1,195
Participants
Start Date
April 24, 2019
Primary Completion Date
September 2, 2021
Study Completion Date
September 2, 2021
Patiromer
The starting dose of patiromer will be 1 packet/day and may be taken either with food or without food. Based upon the patiromer treatment algorithm patiromer may be increased by 1 packet per day in intervals of at least 1 week (± 3 days). For subjects who become hypokalemic, patiromer may be decreased to a minimum of 0 packets/day. Doses of patiromer will be 0 packets/day, 1 packet/day, 2 packets/day, and 3 packets/day (maximum dose).
Placebos
The starting dose of placebo will be 1 packet/day and may be taken either with food or without food. Based upon the placebo treatment algorithm placebo may be increased by 1 packet per day in intervals of at least 1 week (± 3 days). For subjects who become hypokalemic, placebo may be decreased to a minimum of 0 packets/day. Doses of placebo will be 0 packets/day, 1 packet/day, 2 packets/day, and 3 packets/day (maximum dose).
Investigator Site 64-010, Budapest
Investigator Site 64-002, Budapest
Investigator Site 64-006, Budapest
Investigator Site 64-009, Budapest
Investigator Site 44-009, Brussels
Investigator Site 61-009, Sofia
Investigator Site 61-008, Sofia
Investigator Site 21-012, Buenos Aires
Investigator Site 61-005, Sofia
Investigator Site 61-006, Sofia
Investigator Site 64-007, Kistarcsa
Investigator Site 44-002, Mechelen
Investigator Site 21-009, Santa Fe
Investigator Site 44-007, Leuven
Investigator Site 36-003, Rotterdam
Investigator Site 44-008, Hasselt
Investigator Site 44-003, Genk
Investigator Site 21-010, San Miguel de Tucumán
Investigator Site 44-006, Liège
Investigator Site 61-004, Plovdiv
Investigator Site 64-005, Nyíregyháza
Investigator Site 37-008, Valencia
Investigator Site 21-011, Córdoba
Investigator Site 44-004, Yvoir
Investigator Site 21-005, San Luis
Investigator Site 61-002, Pleven
Investigator Site 21-015, Villa María
Investigator Site 64-001, Kecskemét
Investigator Site 63-012, Batumi
Investigator Site 23-011, Oaxaca City
Investigator Site 61-010, Rousse
Investigator Site 61-003, Burgas
Investigator Site 44-010, Roeselare
Investigator Site 44-001, Ghent
Investigator Site 68-004, Zhytomyr
Investigator Site 11-081, Staten Island
Investigator Site 11-127, The Bronx
Investigator Site 33-020, Berlin
Investigator Site 67-010, Belgrade
Investigator Site 11-040, Manhasset
Investigator Site 67-002, Belgrade
Investigator Site 67-004, Belgrade
Investigator Site 67-008, Belgrade
Investigator Site 11-126, Brooklyn
Investigator Site 11-053, Richmond Hill
Investigator Site 11-021, Stony Brook
Investigator Site 37-010, Castellon
Investigator Site 33-013, Berlin
Investigator Site 62-001, Prague
Investigator Site 35-012, Safed
Investigator Site 62-012, Prague
Investigator Site 67-003, Šabac
Investigator Site 34-010, Genova
Investigator Site 11-165, Erie
Investigator Site 62-009, Prague
Investigator Site 11-082, Hershey
Investigator Site 33-008, Greifswald
Investigator Site 67-005, Niš
Investigator Site 67-007, Niška Banja
Investigator Site 34-004, Milan
Investigator Site 33-005, Hamburg
Investigator Site 68-014, Vinnytsia
Investigator Site 11-023, Columbia
Investigator Site 67-001, Kamenitz
Investigator Site 11-027, Baltimore
Investigator Site 32-018, Saint-Brieuc
Investigator Site 11-158, Norfolk
Investigator Site 11-188, Norfolk
Investigator Site 33-017, Kiel
Investigator Site 34-002, Bergamo
Investigator Site 34-007, Brescia
Investigator Site 37-023, Lleida
Investigator Site 11-065, Morgantown
Investigator Site 62-011, Slaný
Investigator Site 11-018, Greenville
Investigator Site 37-021, Madrid
Investigator Site 37-020, Madrid
Investigator Site 37-026, Madrid
Investigator Site 11-120, Charlotte
Investigator Site 11-075, Charlotte
Investigator Site 37-011, Majadahonda
Investigator Site 33-016, Bremen
Investigator Site 11-157, Lumberton
Investigator Site 37-017, Málaga
Investigator Site 34-012, Piacenza
Investigator Site 11-110, Greenville
Investigator Site 11-098, Greenwood
Investigator Site 11-119, Lancaster
Investigator Site 11-133, Rock Hill
Investigator Site 11-109, Atlanta
Investigator Site 33-022, Hanover
Investigator Site 11-141, Macon
Investigator Site 32-012, Toulouse
Investigator Site 11-015, Columbus
Investigator Site 11-179, Jacksonville
Investigator Site 33-024, Minden
Investigator Site 33-023, Bad Oeynhausen
Investigator Site 11-138, Gainesville
Investigator Site 11-168, Altamonte Springs
Investigator Site 11-171, Orlando
Investigator Site 11-025, Orlando
Investigator Site 11-087, Orlando
Research Site 11-001, Miami Lakes
Research Site 11-002, Miami Lakes
Investigator Site 11-177, Pembroke Pines
Investigator Site 11-078, Homestead
Investigator Site 11-144, Pompano Beach
Investigator Site 32-010, Bordeaux
Investigator Site 11-115, Miami
Investigator Site 11-125, Miami
Investigator Site 11-005, Miami
Investigator Site 11-003, Doral
Investigator Site 11-122, Medley
Investigator Site 11-032, North Miami Beach
Investigator Site 11-099, Tamarac
Investigator Site 11-106, Boynton Beach
Investigator Site 11-164, Greenacres City
Investigator Site 11-028, Brandon
Investigator Site 33-015, Bielefeld
Investigator Site 11-090, Tampa
Investigator Site 11-163, Tampa
Investigator Site 32-005, Montpellier
Investigator Site 11-080, Alexander City
Investigator Site 62-010, Mariánské Lázně
Investigator Site 33-018, Giessen
Investigator Site 11-041, Huntsville
Investigator Site 34-013, San Bonifacio
Investigator Site 11-134, Tullahoma
Investigator Site 11-152, Chattanooga
Investigator Site 11-142, Memphis
Investigator Site 11-083, Memphis
Investigator Site 11-091, Jackson
Investigator Site 32-002, La Tronche
Investigator Site 11-068, Jackson
Investigator Site 62-004, Bílina
Investigator Site 11-061, Owensboro
Investigator Site 11-149, Columbus
Investigator Site 11-187, Toledo
Investigator Site 11-064, Lorain
Investigator Site 23-012, Guadalajara
Investigator Site 34-009, Cona
Investigator Site 23-004, Guadalajara
Investigator Site 33-001, Essen
Investigator Site 62-013, Liberec
Investigator Site 11-129, Munster
Investigator Site 11-117, Merrillville
Investigator Site 37-001, Manises
Investigator Site 11-069, Richmond
Investigator Site 11-121, Livonia
Investigator Site 11-123, Detroit
Investigator Site 11-076, Rochester
Investigator Site 11-189, Rochester
Investigator Site 68-017, Dnipro
Investigator Site 32-013, Reims
Investigator Site 33-010, Leverkusen
Investigator Site 11-045, Milwaukee
Investigator Site 32-001, Nancy
Investigator Site 62-018, Náchod
Investigator Site 62-005, Havlíčkův Brod
Investigator Site 32-014, Lille
Investigator Site 32-009, Tourcoing
Investigator Site 32-011, Valenciennes
Investigator Site 32-016, Valenciennes
Investigator Site 11-031, Arlington Heights
Investigator Site 11-051, Hazel Crest
Investigator Site 33-019, Frankfurt
Investigator Site 68-001, Kharkiv
Investigator Site 68-011, Kharkiv
Investigator Site 68-010, Kharkiv
Investigator Site 68-008, Kharkiv
Investigator Site 68-002, Kharkiv
Investigator Site 11-063, Peoria
Investigator Site 11-137, Peoria
Investigator Site 66-002, Novosibirsk
Investigator Site 11-094, St Louis
Investigator Site 32-003, Pau
Investigator Site 11-154, Kansas City
Investigator Site 62-019, Brno
Investigator Site 33-007, Frankfurt
Investigator Site 23-010, San Pedro Garza García
Investigator Site 62-016, Uherské Hradiště
Investigator Site 68-016, Zaporizhzhya
Investigator Site 11-183, Opelousas
Investigator Site 34-014, Foggia
Investigator Site 11-022, West Monroe
Investigator Site 11-124, Oklahoma City
Investigator Site 62-017, Havířov
Investigator Site 11-074, Bartlesville
Investigator Site 33-012, Heilbronn
Investigator Site 32-004, Paris
Investigator Site 11-104, Allen
Investigator Site 11-185, Allen
Investigator Site 32-008, Paris
Investigator Site 32-017, Paris
Investigator Site 32-007, Paris
Investigator Site 11-170, Denison
