470
Participants
Start Date
July 29, 2019
Primary Completion Date
July 2, 2021
Study Completion Date
December 2, 2021
TECAS Procedure
"Location:~1. Cranial electrical stimulation acupoints: Baihui (DU20) and Yintang (DU29).~2. Auricular electrical stimulation zone: the distribution area of auricular branch of the vagus nerve.~Two electrodes electric stimulation at a frequency of 4/20 Hz will be employed on the cranial acupoints and the auricular zone respectively. The TECAS treatment will consistent of two sessions per day (30 minutes) for 8 consecutive weeks."
Escitalopram
Each subject shall receive oral administration Escitalopram (10-20mg/day, q.d.), as prescribed by clinical psychiatrist with respect to patients' conditions for 8 consecutive weeks.
Insomnia medication
For patients with severe insomnia, stabilizers and benzodiazepines could be prescribed and must be recorded in the case report form.
Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing
Guang'anmen Hospital of the Chinese Academy of Chinese Medical Science, Beijing
Department of Chinese Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen
Department of neurology, The University of Hong Kong-Shenzhen Hospital, Shenzhen
Southwest Medical University, Hospital of Traditional Chinese Medicine, Luzhou
The First Hospital of Hebei Medical University, Hebei
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
OTHER
Beijing First Hospital of integrated Chinese and Western Medicine
OTHER
The First Hospital of Hebei Medical University
OTHER
Southwest Medical University
OTHER
The University of Hong Kong
OTHER