842
Participants
Start Date
April 11, 2019
Primary Completion Date
October 2, 2023
Study Completion Date
February 5, 2025
Lenvatinib
Lenvatinib 4 mg or 10 mg capsules at a total daily dose of 20 mg taken by mouth once per day.
Pembrolizumab
Pembrolizumab 200 mg IV infusion given on Day 1 of each cycle.
Paclitaxel
Paclitaxel 175 mg/m\^2 IV infusion given on Day 1 of each cycle.
Carboplatin
Carboplatin 10 mg/mL IV infusion at a total dose of are-under-the-curve (AUC) 6 (per Calvert's formula) given on Day 1 of each cycle.
Linkou Chang Gung Memorial Hospital ( Site 1901), Taoyuan District
China Medical University Hospital ( Site 1903), Taichung
Medizinische Universitat Wien ( Site 3300), Vienna
Cliniques Universitaires Saint-Luc ( Site 3203), Brussels
Prince of Wales Hospital [Australia] ( Site 1603), Randwick
Chris OBrien Lifehouse ( Site 1605), Camperdown
Royal North Shore Hospital ( Site 1600), St Leonards
The Crown Princess Mary Cancer Centre - Westmead Hospital ( Site 1602), Westmead
UZA University Hospital Antwerp ( Site 3204), Edegem
UZ Leuven ( Site 3200), Leuven
Epworth Freemasons Hospital ( Site 1609), Melbourne
Monash Health ( Site 1606), Clayton
Mater Misericordiae Ltd ( Site 1608), South Brisbane
Centro Oncologico Riojano Integral ( Site 2605), La Rioja
Sir Charles Gairdner Hospital ( Site 1604), Nedlands
Medizinische Universitat Innsbruck ( Site 3302), Innsbruck
Universitatsklinik fuer Frauenheilkunde und Geburtshilfe ( Site 3301), Graz
AZ Delta ( Site 3206), Roeselare
AZ Maria Middelares Gent ( Site 3202), Ghent
National Taiwan University Hospital ( Site 1904), Taipei
The Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0206), New York
Memorial Sloan Kettering Cancer Center ( Site 0246), New York
Memorial Sloan Kettering Cancer Center - West Harrison ( Site 0274), Harrison
Taipei Veterans General Hospital ( Site 1900), Taipei
Memorial Sloan Kettering Cancer Center - Nassau ( Site 0275), Uniondale
Memorial Sloan-Kettering Cancer Center at Commack ( Site 0267), Commack
Charite Universitaetsmedizin Berlin ( Site 0609), Berlin
Seoul National University Bundang Hospital ( Site 1802), Seongnam-si
Hospital Universitario Reina Sofia ( Site 1207), Córdoba
University of Rochester ( Site 0238), Rochester
Complejo Hospitalario Universitario A Coruna. CHUAC ( Site 1202), A Coruña
Uludag Universitesi Tip Fakultesi ( Site 1307), Bursa
University of North Carolina- Chapel Hill ( Site 0254), Chapel Hill
Hospital Clinico San Carlos ( Site 1209), Madrid
Khmelnitskiy Regional Onkology Dispensary ( Site 1513), Khmelnitskiy
Hospital Materno Infantil [Malaga, Spain] ( Site 1208), Málaga
Hospital San Lucas Cardiologica del Sureste ( Site 3103), Tuxtla Gutiérrez
Ospedale dell Angelo ( Site 0810), Mestre
Georgia Cancer Center at Augusta University ( Site 0222), Augusta
Centro Estatal de Cancerologia de Chihuahua ( Site 3101), Chihuahua City
University of Miami Health System ( Site 0249), Miami
University of South Alabama, Mitchell Cancer Institute ( Site 0245), Mobile
Ospedale Policlinico S. Orsola-Malpighi ( Site 0803), Bologna
Taichung Veterans General Hospital ( Site 1902), Taichung
Universitaetsklinikum Essen ( Site 0616), Essen
Instituto Valenciano de Oncologia - IVO ( Site 1205), Valencia
Hospital General Universitario de Valencia ( Site 1203), Valencia
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0800), Meldola
Universitaetsklinikum Muenster ( Site 0615), Münster
Clinical oncology dispensary of Dnipro ( Site 1512), Dnipro
City Clinical Hosp.4 of DCC ( Site 1501), Dnipro
Medical Oncology Ospedale San Donato ( Site 0812), Arezzo
Minnesota Oncology Hematology, PA ( Site 8003), Minneapolis
Sanford Cancer Center Oncology Clinic ( Site 0205), Sioux Falls
Roger Maris Cancer Center ( Site 0277), Fargo
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 1511), Kharkiv
Communal non profit enterprise Regional Clinical Oncology Center ( Site 1509), Kharkiv
I CAN Oncology SA de SV ( Site 3102), Monterrey
MI Odessa Regional Oncological Centre ( Site 1504), Odesa
HELIOS Dr. Horst Schmidt Kliniken Wiesbaden ( Site 0623), Wiesbaden
Universitaetsmedizin Mannheim. Klinik fuer Kinder und Jugendmedizin ( Site 0622), Mannheim
IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 0801), Bari
Women's Cancer Care ( Site 0208), Covington
Ospedale Antonio Perrino ( Site 0806), Brindisi
Parkland Health & Hospital System ( Site 0272), Dallas
MI Precarpathian Clinical Oncology Center ( Site 1503), Ivano-Frankivsk
Texas Oncology-The Woodlands ( Site 8000), The Woodlands
University of Colorado Cancer Center ( Site 0204), Aurora
Istituto Nazionale Tumori Fondazione Pascale ( Site 0808), Napoli
Arizona Oncology Associates PC- HOPE ( Site 8005), Tucson
UCLA Hematology and Oncology Clinic (Westwood) ( Site 0233), Los Angeles
Caritas-Krankenhaus St. Josef Regensburg ( Site 0613), Regensburg
Azienda Ospedaliera per l Emergenza Cannizzaro ( Site 0807), Catania
Willamette Valley Cancer Institute and Research Center ( Site 8004), Eugene
Legacy Salmon Creek Medical Center ( Site 0253), Vancouver
Beijing Obstetrics and Gynecology Hospital Capital Medical University ( Site 2505), Beijing
Peking Union Medical College Hospital ( Site 2501), Beijing
Beijing Cancer Hospital ( Site 2504), Beijing
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1100), Moscow
FSBI-FRCC of Special Types Med. Care and Technologies FMBA of Russia ( Site 1102), Moscow
Medical Rehabilitation Center ( Site 1101), Moscow
St.Petersburg Clinical Hospital RAS ( Site 1124), Saint Petersburg
Railway Hospital of OJSC ( Site 1122), Saint Petersburg
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1103), Saint Petersburg
SPb SBHI City Clinical Oncological Dispensary ( Site 1104), Saint Petersburg
Fudan University Shanghai Cancer Center ( Site 2500), Shanghai
Obstetrics and Gynecology Hosp. Fudan University ( Site 2503), Shanghai
Nanjing Maternity and Child Health Care Hospital ( Site 2508), Nanjing
Anhui Provincial Cancer Hospital ( Site 2509), Hefei
Women s Hospital School of Medicine Zhejiang University ( Site 2511), Hangzhou
Zhejiang Cancer Hospital ( Site 2506), Hangzhou
Chongqing Cancer Hospital ( Site 2513), Chongqing
Xiangya Hospital Central-South University ( Site 2512), Changsha
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1108), Kazan'
Hubei Cancer Hospital ( Site 2510), Wuhan
Samara Regional Clinical Oncology Center ( Site 1117), Samara
The First Affiliated Hospital.Sun Yat-sen University ( Site 2507), Guangzhou
Guang Xi Tumour Hospital, Department of Chemotherapy ( Site 2517), Nanning
Siberian State Medical University ( Site 1121), Tomsk
Krasnoyarsk Regional Clinical oncology dispensary ( Site 1118), Krasnoyarsk
The first affiliated Hospital of Xi an Jiaotong University ( Site 2502), Xi'an
The First Affiliated Hospital of Xinjiang Medical University ( Site 2515), Ürümqi
Rambam Medical Center ( Site 0700), Haifa
Meir Medical Center ( Site 0702), Kfar Saba
Chaim Sheba Medical Center ( Site 0707), Ramat Gan
Edith Wolfson Medical Center ( Site 0703), Holon
Smilow Cancer Hospital at Yale New Haven ( Site 0202), New Haven
Maine Medical Partners ( Site 0217), Scarborough
Memorial Sloan-Kettering Cancer Center At Basking Ridge ( Site 0268), Basking Ridge
John Theurer Cancer Center at Hackensack University Med Ctr ( Site 0226), Hackensack
Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0273), Middletown
MSKCC-Bergen ( Site 0276), Montvale
Holy Name Medical Center ( Site 0235), Teaneck
University of Texas Southwestern Medical Center ( Site 0264), Dallas
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 2607), Caba
Hospital Italiano de La Plata ( Site 2601), La Plata
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2606), Mar del Plata
Hospital Aleman ( Site 2600), Buenos Aires
Hospital Italiano de Buenos Aires ( Site 2603), Buenos Aires
Instituto do Cancer do Ceara ( Site 2703), Fortaleza
Hospital Araujo Jorge Associacao de Combate ao Cancer de Goias ( Site 2702), Goiânia
Faculdade de Medicina da Universidade Federal de Minas Gerais ( Site 2708), Belo Horizonte
Hospital de Caridade de Ijui ( Site 2712), Ijuí
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 2701), Porto Alegre
Hospital de Base de Sao Jose de Rio Preto ( Site 2704), São José do Rio Preto
