Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock

PHASE3CompletedINTERVENTIONAL
Enrollment

408

Participants

Timeline

Start Date

February 19, 2019

Primary Completion Date

September 20, 2021

Study Completion Date

September 20, 2021

Conditions
Septic Shock
Interventions
DRUG

Vitamin C,thiamine,hydrocortisone

"Vitamin C (2g) will be diluted in 100ml 0.9%NACL and administered ivd every 6 hours for 5 days or until participant is discharged from the ICU.~Thiamine(200mg) will be diluted in 100ml 0.9%NACL and administered ivd every 12 hours for 5 days or until participant is discharged from the ICU. Hydrocortisone was administered 200 mg/d as a continuous infusion for 5 days or until participant is discharged from the ICU."

DRUG

Placebo

Normal saline (0.9% NaCl solution) volume to match all components

Trial Locations (1)

225000

Northern Jiangsu Province people's hospital, Yangzhou

All Listed Sponsors
lead

Northern Jiangsu People's Hospital

OTHER

NCT03872011 - Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock | Biotech Hunter | Biotech Hunter