The Effects of MAP and EtCO2 on Venous Sinus Pressures

Venous sinus stenting is performed under general anesthesia. Patients are loaded with aspirin and clopidogrel before the procedure. After induction, the right femoral vein is accessed and an 8 F sheath is placed. Intravenous heparin is administered. A 0.070-0.088 guide catheter is navigated into the ipsilateral jugular vein near the jugular bulb. Pre-stenting manometry is performed in every patient. To do so, a Renegade Hi-Flo microcatheter is navigated into the superior sagittal sinus and then used to measure ipsilateral venous pressures across the site of outflow obstruction (this will be the time point where the study intervention will be performed).

End-tidal carbon dioxide concentrations will be adjusted to fall in the End-tidal carbon dioxide concentrations will be adjusted to fall in the 38-40 mmHg range

Mean arterial pressure will be adjusted to fall in the 100-110 mmHg range

Mean arterial pressure will be adjusted to fall in the 60-80 mmHg range

End-tidal carbon dioxide concentrations will be adjusted to fall in the 24-26 mmHg range