46
Participants
Start Date
June 27, 2019
Primary Completion Date
August 31, 2023
Study Completion Date
August 31, 2023
ECG
A 12-lead ECG will be taken for each participant.
Blood test and biobanking
All patients will undergo venepuncture and blood sample will be taken for full blood count, renal function and plasma will be stored for future biomarker analysis.
Trans-thoracic Echocardiogram
A standard TTE will be undertaken to measure severity of AS as well as bi-ventricular function. Speckle-tracking data will be performed offline to assess diastolic function.
Vicorder recording
Measurement of carotid-femoral PWV will be made using the Vicorder technique.
Magnetic Resonance Imaging
Patients will undergo a stress MRI scan of their heart and aorta on a 3T scanner, including 4D flow.
University Hospitals of Leicester NHS Trust, Leicester
University of Leicester
OTHER