351
Participants
Start Date
April 1, 2019
Primary Completion Date
July 24, 2020
Study Completion Date
July 24, 2020
Multiplex PCR assay for meningitis
CSF from cases to be analysed with a FilmArray ME Panel
Multiplex vertical flow microarrray assay for meningitis
CSF from cases will also undergo analysis with a newly developed prototype for point-of-care diagnostic tool for CNS infections identification. The tool is a DNA-based vertical flow microarray technology printed on paper.
Profiling of blood proteins by multi-analyte Profiling technology
Blood from cases and controls to be analysed using Luminex technology to identify protein profiles associated with severe and non-severe infection. Myxovirus protein A (MxA) will also be analysed by the Luminex assay, to associate MxA levels with severe/non-severe infection.
Typing and whole genome sequencing
Pathogenic strains isolated from nasopharyngeal swabs from cases and controls will undergo whole genome sequencing (WGS) and typing .
Holy Innocents Children's Hospital, Mbarara
Mbarara Regional Referral Hospital, Mbarara
Mbarara University of Science and Technology
OTHER
Science for Life Laboratory
UNKNOWN
Epicentre Mbarara Research Center
UNKNOWN
Stockholm South General Hospital
OTHER
Karolinska Institutet
OTHER