505
Participants
Start Date
May 6, 2019
Primary Completion Date
July 26, 2021
Study Completion Date
May 20, 2024
Pembrolizumab
IV infusion
Lenvatinib
oral capsule
Placebo for lenvatinib
oral capsule
National Taiwan University Hospital ( Site 0211), Taipei
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 0216), Kaoshiung
Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 0509), Budapest
Orszagos Onkologiai Intezet ( Site 0503), Budapest
Uzsoki Utcai Korhaz ( Site 0508), Budapest
Rigshospitalet ( Site 0680), Copenhagen
Macquarie University ( Site 0151), North Ryde
Herlev Hospital ( Site 0681), Herlev
Austin Health-Austin Hospital ( Site 0154), Heidelberg
Monash Health ( Site 0160), Clayton
Peninsula Health Frankston Hospital ( Site 0153), Frankston
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce, Miskolc
Mater Misericordiae Ltd ( Site 0158), South Brisbane
Odense Universitetshospital ( Site 0682), Odense
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0507), Szolnok
Bacs-Kiskun Megyei Korhaz ( Site 0510), Kecskemét
Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 0504), Kaposvár
Aarhus Universitets hospital ( Site 0683), Aarhus N
Aalborg Universitets Hospital ( Site 0684), Aalborg
Markusovszky Egyetemi Oktatokorhaz ( Site 0502), Szombathely
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0002), New York
National Cancer Center ( Site 0196), Goyang-si
Taipei Veterans General Hospital ( Site 0212), Taipei
St. Peter's Hospital Cancer Care Center ( Site 0042), Albany
Hopital de la Timone ( Site 0246), Marseille
Hospital Teresa Herrera - Chuac ( Site 0357), A Coruña
Helios Kliniken Schwerin GmbH ( Site 0278), Schwerin
Thomas Jefferson University Hospital ( Site 0051), Philadelphia
Ospedale San Raffaele-Oncologia Medica ( Site 0309), Milan
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0301), Milan
ASST Grande Ospedale Metropolitano Niguarda ( Site 0307), Milan
Universitaetsklinikum Hamburg-Eppendorf ( Site 0282), Hamburg
Virginia Cancer Institute ( Site 0099), Richmond
Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0277), Lübeck
Staedtisches Krankenhaus Kiel GmbH ( Site 0285), Kiel
Hospital La Princesa ( Site 0862), Madrid
Hospital Universitario Gregorio Maranon ( Site 0352), Madrid
Hospital Universitario HM Sanchinarro ( Site 0356), Madrid
CHIC Quimper ( Site 0245), Quimper
Medical University of South Carolina-Hollings Cancer Center ( Site 0029), Charleston
Northwest Georgia Oncology Centers PC ( Site 0707), Marietta
Clinique Pasteur ( Site 0252), Tolouse
CHU de Bordeaux- Hopital Saint Andre ( Site 0235), Bordeaux
Centro di Riferimento Oncologico CRO ( Site 0304), Aviano
Centre de Cancerologie du Grand Montpellier ( Site 0249), Montpellier
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0454), Istanbul
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0459), Istanbul
Chungnam National University Hospital ( Site 0195), Daejeon
Universitaetsklinikum Giessen und Marburg GmbH ( Site 0284), Marburg
Ege Universitesi Tulay Aktas Onkoloji Hastanesi ( Site 0462), Izmir
Universitaetsmedizin Goettingen ( Site 0281), Göttingen
Ospedale Borgo Roma-Oncologia ( Site 0308), Verona
Policlinico S. Orsola - Malpighi (Bologna) ( Site 0302), Bologna
China Medical University Hospital ( Site 0213), Taichung
Taichung Veterans General Hospital ( Site 0214), Taichung
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0456), Konya
Centre Rene Gauducheau ICO ( Site 0250), Saint-Herblain
Universitaetsklinikum Essen ( Site 0274), Essen
Karmanos Cancer Institute ( Site 0712), Detroit
Institut de Cancerologie de l Ouest Site Paul Papin ( Site 0236), Angers
Centre D Oncologie de Gentilly ( Site 0240), Nancy
Sakarya Universitesi Tip Fakultesi Arastirma Hastanesi ( Site 0460), Sakarya
Chonnam National University Hwasun Hospital ( Site 0194), Hwasun Gun
