Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702)

NACompletedINTERVENTIONAL
Enrollment

1,753

Participants

Timeline

Start Date

June 14, 2019

Primary Completion Date

January 6, 2025

Study Completion Date

January 6, 2025

Conditions
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMyelodysplastic SyndromesNon-hodgkin LymphomaHodgkin LymphomaAcquired Aplastic AnemiaSickle Cell Disease
Interventions
OTHER

Donor Search Prognosis Score

Patients will be placed on a study arm after receiving a Donor Search Prognosis Score, which is based on HLA allele frequencies and race/ethnicity. This score predicts the likelihood of successfully identifying a 10/10 matched unrelated donor.Worse search prognosis is associated with racial and ethnic minority status but not with other patient and disease biology characteristics that might influence the success of hematopoietic cell transplantation (HCT). Thus, the use of donor search prognosis in this trial as a tool for biologic assignment to matched unrelated donors vs. mismatched donors provides a mechanism to minimize bias from disease characteristics.

Trial Locations (52)

10029

Mount Sinai Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

14263

Rosewell Park Cancer Institute, Buffalo

19104

Children's Hospital of Philadelphia, Philadelphia

University of Pennsylvania, Philadelphia

20010

Children's National Medical Center, Washington D.C.

21201

University of Maryland, Baltimore

22903

University of Virginia, Charlottesville

23298

Virginia Commonwealth University, Richmond

27157

Wake Forest Baptist Health, Winston-Salem

27599

University of North Carolina, Chapel Hill

27710

Duke University Medical Center, Durham

28204

Levine Cancer Institute, Charlotte

29425

Medical University of South Carolina, Charleston

30322

Children's Healthcare of Atlanta, Atlanta

Emory University, Atlanta

30342

Northside Hospital, Atlanta

32610

University of Florida, Gainesville

33028

Memorial Healthcare System, Pembroke Pines

33136

University of Miami, Miami

33612

H. Lee Moffitt Cancer Center, Tampa

39216

University of Mississippi, Jackson

43205

Nationwide Children's Hospital, Columbus

43210

The Ohio State University, Columbus

44106

University Hospitals Cleveland Medical Center, Cleveland

44195

Cleveland Clinic, Cleveland

46202

Indiana University, Indianapolis

48109

University of Michigan, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin, Madison

55414

University of Minnesota, Minneapolis

55905

Mayo Clinic Rochester, Rochester

60153

Loyola University, Maywood

63110

St. Louis Children's Hospital, St Louis

Washington University in St. Louis, St Louis

64108

Children's Mercy Hospital, Kansas City

68105

University of Nebraska Medical Center - Adults, Omaha

University of Nebraska Medical Center - Pediatrics, Omaha

73104

University of Oklahoma, Oklahoma City

75235

Children's Medical Center Dallas, Dallas

76104

Cook Children's Medical Center, Fort Worth

77030

Baylor College of Medicine, Houston

M.D. Anderson Cancer Center, Houston

84113

University of Utah, Salt Lake City

90027

Children's Hospital Los Angeles, Los Angeles

91010

City of Hope, Duarte

92093

University of California, San Diego Medical Center, La Jolla

94305

Stanford Hospitals and Clinics, Stanford

97239

Oregon Health and Science University, Portland

98109

Fred Hutchinson Cancer Research Center, Seattle

02215

Dana Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

National Cancer Institute (NCI)

NIH

collaborator

Blood and Marrow Transplant Clinical Trials Network

NETWORK

collaborator

National Marrow Donor Program

OTHER

collaborator

Medical College of Wisconsin

OTHER

lead

Center for International Blood and Marrow Transplant Research

NETWORK

NCT03904134 - Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702) | Biotech Hunter | Biotech Hunter