Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing

PHASE4RecruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

May 8, 2019

Primary Completion Date

May 31, 2028

Study Completion Date

May 31, 2028

Conditions
AsthmaInflammation
Interventions
DRUG

Dexamethasone treatment during 3 days

Dexamethasone 1,0 mg oral tablets. The exact daily dose of dexamethasone will be 0.3 mg/kg (maximum 6.0 mg). The recommended administration of all tablets is to crush the tablets to a smooth powder and then mix with jelly or yogurt. The dissolved dexamethasone is given by mouth and it is recommended to give it in relation to a meal/breastfeeding. If a child vomits within 30 min, the same dose will be given one more time after a break.

DRUG

placebo treatment during 3 days

1,0 mg oral tablets. The exact daily dose of lactose (instead of dexamethasone) will be 0.3 mg/kg (maximum 6.0 mg). The recommended administration of all tablets is to crush the tablets to a smooth powder and then mix with jelly or yogurt. The dissolved dexamethasone is given by mouth and it is recommended to give it in relation to a meal/breastfeeding. If a child vomits within 30 min, the same dose will be given one more time after a break.

Trial Locations (8)

Unknown

RECRUITING

Turku University Hospital, Turku

RECRUITING

Haukeland University Hospital, Bergen

RECRUITING

Akershus University Hospital, Oslo

RECRUITING

Ullevål University Hospital, Oslo

RECRUITING

Stavanger University Hospital, Stavanger

RECRUITING

University Hospital of North Norway, Tromsø

RECRUITING

St Olavs Hospital, Trondheim

RECRUITING

Karolinska Universitetssjukhuset, Stockholm

All Listed Sponsors
collaborator

Turku University Hospital

OTHER_GOV

collaborator

Karolinska University Hospital

OTHER

collaborator

Haukeland University Hospital

OTHER

collaborator

University Hospital, Akershus

OTHER

collaborator

Helse Stavanger HF

OTHER_GOV

collaborator

University Hospital of North Norway

OTHER

collaborator

Ullevaal University Hospital

OTHER

lead

St. Olavs Hospital

OTHER