Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

577

Participants

Timeline

Start Date

July 15, 2019

Primary Completion Date

March 20, 2023

Study Completion Date

September 30, 2025

Conditions
Metastatic Non-Squamous Non-Small Cell Lung Cancer
Interventions
BIOLOGICAL

Nivolumab

Nivolumab is an antibody directed at the programmed death receptor-1 (PD-1), blocking its interaction with PD-L1 and PD-L2.

DRUG

Sitravatinib

Sitravatinib is a small molecule inhibitor of receptor tyrosine kinases.

DRUG

Docetaxel

Docetaxel is an anti-neoplastic agent that acts by disrupting the microtubular network in cells.

Trial Locations (261)

1011

Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne

1083

Local Institution - 005-454, Budapest

1121

Local Institution - 005-457, Budapest

1122

Local Institution - 005-455, Budapest

1205

Hopitaux Universitaires de Geneve, Geneva

2045

Local Institution - 005-456, Törökbálint

2650

Local Institution - 005-206, Edegem

2800

Local Institution - 005-450, Tatabánya

2930

Local Institution - 005-201, Brasschaat

3010

Inselspital Universitatsspital Bern, Bern

6000

Local Institution - 005-200, Charleroi

8401

Kantonsspital Winterthur, Winterthur

8582

Local Institution - 005-453, Farkasgyepű

8800

Local Institution - 005-205, Roeselare

9000

Local Institution - 005-202, Ghent

Local Institution - 005-207, Ghent

9023

Local Institution - 005-452, Győr

9600

Local Institution - 005-204, Ronse

9700

Local Institution - 005-451, Szombathely

11042

Local Institution - 005-182, Lake Success

11776

New York Cancer & Blood Specialists - Port Jefferson Medical Oncology, Port Jefferson Station

11794

Local Institution - 005-107, Stony Brook

13009

Local Institution - 005-301, Marseille

13015

Local Institution - 005-312, Marseille

13125

Local Institution - 005-418, Berlin

13790

Local Institution - 005-123, Johnson City

15006

Local Institution - 005-807, A Coruña

15121

Local Institution - 005-612, Alessandria

15706

Local Institution - 005-823, Santiago de Compostela

19044

USOR - Alliance Cancer Specialists - Horsham (Abington Hematology Oncology Associates), Horsham