Instituto Nacional do Cancer II ( Site 2707), Rio de Janeiro
Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda ( Site 2706), São Paulo
Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 2713), São Paulo
A.C. Camargo Cancer Center ( Site 2705), São Paulo
Cross Cancer Institute ( Site 0408), Edmonton
BC Cancer-Kelowna - Sindi Ahluwalia Hawkins Centre ( Site 0402), Kelowna
BC Cancer-Vancouver Center ( Site 0412), Vancouver
Juravinski Cancer Centre ( Site 0406), Hamilton
Kingston Health Sciences Centre ( Site 0401), Kingston
The Credit Valley Hospital ( Site 0403), Mississauga
Sunnybrook Research Institute ( Site 0410), Toronto
Princess Margaret Cancer Centre ( Site 0409), Toronto
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0414), Montreal
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0411), Montreal
McGill University Health Centre ( Site 0404), Montreal
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0417), Sherbrooke
Universitaetsklinikum Jena ( Site 0612), Jena
Cork University Hospital ( Site 1400), Cork
St James Hospital ( Site 1401), Dublin
Policlinico Universitario Agostino Gemelli ( Site 0805), Rome
Ehime University Hospital ( Site 2413), Tōon
Kurume University Hospital ( Site 2403), Kurume
Gunma Prefectural Cancer Center ( Site 2404), Ōta
National Hospital Organization Hokkaido Cancer Center ( Site 2408), Sapporo
Hyogo Cancer Center ( Site 2414), Akashi
Nippon Medical School Musashi Kosugi Hospital ( Site 2417), Kawasaki
St. Marianna University School of Medicine Hospital ( Site 2416), Kawasaki
University of the Ryukyus Hospital ( Site 2412), Nakagami-gun
Saitama Medical University International Medical Center ( Site 2410), Hidaka
Saitama Cancer Center ( Site 2406), Kitaadachi-gun
National Defense Medical College Hospital ( Site 2418), Tokorozawa
Kyorin University Hospital ( Site 2402), Mitaka
National Hospital Organization Kyushu Cancer Center ( Site 2405), Fukuoka
Niigata Cancer Center Hospital ( Site 2415), Niigata
Osaka International Cancer Institute ( Site 2409), Osaka
The Cancer Institute Hospital of JFCR ( Site 2401), Tokyo
Showa University Hospital ( Site 2419), Tokyo
Keio University Hospital ( Site 2411), Tokyo
Centro de Investigacion Clinica Gramel ( Site 3107), Mexico City
Centro Oncologico Internacional. SEDNA ( Site 3106), Mexico City
Consultorio Dentro de la Torre Medica Dalinde Oncologia Medica ( Site 3108), Mexico City
Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 1004), Poznan
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1019), Krakow
Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie ( Site 1008), Lublin
Szpital Kliniczny im Ks Anny Mazowieckiej ( Site 1011), Warsaw
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 1009), Warsaw
Bialostockie Centrum Onkologii ( Site 1005), Bialystok
Centrum Onkologii Instytut im. MSC Oddział w Gliwicach ( Site 1017), Gliwice
Instytut Centrum Zdrowia Matki Polki ( Site 1020), Lodz
Seoul National University Hospital ( Site 1801), Seoul
Severance Hospital Yonsei University Health System ( Site 1804), Seoul
Asan Medical Center ( Site 1800), Seoul
Samsung Medical Center ( Site 1803), Seoul
Institut Catala d Oncologia Badalona ( Site 1201), Badalona
Parc de Salut Mar ( Site 1200), Barcelona
Baskent Universitesi Adana Uygulama ve Arastirma Hastanesi ( Site 1303), Adana
Cukurova Uni. Tip Fakultesi ( Site 1302), Adana
Gazi Universitesi Tip Fakultesi ( Site 1308), Ankara
Baskent Universitesi Ankara Hastanesi ( Site 1300), Ankara
Akdeniz Universitesi Tıp Fakultesi ( Site 1301), Antalya
Medical Center Asklepion LLC ( Site 1514), Khodosovka
National Cancer Institute of the MoH of Ukraine ( Site 1510), Kyiv
Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 1507), Kyiv
Kyiv City Clinical Oncology Centre ( Site 1505), Kyiv
Western General Hospital ( Site 1411), Edinburgh
UCLH NHS Foundation Trust ( Site 1405), London
Mount Vernon Cancer Centre ( Site 1409), Northwood
Churchill Hospital ( Site 1406), Oxford
The James Cook University Hospital ( Site 1403), Middlesbrough
Northern Centre for Cancer Care ( Site 1408), Newcastle upon Tyne
Eisai Inc.
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY