5
Participants
Start Date
May 2, 2017
Primary Completion Date
November 30, 2018
Study Completion Date
February 28, 2019
Melatonin Replacement Therapy
Melatonin (Aché Pharmaceutics, Brazil), 3 mg, administered in the evening, 30 minutes before the usual bedtime, every day for 3 months. After discontinuation of melatonin therapy, patients are followed up for 6 months to assess safety parameters and cardiac autonomic activity.
University of São Paulo, São Paulo
University of Sao Paulo
OTHER