19111

Local Institution - 005-186, Philadelphia

20141

Local Institution - 005-606, Milan

20900

Local Institution - 005-605, Monza

21079

Local Institution - 005-303, Dijon

21100

Ospedale di Circolo e Fondazione Macchi, Varese

22903

Local Institution - 005-144, Charlottesville

22927

Local Institution - 005-417, Grohansdorf

23007

Local Institution - 005-805, Jaén

23229

Virginia Cancer Institute - West End, Richmond

23538

Local Institution - 005-405, Lübeck

24071

Local Institution - 005-817, León

24408

Hematology Oncology Associates of Fredericksburg, Fredericksburg

26100

Local Institution - 005-611, Cremona

27003

Local Institution - 005-812, Lugo

28006

Hospital Universitario La Princesa, Madrid

Local Institution - 005-808, Madrid

28027

Local Institution - 005-819, Madrid

28034

Local Institution - 005-821, Madrid

28040

Local Institution - 005-813, Madrid

Local Institution - 005-815, Madrid

28041

Local Institution - 005-809, Madrid

28046

Hospital Universitario La Paz, Madrid

28222

Local Institution - 005-806, Majadahonda

29009

Local Institution - 005-801, Málaga

29100

Local Institution - 005-607, Piacenza

29200

Local Institution - 005-307, Brest

30060

Local Institution - 005-119, Marietta

30318

Local Institution - 005-146, Atlanta

30607

University Cancer & Blood Center (UCBC) - Athens, Athens

31904

John B. Amos Cancer Center Research, Columbus

32308

SCRI - Florida Cancer Specialists - Panhandle Research Office, Tallahassee

32804

Local Institution - 005-104, Orlando

33011

Local Institution - 005-803, Oviedo

33021

Memorial Regional Hospital, Hollywood

33140

Mount Sinai Health System, Miami Beach

33308

Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale

33401

Local Institution - 005-154, West Palm Beach

33705

SCRI - Florida Cancer Specialists - North Region Research Office, St. Petersburg

33805

Watson Clinic Cancer and Research Center, Lakeland

33901

Local Institution - 005-120, Fort Myers

34102

Local Institution - 005-120E, Naples

34125

Local Institution - 005-416, Kassel

34298

Local Institution - 005-313, Montpellier

34474

Local Institution - 005-079, Ocala

35016

Local Institution - 005-816, Las Palmas de Gran Canaria

35243

Local Institution - 005-164, Birmingham

35805

Clearview Cancer Institute - Huntsville, Huntsville

36312

Local Institution - 005-818, Vigo

37055

Local Institution - 005-137A, Dickson

Local Institution - 005-137B, Dickson

Local Institution - 005-137C, Dickson

Local Institution - 005-137D, Dickson

Local Institution - 005-137E, Dickson

Local Institution - 005-137F, Dickson

Local Institution - 005-137G, Dickson

Local Institution - 005-137H, Dickson

Local Institution - 005-137I, Dickson

Local Institution - 005-137J, Dickson

Local Institution - 005-137K, Dickson

Local Institution - 005-137L, Dickson

37075

Local Institution - 005-137M, Hendersonville

37203

Local Institution - 005-137, Nashville

38120

Local Institution - 005-195, Memphis

39202

Jackson Oncology Associates - The Hederman Cancer Center, Jackson

40241

Local Institution - 005-153, Louisville

40422

Commonwealth Cancer Center - Frankfort, Danville

43126

Local Institution - 005-600, Parma

43210

Local Institution - 005-181, Columbus

43623

Local Institution - 005-103, Toledo

44646

Tricounty Hematology and Oncology - Massillon, Massillon

44708

Local Institution - 005-196, Canton

44805

Local Institution - 005-316, Saint-Herblain

45136

Local Institution - 005-419, Essen

45242

USOR - Oncology Hematology Care - Blue Ash, Cincinnati

46009

IVO - Fundacion Instituto Valenciano de Oncologia, Valencia

46026

Local Institution - 005-804, Valencia

46237

Franciscan Health Cancer Center Indianapolis, Indianapolis

46526

Local Institution - 005-122, Goshen

46804

Fort Wayne Medical Oncology and Hematology - Fort Wayne South Office, Fort Wayne

47014

Local Institution - 005-610, Meldola

47904

Local Institution - 005-150, Lafayette

48201

Barbara Ann Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

51109

Local Institution - 005-412, Cologne

53127

Local Institution - 005-401, Bonn

53226

Froedtert Hospital, Milwaukee

53792

Local Institution - 005-116, Madison

54911

ThedaCare Regional Cancer Center, Appleton

55131

Local Institution - 005-414, Mainz

55404

Local Institution - 005-127, Minneapolis

56126

Local Institution - 005-609, Pisa

59102

Sisters of Charity of Leavenworth Health St. Marys, Billings

60077

Orchard Healthcare Research, Skokie

60201

Local Institution - 005-110, Evanston

60487

Healthcare Research Network - Tinley Park, Tinley Park

60714

Local Institution - 005-198, Niles

64132

Kansas City Care Health Center - Research Medical Campus, Kansas City

65613

Central Care Cancer Center - Bolivar, Bolivar

66205

Local Institution - 005-169, Westwood

67200

Local Institution - 005-305, Strasbourg

67214

Local Institution - 005-098, Wichita

68100

Local Institution - 005-306, Mulhouse

68114

Methodist Hospital - Omaha, Omaha

68803

Saint Francis Cancer Treatment Center, Grand Island

69008

Local Institution - 005-317, Lyon

69500

Local Institution - 005-310, Bron

70124

Local Institution - 005-602, Bari

72037

Local Institution - 005-309, Le Mans

72401

Local Institution - 005-174, Jonesboro

NEA Baptist Fowler Family Center for Cancer Care, Jonesboro

72762

Highlands Oncology Group - Springdale, Springdale

73100

Local Institution - 005-608, Lecce

73120

Local Institution - 005-088, Oklahoma City

73730

Local Institution - 005-406, Esslingen am Neckar

74245

Local Institution - 005-410, Löwenstein

75018

Local Institution - 005-302, Paris

75020

USOR - Texas Oncology Northeast Texas - Denison, Denison

75063

USOR - US Oncology Investigational Products Center, Irving

75071

Local Institution - 005-125, McKinney

75203

Local Institution - 005-128, Dallas

75231

Local Institution - 005-129, Dallas

75246

Local Institution - 005-126, Dallas

75702

USOR - Texas Oncology Northeast Texas - Cancer and Research Institute - Tyler, Tyler

