The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome

NACompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 12, 2016

Primary Completion Date

May 5, 2019

Study Completion Date

November 20, 2020

Conditions
Polycystic Ovary SyndromeOvarian Hyperstimulation Syndrome
Interventions
OTHER

Minimal ovarian stimulation

After obtaining informed consent to participate in the study, the subjects will be randomly divided into the following 4 groups: The group of minimal ovarian stimulation with rec-FSH or HMG. The group of mild ovarian stimulation with rec-FSH or HMG. In all 4 experimental groups, after reaching at least three follicles the size of 12 millimeters (mm), daily administration of 0.25 milligram (mg) Cetrotide (antagonist GnRH) will be started and after reaching at least three follicles the size of 17 mm, 500 microgram Ovitrelle (recombinant Human curionic gonadotropin) will be prescribed. 36 hours later, ovulation process will be done. On the day of Ovitrelle administration, serum levels of estradiol and progesterone will be also evaluated. Based on the patient's condition and the quality of obtained oocytes and embryos, 2 embryos will be transferred.

Trial Locations (1)

16635-148

Royan Institute, Tehran

All Listed Sponsors
lead

Royan Institute

OTHER_GOV

NCT03876145 - The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome | Biotech Hunter | Biotech Hunter