Investigator Site 11-046, McKinney
Investigator Site 11-176, Dallas
Investigator Site 11-092, Dallas
Investigator Site 32-020, Lyon
Investigator Site 23-001, Querétaro City
Investigator Site 68-009, Ivano-Frankivsk
Investigator Site 68-005, Ivano-Frankivsk
Investigator Site 32-019, Rouen
Investigator Site 11-060, Fort Worth
Investigator Site 11-029, Lampasas
Investigator Site 11-140, Houston
Investigator Site 11-089, Houston
Investigator Site 11-146, Houston
Investigator Site 11-156, Houston
Investigator Site 11-034, Katy
Investigator Site 11-161, Sugar Land
Investigator Site 11-160, Webster
Investigator Site 11-147, San Antonio
Investigator Site 11-085, San Antonio
Investigator Site 35-008, Ashkelon
Investigator Site 62-015, Litovel
Investigator Site 11-072, Gonzales
Investigator Site 68-006, Lviv
Investigator Site 11-070, Amarillo
Investigator Site 11-095, Aurora
Investigator Site 23-002, Culiacán
Investigator Site 34-001, Caserta
Investigator Site 32-006, Toulon
Investigator Site 11-178, Salt Lake City
Investigator Site 11-153, Phoenix
Investigator Site 11-097, Tucson
Investigator Site 32-015, Poitiers
Investigator Site 11-116, Albuquerque
Investigator Site 11-145, North Las Vegas
Investigator Site 11-049, Las Vegas
Investigator Site 33-014, Nuremberg
Investigator Site 11-017, Long Beach
Investigator Site 11-035, Pasadena
Investigator Site 35-014, Jerusalem
Investigator Site 23-006, Xalapa
Investigator Site 35-001, Jerusalem
Investigator Site 11-058, West Hills
Investigator Site 11-128, Northridge
Investigator Site 11-047, Thousand Oaks
Investigator Site 11-057, Van Nuys
Investigator Site 11-048, La Mesa
Investigator Site 11-162, La Jolla
Investigator Site 11-135, San Diego
Investigator Site 11-086, San Diego
Investigator Site 11-102, Huntington Beach
Investigator Site 11-111, Laguna Hills
Investigator Site 11-112, Santa Ana
Investigator Site 11-052, Bakersfield
Investigator Site 11-136, Fresno
Investigator Site 11-174, Fremont
Investigator Site 11-101, Stockton
Investigator Site 11-044, Sacramento
Investigator Site 33-011, Coburg
Investigator Site 33-003, Würzburg
Investigator Site 11-056, Hillsboro
Investigator Site 11-169, Portland
Investigator Site 35-002, Holon
Investigator Site 33-004, Erfurt
Investigator Site 66-015, Moscow
Investigator Site 66-004, Moscow
Investigator Site 66-011, Moscow
Investigator Site 66-017, Moscow
Investigator Site 66-009, Tver'
Investigator Site 66-012, Petrozavodsk
Investigator Site 66-013, Saint Petersburg
Investigator Site 66-003, Saint Petersburg
Investigator Site 37-022, Murcia
Investigator Site 66-018, Ryazan
Investigator Site 66-016, Kazan'
Investigator Site 66-014, Izhevsk
Investigator Site 66-005, Penza
Investigator Site 66-008, Chelyabinsk
Investigator Site 66-007, Perm
Investigator Site 66-001, Yekaterinburg
Investigator Site 66-010, Kemerovo
Investigator Site 35-016, Tiberias
Investigator Site 35-010, Nahariya
Investigator Site 35-006, Haifa
Investigator Site 35-007, Haifa
Investigator Site 35-003, Hadera
Investigator Site 35-011, Petah Tikva
Investigator Site 35-013, Ramat Gan
Investigator Site 35-009, Be’er Ya‘aqov
Investigator Site 35-005, Jerusalem
Investigator Site 11-004, Jacksonville
Investigator Site 11-132, Boston
Investigator Site 11-071, Lincoln
Investigator Site 11-088, Haddon Heights
Investigator Site 11-054, Linden
Investigator Site 11-148, New Brunswick
Investigator Site 11-107, Newark
Investigator Site 11-151, Brooklyn
Investigator Site 11-073, Buffalo
Investigator Site 11-042, Marion
Investigator Site 21-006, Ciudad Autonoma de Buenos Aire
Investigator Site 21-007, Ciudadela
Investigator Site 21-019, Mar del Plata
Investigator Site 21-020, Ramos Mejía
Investigator Site 21-004, San Nicolás de los Arroyos
Investigator Site 21-021, Córdoba
Investigator Site 21-014, Córdoba
Investigator Site 21-003, Buenos Aires
Investigator Site 21-018, Buenos Aires
Investigator Site 21-008, Buenos Aires
Investigator Site 21-017, Salta
Investigator Site 44-005, Aalst
