Effect of the Sequestrant Colesevelam in Bile Acid Diarrhoea

PHASE4CompletedINTERVENTIONAL
Enrollment

255

Participants

Timeline

Start Date

October 25, 2018

Primary Completion Date

July 1, 2021

Study Completion Date

February 13, 2022

Conditions
Bile Acid MalabsorptionChronic Diarrhea
Interventions
DRUG

Colesevelam Hydrochloride

Colesevelam is a sequestrant that binds bile acids in the intestinal lumen, the bile acids are then excreted with the feces. Colesevelam is registered for treating hypercholesterolemia but it is as other sequestrants (e.g. cholestyramine and colestipol) effective against bile acid diarrhoea.

DRUG

Placebo oral capsule

Inactive placebo tablets over-encapsulated with DB caps AAA

Trial Locations (4)

2650

Hvidovre University Hospital, Hvidovre

4600

Zealand University Hospital, Køge

8200

Aarhus University Hospital, Aarhus

9000

Aalborg University Hospital, Aalborg

All Listed Sponsors
collaborator

Pierre and Marie Curie University

OTHER

lead

Lars Kristian Munck

OTHER

NCT03876717 - Effect of the Sequestrant Colesevelam in Bile Acid Diarrhoea | Biotech Hunter | Biotech Hunter