600
Participants
Start Date
May 1, 2019
Primary Completion Date
January 1, 2026
Study Completion Date
July 31, 2026
Either supine or prone positioning and either CMV or HFOV
"Supine positioning: Subjects randomized to supine positioning will remain supine.~Prone positioning: Subjects randomized to prone positioning will be positioned prone ≥16 hours/day for a maximum of 28 days.~CMV strategy: Low tidal volume to obtain exhaled Vt of 5-7 ml/kg (ideal body weight), PIP goal limited to ≤ 28 cm H2O and lung recruitment maneuver to identify best PEEP then maintained per PEEP-FiO2 grid.~HFOV strategy: Frequency at 8-12 Hz, amplitude (delta-P) 60-90 and mPaw recruitment maneuver."
Perth Children's Hospital, Perth
King Chulalongkorn Memorial Hospital, Bangkok
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Cohen Children's Medical Center, Queens
Penn State Children's Hospital, Hershey
Children's Hospital of Philadelphia, Philadelphia
Bloomberg Children's Center, Johns Hopkins University, Baltimore
Inova Fairfax Medical Campus, Falls Church
Duke Children's Hospital, Durham
Medical University of South Carolina, Charleston
Children's of Alabama, Birmingham
LeBonheur Children's Hospital, Memphis
Norton Children's Hospital, Louisville
UH Rainbow Babies & Children, Cleveland
Riley Hospital for Children at IU Health, Indianapolis
CS Mott Children's Hospital, Ann Arbor
University of Iowa Stead Family Chlldren's Hospital, Iowa City
Children's Hospital of Wisconsin, Milwaukee
American Family Children's Hospital, University of Wisconsin, Madison
Ann & Robert Lurie Children's Hospital of Chicago, Chicago
Children's Hospital and Medical Center, Omaha
Arkansas Children's Hospital, Little Rock
Children's Hospital at Oklahoma University Medical Center, Oklahoma City
Medical City Dallas, Dallas
Children's Health Dallas, Dallas
Texas Children's Hospital, Houston
Children's Hospital of San Antonio, San Antonio
Banner Health, Phoenix
Children's Hospital Orange County, Orange
Stanford Children's Health, Palo Alto
Kapiolani Medical Center for Women and Children, Honolulu
Hospital de Pediatría J. P. Garrahan. SAMIC, Buenos Aires
Children's Hospital at Westmead, Sydney
Hospital SEPACO, São Paulo
Sabara Hospital Infantil, São Paulo
Münster University Hospital, Münster
Rainbow Children's Hospital, Hyderabad
Hadassah Medical Center, Jerusalem
Meyer Children's Hospital, Florence
Instituto Giannina Gasilini, Genova
Bambino Gesu Children's Hospital (Area Rossa Unit), Rome
University of Malaysia Medical Center, Kuala Lumpur
University Medical Center Groningen, Groningen
Chonnam National University Hospital, Gwangju
Faculty of Medicine Ramathibodi Hospital, Bangkok
Shaikh Khalifa Medical City, Abu Dhabi
Birmingham Children's Hospital, Birmingham
University Hospital Leicester NHS Trust, Leicester
Centre Hospitalier Universitaire Sainte Justine, Montreal
National Heart, Lung, and Blood Institute (NHLBI)
NIH
University Medical Center Groningen
OTHER
Boston Children's Hospital
OTHER
University Hospitals Cleveland Medical Center
OTHER
University of Pennsylvania
OTHER