959
Participants
Start Date
May 28, 2019
Primary Completion Date
March 20, 2025
Study Completion Date
September 30, 2025
Pembrolizumab
IV infusion of Pembrolizumab 200 mg.
Placebo
IV infusion of 0.9% normal saline.
National Taiwan University Hospital ( Site 0330), Taipei
Taipei Veterans General Hospital ( Site 0331), Taipei
Chang Gung Medical Foundation. Linkou ( Site 0332), Taoyuan District
National Cheng Kung University Hospital ( Site 0334), Tainan City
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0335), Kaohsiung City
CHUV (centre hospitalier universitaire vaudois) ( Site 0712), Lausanne
Erasme Hospital ( Site 0376), Brussels
Semmelweis University ( Site 0480), Budapest
Auckland City Hospital ( Site 0246), Auckland
Hopitaux Universitaires de Geneve HUG ( Site 0711), Geneva
Royal Prince Alfred Hospital AW ( Site 0225), Camperdown
Liverpool Hospital ( Site 0226), Liverpool
Herlev Hospital ( Site 0421), Herlev
UZ Leuven ( Site 0377), Leuven
Alfred Health ( Site 0230), Melbourne
Universitaetsspital Bern ( Site 0710), Bern
St Vincents Hospital Melbourne ( Site 0227), Fitzroy
Monash Health ( Site 0233), Clayton
Complex Cancer Center Plovdiv-First Medical Oncology Department ( Site 0982), Plovdiv
Debreceni Egyetem Klinikai Kozpont Onkologiai Tanszek ( Site 0481), Debrecen
University Hospital Basel ( Site 0709), Basel
Princess Alexandra Hospital ( Site 0228), Woollongabba
Royal Adelaide Hospital ( Site 0234), Adelaide
Odense Universitets Hospital ( Site 0422), Odense C
Royal Perth Hospital ( Site 0229), Perth
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 0483), Kecskemét
SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 0482), Szeged
Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 0484), Kaposvár
Christchurch Hospital ( Site 0247), Christchurch
Universitaetsspital Zurich ( Site 0713), Zurich
Aarhus Universitets hospital ( Site 0420), Aarhus N
Kantonsspital Winterthur ( Site 0714), Winterthur
UZ Gent ( Site 0375), Ghent
Kantonsspital St. Gallen ( Site 0708), Sankt Gallen
Gleneagles Penang ( Site 0290), George Town
Penang Adventist Hospital ( Site 0289), George Town
Ramathibodi Hospital. ( Site 0352), Bangkok
National Cancer Center ( Site 0314), Goyang-si
Siriraj Hospital ( Site 0351), Bangkok
North Shore-Long Island Jewish Health System ( Site 0068), Lake Success
Hopital de la Timone ( Site 0442), Marseille
Charite - Campus Virchow Klinikum ( Site 0457), Berlin
Seoul National University Bundang Hospital ( Site 0313), Seongnam-si
Complejo Hospitalario Universitario de Santiago ( Site 0668), Santiago de Compostela
Hospital Universiti Sains Malaysia ( Site 0295), Kubang Kerian
Hospital Universitario de Donostia ( Site 0671), Donostia / San Sebastian
Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico ( Site 0550), Milan
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0540), Milan
Universitaetsklinikum Hamburg-Eppendorf ( Site 0469), Hamburg
Hospital General Universitario Gregorio Maranon ( Site 0676), Madrid
Hospital Ramon y Cajal ( Site 0673), Madrid
Hospital Universitario La Paz ( Site 0677), Madrid
Hospital Universitario Puerta de Hierro ( Site 0678), Majadahonda
Medizinische Hochschule Hannover ( Site 0458), Hanover
CHU Rangueil ( Site 0441), Toulouse
Hospital Central de Asturias ( Site 0667), Oviedo
VM Medical Park Hastanesi ( Site 0739), Mersin
CHU Bordeaux Haut-Leveque ( Site 0437), Pessac
Regional Cancer Center ( Site 0054), Fort Myers
Bezmialem Vakif University School of Medicine ( Site 0732), Istanbul
CHU Montpellier. ( Site 0443), Montpellier
Acıbadem Maslak Hastanesi ( Site 0742), Istanbul
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0730), Istanbul
Dokuz Eylul Universitesi ( Site 0740), Izmir
Vanderbilt Ingram Cancer Center ( Site 0006), Nashville
Srinagarind Hospital ( Site 0354), Khon Kaen
AOU di Bologna Policliico S. Orsola-Malpighi ( Site 0541), Bologna
James Graham Brown Cancer Center ( Site 0088), Louisville
University of Louisville ( Site 0059), Louisville
Universitaetsklinikum Duesseldorf ( Site 0461), Düsseldorf
China Medical University Hospital ( Site 0333), Taichung
Hospital Universitario Virgen del Rocio ( Site 0670), Seville
A O U Policlinico di Modena ( Site 0548), Modena
Konya Necmettin Erbakan University Medical Faculty ( Site 0736), Konya
ProMedica Flower Hospital ( Site 0090), Sylvania
Inonu University Faculty of Medicine ( Site 0729), Malatya
University of Cincinnati Medical Center ( Site 0084), Cincinnati
Miami Valley Hospital South ( Site 0093), Centerville
Indiana University Simon Cancer Center ( Site 0075), Indianapolis
Henry Ford Hospital-GI/Hepatology Research ( Site 0047), Detroit
Hospital Universitario Miguel Servet-Gastroenterology ( Site 0682), Zaragoza
Azienda Ospedaliero Universitaria Careggi ( Site 0549), Florence
Maharaj Nakorn Chiangmai Hospital ( Site 0353), Chiang Mai
Universitaetsklinikum Koeln ( Site 0463), Cologne
University of Iowa ( Site 0067), Iowa City
Azienda Ospedaliero Universitaria Pisana ( Site 0546), Pisa
Regional Clinical Onco Dispensary_ State Medical University ( Site 0782), Chernivtsi
Hopital Claude Huriez CHRU LILLE ( Site 0440), Lille
University Malaya Medical Centre ( Site 0288), Kuala Lumpur
Namik Kemal Universitesi Tip Fakultesi ( Site 0738), Tekirdağ
Krankenhaus Nord-West GmbH ( Site 0472), Frankfurt am Main
Universitaetsklinikum Frankfurt ( Site 0467), Frankfurt am Main
Regional Oncology Center of Kharkiv ( Site 0777), Kharkiv
Institut Kanser Negara - National Cancer Institute ( Site 0294), Putrajaya Wilayah Persekutuan
MI Odessa Regional Oncological Centre ( Site 0776), Odesa
HUS Hopital Hautepierre ( Site 0445), Strasbourg
CI City Clinical Hospital # 3 ( Site 0783), Zaporizhzhia
University Medical Center New Orleans ( Site 0014), New Orleans
Istituto Tumori Giovanni Paolo II ( Site 0543), Bari
Universitaetsklinikum Tuebingen ( Site 0466), Tübingen
Stephenson Cancer Center ( Site 0045), Oklahoma City
SLK-Kliniken Heilbronn GmbH ( Site 0460), Heilbronn
Baylor Scott & White Medical Center - Temple ( Site 0089), Temple
Ospedale del Mare ( Site 0545), Napoli
Klinikum rechts der Isar der Technischen Universitaet ( Site 0470), Munich
Banner MD Anderson Cancer Center ( Site 0026), Gilbert
The University of Arizona Cancer Center - North Campus ( Site 0039), Tucson
University of New Mexico ( Site 0041), Albuquerque
Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello ( Site 0547), Palermo
City of Hope Medical Center ( Site 0027), Duarte
Hopital Beaujon ( Site 0439), Clichy
Sarawak General Hospital ( Site 0293), Kuching
Hopital Paul Brousse ( Site 0447), Villejuif
Universitaetsklinikum Wuerzburg ( Site 0468), Würzburg
Virginia Mason Medical Center ( Site 0028), Seattle
Cancer Hospital Chinese Academy of Medical Sciences ( Site 0156), Beijing
Peking University People's Hospital ( Site 0191), Beijing
Beijing Cancer Hospital ( Site 0155), Beijing
Blokhin National Medical Oncology ( Site 0645), Moscow
City Clinical Hospital 1 na. NI. Pirogov ( Site 0662), Moscow
First Moscow State Medical University n.a. I.M.Sechenov ( Site 0661), Moscow
Hadassah Medical-Clinical Research Department ( Site 0920), Moscow
National Medical Research Radiological Centre ( Site 0660), Moscow
Road Hospital JSC Russian railways ( Site 0649), Saint Petersburg
Russian Scientific Center of Radiology and Surgical Technologies ( Site 0665), Saint Petersburg
City Clinical Oncology Center ( Site 0646), Saint Petersburg
Fudan University Shanghai Cancer Center ( Site 0161), Shanghai
Zhongshan Hospital Fudan University ( Site 0193), Shanghai
Renji Hospital Shanghai Jiaotong University School of Medicine ( Site 0174), Shanghai
Zhongshan Hospital affiliated to Fudan University ( Site 0153), Shanghai
Anhui Provincil Hospital South District ( Site 0181), Hefei
Zhejiang Cancer Hospital ( Site 0171), Hangzhou
Fujian Provincial Cancer Hospital ( Site 0165), Fuzhou
900 Hospital of the Joint ( Site 0197), Fuzhou
The Third Xiangya Hospital of Central South University ( Site 0167), Changsha
Hunan Provincial People Hospital ( Site 0192), Changsha
Hunan Cancer Hospital ( Site 0168), Changsha
Wuhan Union Hospital ( Site 0173), Wuhan
Hubei Cancer Hospital ( Site 0189), Wuhan
Samara Regional Clinical Oncology Center ( Site 0656), Samara
Guangdong General Hospital ( Site 0166), Guangzhou
Southern Medical University Nanfang Hospital ( Site 0172), Guangzhou
Privolzhsky District Medical Center ( Site 0655), Nizhny Novgorod
West China Hospital of Sichuan University ( Site 0162), Chengdu
Tomsk Scientific Research Institute of Oncology ( Site 0657), Tomsk
Altay Regional Oncology Dispensary ( Site 0919), Barnaul
Siberian Clinical Center of FMBA ( Site 0918), Krasnoyarsk
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0648), Krasnoyarsk
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0164), Xi’an
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0157), Ürümqi
Rambam Medical Center ( Site 0524), Haifa
Rabin Medical Center ( Site 0520), Petah Tikva
Chaim Sheba Medical Center ( Site 0523), Ramat Gan
Kindai University Hospital ( Site 0116), Sayama
Sourasky Medical Center ( Site 0522), Tel Aviv
Hiroshima University Hospital ( Site 0117), Hiroshima
Haddassah Medical Organization - Ein Kerem ( Site 0519), Jerusalem
Smilow Cancer Hospital at Yale New Haven ( Site 0042), New Haven
Massachusetts General Hospital ( Site 0062), Boston
Boston Medical Center ( Site 0025), Boston
Beth Israel Deaconess Medical Ctr. ( Site 0033), Boston
University of Massachusetts Worcester ( Site 0017), Worcester
Hospital Universitario Austral ( Site 0795), Pilar
Fundación favaloro para la Docencia e Investigación Médica ( Site 0808), Buenos Aires
Hospital Provincial del Centenario ( Site 0794), Rosario
Hospital Aleman ( Site 0806), Buenos Aires
Hospital Italiano ( Site 0793), Buenos Aires
Hospital Britanico de Buenos Aires ( Site 0792), Buenos Aires
Clinica de nefrologia urologia y enfermedades cardiovasculares ( Site 0802), Santa Fe
University Hospital Antwerp (UZA) ( Site 0374), Edegem
CIONC - Centro Integrado de Oncologia de Curitiba ( Site 0813), Curitiba
Hospital de Cancer de Pernambuco ( Site 0815), Recife
Hospital de Clinicas de Porto Alegre ( Site 0824), Porto Alegre
Clinica de Oncologia Reichow ( Site 0818), Blumenau
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0820), Itajaí
Hospital Paulistano ( Site 0829), São Paulo
Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0828), São Paulo
Instituto COI de Pesquisa Educacao e Gestao ( Site 0825), Rio de Janeiro
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0826), São Paulo
A.C. Camargo Cancer Center ( Site 0827), São Paulo
Casa de Saude Santa Marcelina ( Site 0821), São Paulo
Nova Scotia Health Authority QEII-HSC ( Site 0208), Halifax
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0211), Montreal
McGill University Health Centre ( Site 0207), Montreal
Staedtisches Klinikum Dresden ( Site 0471), Dresden
Universitatsklinikum Carl Gustav Carus ( Site 0459), Dresden
Prince of Wales Hospital ( Site 0268), Hong Kong
Pamela Youde Nethersole Eastern Hospital ( Site 0271), Hong Kong
Queen Mary Hospital ( Site 0267), Hong Kong
Tuen Mun Hospital ( Site 0272), Tuenmen
Azienda Ospedaliera Ordine Mauriziano di Torino ( Site 0542), Turin
St Vincent's University Hospital ( Site 0498), Dublin
Tallaght University Hospital ( Site 0499), Dublin
Ehime University Hospital ( Site 0123), Tōon
Kurume University Hospital ( Site 0119), Kurume
Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital ( Site 0102), Sapporo
Kanazawa University Hospital ( Site 0111), Kanazawa
Kagawa University Hospital ( Site 0121), Kita-gun
Kagawa Prefectural Central Hospital ( Site 0122), Takamatsu
Toranomon Hospital Kajigaya ( Site 0109), Kawasaki
Yokohama City University Medical Center ( Site 0110), Yokohama
Saitama Medical University Hospital ( Site 0104), Iruma-gun
Kyorin University Hospital ( Site 0106), Mitaka
Musashino Red Cross Hospital ( Site 0107), Musashino
Chiba University Hospital ( Site 0103), Chiba
National Hospital Organization Kyushu Medical Center ( Site 0118), Fukuoka
University Hospital, Kyoto Prefectural University of Medicine ( Site 0112), Kyoto
Japanese Red Cross Osaka Hospital ( Site 0113), Osaka
Osaka Metropolitan University Hospital. ( Site 0114), Osaka
Saga-Ken Medical Centre Koseikan ( Site 0120), Saga
Toranomon Hospital ( Site 0108), Tokyo
The University of Tokyo Hospital ( Site 0105), Tokyo
Wakayama Medical University Hospital ( Site 0115), Wakayama
Oslo Universitetssykehus HF. Ulleval ( Site 0433), Oslo
Izerskie Centrum Pulmonologii i Chemioterapii IZER-MED Spolka z o.o. ( Site 0607), Szklarska Poręba
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie ( Site 0620), Lublin
MTZ Clinical Research Sp. z o. o. ( Site 0608), Warsaw
Copernicus PL Sp. z o.o. ( Site 0603), Gdansk
ID Clinic ( Site 0619), Mysłowice
SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 0606), Olsztyn
Szpital Wojewodzki im. Mikolaja Kopernika ( Site 0604), Koszalin
Seoul National University Hospital ( Site 0312), Seoul
Severance Hospital Yonsei University Health System ( Site 0309), Seoul
Asan Medical Center ( Site 0310), Seoul
Samsung Medical Center ( Site 0311), Seoul
The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0315), Seoul
Hospital Universitari Parc Tauli ( Site 0681), Sabadell
Hospital Universitari Vall d Hebron ( Site 0674), Barcelona
Skane University Hospital ( Site 0692), Malmo
Karolinska Universitetssjukhuset, Huddinge ( Site 0689), Stockholm
Norrlands Universitetssjukhus ( Site 0687), Umeå
Sahlgrenska Universitetssjukhuset ( Site 0691), Gothenburg
Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 0733), Adana
Gulhane Egitim ve Arastirma Hastanesi ( Site 0741), Ankara
Ankara Sehir Hastanesi ( Site 0731), Ankara
Adnan Menderes University Medical Faculty ( Site 0737), Aydin
National Cancer Institute of the MoH of Ukraine ( Site 0779), Kyiv
Shalimov s NI of Surgery and Transplantation ( Site 0781), Kyiv
Universal Clinic Oberig-Oncology Center ( Site 0786), Kyiv
Medical Center Dobrobut Clinic ( Site 0785), Kyiv
Cambridge University Hospitals NHS Trust ( Site 0755), Cambridge
Weston Park Hospital ( Site 0753), Sheffield
The Beatson West of Scotland Cancer Centre ( Site 0750), Glasgow
Kings College Hospital NHS Foundation Trust ( Site 0758), London
Belfast City Hospital ( Site 0752), Belfast
The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0757), Birkenhead
University Hospital Coventry and Warwickshire NHS Trust ( Site 0754), Coventry
Leeds Teaching Hospitals NHS Trust ( Site 0751), Leeds
Nottingham University Hospitals NHS Trust ( Site 0756), Nottingham
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INDUSTRY