Safety and Pharmacokinetics of MK-2060 in Older Participants With End-Stage Renal Disease on Hemodialysis (MK-2060-004)

PHASE1CompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

April 29, 2019

Primary Completion Date

December 20, 2021

Study Completion Date

December 20, 2021

Conditions
Renal DialysisKidney Failure, Chronic
Interventions
DRUG

MK-2060

"Part 1: Single doses (8 mg, 20 mg, or 40 mg) of MK-2060 will be administered via IV infusion on Day 1.~Part 2: Three doses of 25 mg of MK- 2060 administered via IV infusion on Days 1, 3 and 5; Followed by single doses of 25 mg of MK-2060 administered via IV infusion on Days 8, 15, and 22."

DRUG

Placebo

Part 1: Single dose of placebo will be administered via IV infusion on Day 1. Part 2: Three doses of placebo administered via IV infusion on Days 1, 3 and 5; Followed by single doses of placebo administered via IV infusion on Days 8, 15, and 22.

Trial Locations (3)

32809

Orlando Clinical Research Center ( Site 0002), Orlando

37920

New Orleans Center for Clinical Research ( Site 0001), Knoxville

55114

Prism Research ( Site 0003), Saint Paul

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03873038 - Safety and Pharmacokinetics of MK-2060 in Older Participants With End-Stage Renal Disease on Hemodialysis (MK-2060-004) | Biotech Hunter | Biotech Hunter