Investigator Site 22-019, Fortaleza
Investigator Site 22-013, Fortaleza
Investigator Site 22-012, Vitória
Investigator Site 22-021, Salvador
Investigator Site 22-023, Brasília
Investigator Site 22-011, Belo Horizonte
Investigator Site 22-005, Belo Horizonte
Investigator Site 22-004, Uberlândia
Investigator Site 22-010, Campina Grande do Sul
Investigator Site 22-008, Canoas
Investigator Site 22-003, Porto Alegre
Investigator Site 22-015, Porto Alegre
Investigator Site 22-002, Porto Alegre
Investigator Site 22-009, Porto Alegre
Investigator Site 22-025, Porto Alegre
Investigator Site 22-017, Blumenau
Investigator Site 22-007, Aracaju
Investigator Site 22-016, Campinas
Investigator Site 22-018, Ribeirão Preto
Investigator Site 22-020, São José do Rio Preto
Investigator Site 22-024, Rio de Janeiro
Investigator Site 22-014, São Paulo
Investigator Site 22-022, São Paulo
Investigator Site 12-005, Winnipeg
Investigator Site 12-013, St. John's
Investigator Site 12-008, Cambridge
Investigator Site 12-012, London
Investigator Site 12-010, Newmarket
Investigator Site 12-002, Toronto
Investigator Site 12-009, Greenfield Park
Investigator Site 12-006, Sherbrooke
Investigator Site 12-004, Trois-Rivières
Investigator Site 63-007, Tbilisi
Investigator Site 63-011, Tbilisi
Investigator Site 63-004, Tbilisi
Investigator Site 63-002, Tbilisi
Investigator Site 63-006, Tbilisi
Investigator Site 63-008, Tbilisi
Investigator Site 63-010, Tbilisi
Investigator Site 63-003, Tbilisi
Investigator Site 63-009, Tbilisi
Investigator Site 63-001, Tbilisi
Investigator Site 63-005, Tbilisi
Investigator Site 33-006, Homburg
Investigator Site 33-002, Halle
Investigator Site 33-021, Leipzig
Investigator Site 34-005, Ancona
Investigator Site 37-025, A Coruña
Investigator Site 34-003, Roma
Investigator Site 23-007, Cuauhtémoc
Investigator Site 23-005, Gustavo Adolfo Madero
Investigator Site 36-002, 's-Hertogenbosch
Investigator Site 36-012, Amstelveen
Investigator Site 36-006, Blaricum
Investigator Site 36-009, Dirksland
Investigator Site 36-015, Dordrecht
Investigator Site 36-007, Ede
Investigator Site 36-001, Groningen
Investigator Site 36-013, Helmond
Investigator Site 36-014, Hoorn
Investigator Site 36-010, Schiedam
Investigator Site 36-004, Tilburg
Investigator Site 36-011, Utrecht
Investigator Site 65-007, Bialystok
Investigator Site 65-014, Katowice
Investigator Site 65-012, Kędzierzyn-Koźle
Investigator Site 65-001, Lodz
Investigator Site 65-018, Lodz
Investigator Site 65-019, Olsztyn
Investigator Site 65-015, Ostrowiec Świętokrzyski
Investigator Site 65-021, Pomorskie
Investigator Site 65-003, Poznan
Investigator Site 65-020, Poznan
Investigator Site 65-008, Rzeszów
Investigator Site 65-010, Wroclaw
Investigator Site 65-005, Wroclaw
Investigator Site 65-011, Zgierz
Investigator Site 37-014, Palma de Mallorca
Investigator Site 37-003, Barcelona
Investigator Site 37-005, Santiago de Compostela
Investigator Site 37-024, Marbella
Investigator Site 37-016, San Cristóbal de La Laguna
Investigator Site 37-012, Alicante
Investigator Site 37-015, Badalona
Investigator Site 37-007, Barcelona
Investigator Site 37-002, Barcelona
Investigator Site 37-018, Huelva
Investigator Site 37-004, Madrid
Investigator Site 37-006, Madrid
Investigator Site 37-013, Seville
Investigator Site 37-009, Valencia
Investigator Site 68-012, Kyiv
Investigator Site 68-003, Kyiv
Investigator Site 68-015, Kyiv
Investigator Site 68-013, Kyiv
Investigator Site 68-007, Kyiv
Investigator Site 39-012, Harlow
Investigator Site 39-003, Scunthorpe
Investigator Site 39-005, Dudley
Investigator Site 39-009, Barnsley
Investigator Site 39-016, High Wycombe
Investigator Site 39-008, Inverness
Investigator Site 39-011, Leicester
Investigator Site 39-013, Liverpool
Investigator Site 39-015, London
Investigator Site 39-010, North Shields
Investigator Site 39-007, Swansea
Investigator Site 39-004, York
Collaborators (1)
Syneos Health
OTHER
Vifor Pharma, Inc.
INDUSTRY