Joliet Oncology Hematology ( Site 0091), Joliet
University of Chicago ( Site 0039), Chicago
Quincy Medical Group ( Site 0022), Quincy
Mercy Hospital Saint Louis - David C. Pratt Cancer Center ( Site 0095), St Louis
Centre Hospitalier de la Cote Basque ( Site 0239), Bayonne
Institut de Cancerologie Strasbourg Europe ( Site 0232), Strasbourg
Centre Leon Berard ( Site 0244), Lyon
Istituto Tumori Giovanni Paolo II ( Site 0306), Bari
Assaf Harofeh Medical Center ( Site 0556), Ẕerifin
National Cheng Kung University Hospital ( Site 0215), Tainan City
Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0271), Tübingen
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0774), Tulsa
Institut Curie ( Site 0237), Paris
Baylor Scott & White Medical Center - Temple ( Site 0706), Temple
Kaohsiung Chang Gung Memorial Hospital ( Site 0217), Kaohsiung City
Banner MD Anderson Cancer Center ( Site 0016), Gilbert
CHD Vendee-onco-hematologie ( Site 0251), La Roche-sur-Yon
CHU Poitiers ( Site 0253), Poitiers
Comprehensive Cancer Centers of Nevada ( Site 0005), Las Vegas
John Wayne Cancer Institute ( Site 0017), Santa Monica
University of California Irvine Medical Center ( Site 0078), Orange
Community Cancer Institute ( Site 0777), Clovis
Institut Gustave Roussy ( Site 0243), Villejuif
Azienda Ospedaliera per l Emergenza Cannizzaro ( Site 0305), Catania
Seattle Cancer Care Alliance ( Site 0003), Seattle
Cancer Care Northwest ( Site 0009), Spokane
Peking University First Hospital ( Site 0726), Beijing
Fifth Medical Center of CPLA General Hospital ( Site 0732), Beijing
Peking University Third Hospital ( Site 0727), Beijing
Russian Scientific Center of Roentgenoradiology ( Site 0424), Moscow
Central Clinical Hospital with Polyclinic ( Site 0415), Moscow
Medical Rehabilitation Center ( Site 0411), Moscow
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 0414), Yaroslavl
Harbin Medical University Cancer Hospital ( Site 0750), Harbin
Murmansk Regional Oncology Dispensary ( Site 0420), Murmansk
GBUZ Leningrad Regional Clinical Oncology Dispensary ( Site 0426), Kuzmolovskiy Settlement
Clinical Hospital Saint Luka ( Site 0421), Saint Petersburg
Fudan University Shanghai Cancer Center ( Site 0721), Shanghai
Zhongshan Hospital Fudan University ( Site 0725), Shanghai
Nanjing Drum Tower Hospital ( Site 0737), Nanjing
Second Affiliated Hospital, Zhejiang University ( Site 0734), Hangzhou
Zhejiang Provincial People's Hospital ( Site 0735), Hangzhou
The First Affiliated Hospital of Xiamen University ( Site 0743), Xiamen
Chongqing Cancer Hospital ( Site 0741), Chongging
Hunan Cancer Hospital ( Site 0745), Changsha
Hubei Cancer Hospital ( Site 0744), Wuhan
Sun Yat-Sen University Cancer Center ( Site 0752), Guangdong
The First Affiliated Hospital of Guangzhou Medical University ( Site 0749), Guangzhou
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ( Site 0746), Guangzhou
Volga District Medical Center Federal Medical and Biological Agency ( Site 0413), Nizhny Novgorod
Omsk Clinical Oncology Dispensary ( Site 0418), Omsk
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0738), Xian
Cancer Hospital Affiliated to Xinjiang Medical University ( Site 0751), Ürümqi
Ha Emek Medical Center ( Site 0560), Afula
Rambam Medical Center ( Site 0552), Haifa
Meir Medical Center ( Site 0554), Kfar Saba
Rabin Medical Center ( Site 0553), Petah Tikva
Sheba Medical Center ( Site 0551), Ramat Gan
Sourasky Medical Center ( Site 0561), Tel Aviv
Assuta Ashdod Public ( Site 0562), Ashdod
Shaare Zedek Medical Center ( Site 0559), Jerusalem
Hadassah Ein Kerem Medical Center ( Site 0558), Jerusalem
New England Cancer Specialists ( Site 0047), Scarborough
Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0577), Berazategui
Centro de Urología CDU ( Site 0590), Buenos Aires
