Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

NARecruitingINTERVENTIONAL
Enrollment

468

Participants

Timeline

Start Date

March 4, 2019

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Mechanical Ventilation Complication
Interventions
OTHER

Volume Support Mode Mechanical Ventilation

This is a spontaneous mode of mechanical ventilation that depends on the patient's efforts. A target volume (6 cc/kg of IBW), PEEP and FiO2 are set by the medical team, and the ventilator varies the inspiratory pressure support with each breath to achieve the target volume. The respiratory rate is fully dependent on the patient. Sedation while on mechanical ventilation will be set at a goal RASS of 0 to -2.

OTHER

Assist Control Mode Mechanical Ventilation

This is a controlled mode of mechanical ventilation that is independent of patient's efforts. A tidal volume (6 cc/kg of IBW), respiratory rate, PEEP and FiO2 are set by the medical team. Sedation while on mechanical ventilation will be set at a goal RASS of 0 to -2.

Trial Locations (2)

52242

NOT_YET_RECRUITING

University of Iowa, Iowa City

60637

RECRUITING

The University of Chicago Medical Center, Chicago

All Listed Sponsors
lead

University of Chicago

OTHER