76031

Local Institution - 005-314, Rouen

76104

The Center for Cancer & Blood Disorders - Fort Worth, Fort Worth

76201

Local Institution - 005-124, Denton

77030

Oncology Consultants - Texas Medical Center, Houston

77070

Local Institution - 005-076, Houston

77090

Millennium Research and Clinical Development, Houston

77479

USOR - Texas Oncology - Sugar Land, Sugar Land

77702

Local Institution - 005-075, Beaumont

78240

Texas Oncology - San Antonio Medical Center, San Antonio

78745

Local Institution - 005-134, Austin

80026

Local Institution - 005-097, Lafayette

80131

Local Institution - 005-604, Napoli

81675

Local Institution - 005-413, München

81925

Local Institution - 005-402, München

82131

Local Institution - 005-403, Gauting

83814

Local Institution - 005-191, Coeur d'Alene

84101

Local Institution - 005-504, Beersheba

85304

Palo Verde Cancer Specialists - Glendale, Glendale

85364

Yuma Regional Medical Center, Yuma

85745

The Oncology Institute of Hope & Innovation - Tucson, Tucson

87042

Local Institution - 005-308, Limoges

87509

Local Institution - 005-411, Immenstadt im Allgäu

89052

The Oncology Institute of Hope & Innovation - Henderson, Henderson

89074

Local Institution - 005-152, Henderson

90017

Los Angeles Hematology Oncology Medical Group, Los Angeles

90095

Local Institution - 005-185, Los Angeles

90211

Local Institution - 005-118, Beverly Hills

90505

Local Institution - 005-192, Torrance

90602

Local Institution - 005-105, Whittier

90720

Cancer and Blood Specialty Clinic, Los Alamitos

90813

Local Institution - 005-096, Long Beach

91325

Local Institution - 005-109, Northridge

91790

Local Institution - 005-090, West Covina

92069

Local Institution - 005-176, San Marcos

92373

Local Institution - 005-177, Redlands

92501

Local Institution - 005-112, Riverside

92663

Local Institution - 005-072, Newport Beach

92835

Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton, Fullerton

93309

Comprehensive Blood and Cancer Center - Bakersfield, Bakersfield

93720

Local Institution - 005-171, Fresno

94000

Local Institution - 005-311, Créteil

94143

University of California San Francisco, San Francisco

94805

Local Institution - 005-304, Villejuif

95123

Local Institution - 005-603, Catania

96813

Straub Medical Center, Honolulu

97213

Providence Portland Medical Center, Portland

97239

Local Institution - 005-073, Portland

98004

Overlake Medical Center and Clinics, Bellevue

98201

Local Institution - 005-082, Everett

98405

Local Institution - 005-081, Tacoma

Northwest Medical Specialties - Tacoma, Tacoma

98684

Local Institution - 005-136, Vancouver

99218

Local Institution - 005-187, Spokane

99437

Local Institution - 005-400, Bad Berka

1311001

Local Institution - 005-505, Zsfat

1834111

Local Institution - 005-500, Afula

5265601

Local Institution - 005-506, Ramat Gan

5822012

Local Institution - 005-502, Holon

7030000

Local Institution - 005-501, Beer Yaakov

9103102

Local Institution - 005-507, Jerusalem

06360

Eastern Connecticut Hematology and Oncology Associates, Norwich

60625-3645

Local Institution - 005-151, Chicago

04074

New England Cancer Specialists - Scarborough, Scarborough

20850-6535

Local Institution - 005-178, Rockville

55426-5000

Local Institution - 005-159, Saint Louis Park

07932

Local Institution - 005-142, Florham Park

07739

Local Institution - 005-163, Little Silver

07039

Cooperman Barnabas Medical Center, Livingston

07871

Regional Cancer Care Associates - Sparta, Sparta

98109--1023

Local Institution - 005-111, Seattle

B-5530

Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne, Yvoir

T2N 4N2

Local Institution - 005-259, Calgary

E1C 6Z8

Local Institution - 005-250, Moncton

E2L 4L2

Saint John Regional Hospital, Saint John

L8V 5C2

Local Institution - 005-252, Hamilton

M5G 2M9

Local Institution - 005-251, Toronto

N8W 2X3

Local Institution - 005-257, Windsor

H3A 0G4

Local Institution - 005-255, Montreal

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

G1V 4G5

Local Institution - 005-258, Québec

06120

Local Institution - 005-408, Halle

00144

Local Institution - 005-614, Roma

5223 GZ

Local Institution - 005-700, 's-Hertogenbosch

1066 CX

Local Institution - 005-703, Amsterdam

1081 HV

Local Institution - 005-711, Amsterdam

4818 CK

Local Institution - 005-707, Breda

3318 AT

Local Institution - 005-713, Dordrecht

9728 NT

Local Institution - 005-702, Groningen

6229 HX

Local Institution - 005-712, Maastricht

6525 GA

Local Institution - 005-714, Nijmegen

3015 GD

Local Institution - 005-710, Rotterdam

3045 PM

Local Institution - 005-705, Rotterdam

2545 AA

Local Institution - 005-709, The Hague

3543 AZ

Local Institution - 005-701, Utrecht

3584 CX

Local Institution - 005-708, Utrecht

8025 AB

Local Institution - 005-706, Zwolle

08916

Local Institution - 005-800, Badalona

08003

Local Institution - 005-822, Barcelona

08028

Local Institution - 005-811, Barcelona

08035

Local Institution - 005-810, Barcelona

CF14 2TL

Velindre University NHS Trust, Cardiff

TR1 3LJ

Local Institution - 005-904, Cornwall

LE1 5WW

University Hospitals of Leicester NHS Trust, Leicester

NW3 2QG

Local Institution - 005-908, London

SW3 6JJ

Local Institution - 005-900, London

The Royal Marsden NHS Foundation Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

HA6 2RN

Local Institution - 005-903, Middlesex

Sponsors
All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Mirati Therapeutics Inc.

INDUSTRY