial Locations (1)

N6A 5B7

RECRUITING

Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre, London

All Listed Sponsors
lead

Western University, Canada

OTHER

NCT03909477 - Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking | Biotech Hunter | Biotech Hunter