Instituto Medico Alexander Fleming ( Site 0578), Buenos Aires
Centro Medico Dra De Salvo ( Site 0593), Buenos Aires
Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0585), Viedma
Centro Oncológico de Rosario ( Site 0584), Rosario
Instituto de Investigaciones Metabolicas ( Site 0589), Buenos Aires
CEMAIC ( Site 0581), Córdoba
Centro Oncologico de Integracion Regional. COIR ( Site 0576), Mendoza
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0101), Hamilton
Lakeridge Health ( Site 0103), Oshawa
Sunnybrook Research Institute ( Site 0106), Toronto
CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0104), Québec
CIUSSS de l Estrie Centre Hospitalier Universitaire de Sherbrooke ( Site 0102), Sherbrooke
Azienda Ospedaliera Santa Maria ( Site 0303), Terni
Hirosaki University Hospital ( Site 0123), Hirosaki
National Cancer Center Hospital East ( Site 0128), Kashiwa
Ehime University Hospital ( Site 0137), Tōon
Sapporo Medical University Hospital ( Site 0122), Sapporo
University of Tsukuba Hospital ( Site 0126), Tsukuba
Kitasato University Hospital ( Site 0129), Sagamihara
Nara Medical University Hospital ( Site 0133), Kashihara
Saitama Medical University International Medical Center ( Site 0125), Hidaka
Yamaguchi University Hospital ( Site 0135), Ube
Akita University Hospital ( Site 0124), Akita
Chiba Cancer Center ( Site 0127), Chiba
Nagasaki University Hospital ( Site 0136), Nagasaki
Osaka City University Hospital ( Site 0132), Osaka
Tokushima University Hospital ( Site 0134), Tokushima
Medical Hospital, Tokyo Medical And Dental University ( Site 0130), Tokyo
Ziekenhuis Rijnstate ( Site 0342), Arnhem
Maastricht Universitair Medisch Centrum - MUMC ( Site 0334), Maastricht
VieCuri Medisch Centrum ( Site 0340), Venlo
Amphia Ziekenhuis Breda ( Site 0331), Breda
Deventer Ziekenhuis ( Site 0341), Deventer
Erasmus MC ( Site 0332), Rotterdam
Haga Ziekenhuis ( Site 0333), The Hague
St. Antonius Ziekenhuis ( Site 0335), Utrecht
Szpital Wojewodzki ( Site 1062), Tarnów
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 0535), Wroclaw
Europejskie Centrum Zdrowia Otwock ( Site 0532), Otwock
Urologica Praktyka Lekarska Adam Marcheluk ( Site 0543), Siedlce
Luxmed Onkologia sp. z o. o. ( Site 0541), Warsaw
Szpital Miejski im. Jana Pawła II w Bielsku-Białej ( Site 0542), Bielsko-Biala
Korea University Anam Hospital ( Site 0197), Seoul
Seoul National University Hospital ( Site 0191), Seoul
Severance Hospital ( Site 0192), Seoul
Veterans Health Service Medical Center ( Site 0198), Seoul
Samsung Medical Center ( Site 0193), Seoul
Institut Catala d Oncologia Hospital Germans Trias i Pujol ( Site 0351), Badalona
ICO L Hospitalet ( Site 0361), L'Hospitalet de Llobregat
Xarxa Assistencial Universitaria Manresa ( Site 0354), Manresa
Hospital Infanta Cristina ( Site 0355), Badajoz
Hospital General Universitari Vall d Hebron ( Site 0358), Barcelona
Cukurova Universitesi Tıp Fakultesi Balcalı Hastanesi ( Site 0457), Adana
Ankara Sehir Hastanesi ( Site 0455), Ankara
Antalya Memorial Hospital Department of Medical Oncology ( Site 0461), Antalya
Weston Park Hospital ( Site 0387), Sheffield
Queens Hospital-Purple Zone ( Site 0377), Romford
Lister Hospital ( Site 0376), Stevenage
Kent and Canterbury Hospital ( Site 0390), Canterbury
Royal Preston Hospital ( Site 0379), Preston
Saint Bartholomew s Hospital - London ( Site 0386), London
University College London Hospital NHS Foundation Trust ( Site 0380), London
Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 0378), London
Nottingham University Hospital NHS Trust ( Site 0383), Nottingham
Derriford Hospital ( Site 0388), Plymouth
Royal Stoke University Hospital Univ. Hosps of North Midlands NHST ( Site 0392), Stoke-on-Trent
Eisai Inc.
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY